Ritalinic acid

Ritalinic acid
Clinical data
ATC code	None;
Legal status
Legal status	US: Unscheduled and Uncontrolled;
Identifiers
	IUPAC name Phenyl(piperidin-2-yl)acetic acid;
CAS Number	19395-41-6 ;
PubChem CID	86863;
ChemSpider	78360 ;
UNII	GT4165RS9H;
CompTox Dashboard (EPA)	DTXSID20864888 ;
ECHA InfoCard	100.039.094
Chemical and physical data
Formula	C13H17NO2
Molar mass	219.284 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O;
	InChI InChI=InChI=1S/C13H17NO2/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16) ; Key:INGSNVSERUZOAK-UHFFFAOYSA-N ;
	(verify)

Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the psychostimulant drugs methylphenidate, dexmethylphenidate and ethylphenidate.^[1]^[2] When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester group yielding ritalinic acid.^[1] The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1).^[3]