SRT-1460

SRT-1460
Identifiers
	IUPAC name 3,4,5-trimethoxy-N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide;
CAS Number	925432-73-1;
PubChem CID	24180124;
ChemSpider	23315250;
UNII	FN6D3F3HTG;
CompTox Dashboard (EPA)	DTXSID40636044 ;
Chemical and physical data
Formula	C26H29N5O4S
Molar mass	507.61 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1cc(cc(c1OC)OC)C(=O)Nc2ccccc2c3cn4c(csc4n3)CN5CCNCC5;

SRT-1460 is a drug in development by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in animal studies to the known SIRT1 activator resveratrol, but is closer in potency to SRT-1720. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function.^[1] However, the claim that SRT1460 is a SIRT1 activator has been questioned^[2] and further defended.^[3]

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Identifiers

IUPAC name 3,4,5-trimethoxy-N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide
CAS Number	925432-73-1
PubChem CID	24180124
ChemSpider	23315250
UNII	FN6D3F3HTG
CompTox Dashboard (EPA)	DTXSID40636044
Chemical and physical data
Formula	C₂₆H₂₉N₅O₄S
Molar mass	507.61 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COc1cc(cc(c1OC)OC)C(=O)Nc2ccccc2c3cn4c(csc4n3)CN5CCNCC5