Sodium tetradecyl sulfate
Anionic surfactant in common use
From Wikipedia, the free encyclopedia
Sodium tetradecyl sulfate (STS), is a common anionic surfactant. The compound consists of the sodium salt of the micelle-forming sulfate ester of 7-Ethyl-2-methyl-4-undecanol[1]. It is a white, water-soluble solid of low toxicity with many practical uses.[2]
administrationIntravenous injection
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| Other names | 7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt |
| AHFS/Drugs.com | Consumer Drug Information |
| Routes of administration | Intravenous injection |
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| ECHA InfoCard | 100.004.892 |
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| Formula | C14H29NaO4S |
| Molar mass | 316.43 g·mol−1 |
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Applications
Medicine
It the active component of the sclerosant drugs Sotradecol and Fibrovein. It is commonly used in the treatment of varicose and spider veins of the leg, during the procedure of sclerotherapy.[3] Being a detergent, its action is on the lipid molecules in the cells of the vein wall, causing inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein. It is used in concentrations ranging from 0.1% to 3% for this purpose.
It is occasionally used for the treatment of stabilisation of joints that regularly dislocate, particularly in patients with Ehlers-Danlos syndrome.[4] In the UK, Ireland, Italy, Australia, New Zealand and South Africa, it is sold under the trade-name Fibro-Vein in concentrations of 0.2%, 0.5%, 1.0%, and 3%.[5]
Synthesis
Tetradecyl alcohol is treated with sulfur trioxide followed by neutralization of the resulting pyrosulfuric acid with sodium hydroxide.[2]
