SB-205384

SB-205384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.

Legal status

• US: Investigational New Drug

CAS Number

• 160296-13-9 ^Y

PubChem CID

• 197690

ChemSpider

• 171116 ^N

Quick facts Legal status, Identifiers ...

SB-205384

Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name But-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyridine-3-carboxylate
CAS Number	160296-13-9 Y
PubChem CID	197690
ChemSpider	171116 N
CompTox Dashboard (EPA)	DTXSID00936259
Chemical and physical data
Formula	C17H18N2O3S
Molar mass	330.40 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
InChI InChI=1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19) N Key:JDTZAGLGBRRCJT-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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SB-205384 is a GABA_A positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes.^[1][2] It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile,^[3] with tests showing that it alters the firing of some populations of neurons while leaving others unaffected.^[4] Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes.^[5][6]