GIGYF2

GIGYF2
Identifiers
Aliases	GIGYF2, GYF2, PARK11, PERQ2, PERQ3, TNRC15, GRB10 interacting GYF protein 2
External IDs	OMIM: 612003; MGI: 2138584; GeneCards: GIGYF2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,860,605 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,378,518 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; testicle; ; right testis; ; left testis; ; corpus callosum; ; islet of Langerhans; ; bone marrow cell; ; ventricular zone;
	Top expressed in
	zygote; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; yolk sac; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; primary visual cortex; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; proline-rich region binding; RNA binding; cadherin binding;
Cellular component	membrane; cytoplasm; endosome; endoplasmic reticulum; Golgi apparatus; cytosol; cytoplasmic stress granule; integral component of membrane; vesicle; perikaryon; proximal dendrite; protein-containing complex;
Biological process	adult locomotory behavior; homeostasis of number of cells within a tissue; negative regulation of translation; spinal cord motor neuron differentiation; post-embryonic development; mitotic G1 DNA damage checkpoint signaling; feeding behavior; musculoskeletal movement; multicellular organism growth; neuromuscular process controlling balance; posttranscriptional gene silencing; insulin-like growth factor receptor signaling pathway; mRNA destabilization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26058
	227331
	ENSG00000204120
	ENSMUSG00000048000
	Q6Y7W6
	Q6Y7W8
	NM_001103146; NM_001103147; NM_001103148; NM_015575
	NM_001110212; NM_146112
	NP_001096616; NP_001096617; NP_001096618; NP_056390
	NP_001103682; NP_666224
	Wikidata
View/Edit Human	View/Edit Mouse

GRB10-interacting GYF protein 2 is a protein that in humans is encoded by the GIGYF2 gene (previously TNRC15).^[5]^[6]^[7]^[8]^[9] The GIGYF2 protein is a core part of the 4EHP-GYF2 complex, a complex made out of multiple proteins which inhibits the initiation of RNA to protein translation.^[10]