Sodium-dependent neutral amino acid transporter B(0)AT2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.[5]

AliasesSLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
End84,913,629 bp[1]
Quick facts SLC6A15, Identifiers ...
SLC6A15
Identifiers
AliasesSLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDsOMIM: 607971; MGI: 2143484; HomoloGene: 18163; GeneCards: SLC6A15; OMA:SLC6A15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146335
NM_018057
NM_182767

NM_001252330
NM_175328
NM_001358821

RefSeq (protein)

NP_001139807
NP_060527
NP_877499

NP_001239259
NP_780537
NP_001345750

Location (UCSC)Chr 12: 84.86 – 84.91 MbChr 10: 103.2 – 103.26 Mb
PubMed search[3][4]
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Function

SLC6A15 shows structural characteristics of an Na+ and Cl-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[6]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[7]

References

Further reading

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