SB-649915

SB-649915 is a serotonin reuptake inhibitor and serotonin 5-HT_1A and 5-HT_1B receptor antagonist which is being investigated for its antidepressant effects.^[1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well.^[1] This can be attributed to blockade of 5-HT_1A and 5-HT_1B autoreceptors which inhibit serotonin release.^[1]

Other namesSB649915; SB-649,915

Drug classSerotonin reuptake inhibitor; Serotonin 5-HT_1A receptor antagonist; Serotonin 5-HT_1B receptor antagonist

ATC code

• None

Legal status

• In general: uncontrolled

Quick facts Clinical data, Other names ...

SB-649915

Clinical data
Other names	SB649915; SB-649,915
Drug class	Serotonin reuptake inhibitor; Serotonin 5-HT1A receptor antagonist; Serotonin 5-HT1B receptor antagonist
ATC code	None
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 6-[[1-[2-(2-methylquinolin-5-yl)oxyethyl]piperidin-4-yl]methyl]-4H-1,4-benzoxazin-3-one
CAS Number	420785-70-2 N
PubChem CID	10296414
IUPHAR/BPS	76
ChemSpider	8471882 N
UNII	HD3UV2MFJ8
ChEMBL	ChEMBL183460 N
Chemical and physical data
Formula	C26H29N3O3
Molar mass	431.536 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC5=C(C=C4)OCC(=O)N5
InChI InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30) N Key:PJSUYRBCBFPCQW-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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