The facade has two orders of columns, set on high plinths. In this, it recalls the facade of a church, four blocks north and also on Via Terramuzzo: Santa Maria della Pietà, also designed by the same architect Amato. However the uniformity of stone, give this facade a more muted neoclassical style.
Above the main portal is a round 17th-century bas-relief depicting the Holy Family with the Holy Spirit, sculpted by Cristoforo Milanti. Inside, the first chapel or altar on the right, has an altarpiece depicting the Trasverberation of the Heart of St Teresa by Guglielmo Borremans. The second chapel on the left, dedicated to the Madonna of the Carmine, has a painting depicting St John of the Cross by Sebastiano Conca. The chapel of the Holy Family has an altarpiece by Giovanni Odasi. The Altar of the Crucifix has a sculpture by Ignazio Marabitti.
The presbytery is decorated with four columns of grey Billiemi marble. The main altar was originally made with semi-precious stones including agates, amethyst, and lapis-lazuli. The candelabra are gilded wood. The main altarpiece depicts the Proclamation by the Council of Ephesus in 431 of the divinity of the Madonna. Above this altarpiece is a representation of the Holy Spirit (dove) in 19 gilded rays, symbolizing the 7 graces and 12 fruits of the Holy Spirit. The altar is flanked by two stucco statues by Giacomo Serpotta and his son, depicting: St Anne (left) and St Teresa (on right with book). In the register above the statues are four paintings related to the Eucharist, including The Widow of Zareptha brings Elijah bread; the Harvest of grapes; the Blessed Ruth gathers wheat in the fields of Boaz; and the Profanation of the sacrifice.
Presbytery with main altar, flanked by Saints Anne and Teresa
Altar of Santa Teresa with Ecstasy of St Teresa by Borremans
Altar of the Madonna of the Carmine with the canvas Virgin grants the scapular to St Simon Stock by Conca
Altar of the Crucifixion with marble sculptures by Marabitti