Talk:Animal testing/Archive 11

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In vivo?

Animal testing is not known as "in vivo". In vivo means the use of an entire (not necessarily fully intact) organism, which could be human or non-human.Desoto10 (talk) 07:00, 10 January 2010 (UTC)

In vivo can apply to humans or animals, thus is a synonym of both. Mokele (talk) 17:44, 10 January 2010 (UTC)
One can argue it either way, but I think it's OK to continue to say "in vivo" here. The term actually means alive, and includes both human and non-human. In vivo, to which it links, says clearly that it includes both animal testing and clinical trials. It's true, therefore, that there are kinds of in vivo testing that are not animal testing, but the animal testing that is of interest to this page is in vivo testing (ie, as distinguished from animal cells in tissue culture). As I said, this can be argued either way, but I think there is no harm in leaving it as is. --Tryptofish (talk) 19:05, 10 January 2010 (UTC)

asking wikipedia a question about animal testing at wikipedia the free encyclopedia

what is the year of edition for the article on anamal testing at wikipedia the free encyclopedia and also what is the library for animal testing andwho is the author and how many pages are there and what is the title of the article. Forany farther notice or help on answering the question for me. PLEASE refer to my email account at elyssd11@gmail.com thank u for the help wikipedia.--67.163.177.247 (talk) 23:43, 11 March 2010 (UTC)Elyssa Deaner

Elyssa, some of those concepts do not exactly apply here. Obviously, the article is Animal testing. The correct place to ask how that sort of thing works is at Wikipedia:Help desk. --Tryptofish (talk) 23:49, 11 March 2010 (UTC)

Prominent cases?

The lead sentence [All knowledge of muscle physiology is based on work done using frog muscles] seems bizarre and is not supported by the cited ref which claims that more emphasis has been placed on human muscles. I appreciate you going through this, Mokele, but I'd suggest that his be changed to "Much" or even "Most" instead of all. Bob98133 (talk) 12:58, 24 March 2010 (UTC)

The cited ref places emphasis on human muscles for teaching purposes, but the concepts discussed were all discovered in frog muscles. The only reason anyone even uses mammals is that you can get pure fiber-type muscles (mouse EDL for fast and cat soleus for slow) and can genetically modify mice to express disease states. Even then, it's still all based on work done in frogs. Still, primary sources would be better, so I'll re-do it. Mokele (talk) 14:47, 24 March 2010 (UTC)
Thanks. My main problem is with the word "all" since it's near impossible to prove, like biggest, best, etc. I'm sure that knowledge about muscle physiology must have been acquired using other species as well, even if these studies are not as frequently cited. Bob98133 (talk) 13:22, 25 March 2010 (UTC)

Edit request from Boothie1, 23 April 2010

Although no accepted in vitro alternatives exist, a modified form of the Draize test called the low volume eye test may reduce suffering and provide more realistic results, but it has not yet replaced the original test.[1]

This needs editing to.

The following was copied from: http://www.drhadwentrust.org/news/rabbit-eye-test-replacement#fn9909468184ab801ac0cd77


Acceptance by the Organisation for Economic Cooperation and Development (OECD) means that guidance is finally in place on how to conduct the tests without using live rabbits 2. Two test-tube methods for assessing eye irritation have been accepted by the OECD, the BCOP (Bovine Corneal Opacity and Permeability) test and the ICE (Isolated Chicken Eye) test, both for identifying ocular corrosives and severe irritants.

Whilst the Draize test will continue to be conducted for substances that are not severe eye-irritants, the OECD’s decision does mean that many thousands of rabbits will be spared distressing and painful tests that have been scientifically criticised for many decades for poor reproducibility and species differences between rabbits and humans3. Some 4,500 rabbits are used in eye irritancy tests in the European Union each year4. Global use is likely to be considerably higher.

It has taken at least thirty years for alternative tests to be approved, with research starting in the 1980s, scientific approval by the European Centre for the Validation of Alternative Methods (ECVAM) coming in 2007 and now OECD acceptance in 2009 meaning that the new tests can be used globally.


Sources

1 Developed in 1944, the Draize rabbit eye irritation test has been the standard method for evaluating the ocular irritation/corrosion potential of a substance for regulatory purposes. Adult albino rabbits are most commonly used for eye irritancy tests because they have eyes with a large surface area. At least three animals are used per test substance. The test involves applying the substance directly into one eye (the other eye acting as a control) and observing effects for up to 21 days. Effects can include swelling, soreness and weeping eyes.

2 The OECD adopted the new methods on 7 September 2009

3 For example Weil & Scala (1971) Toxicol.Appl.Pharmacol. 17,276-360; Freeberg et al. (1986) J. Toxicol.Cut.Ocular Toxicol. 5, 115-123; Koch et al. (1989) J.Toxicol Cut.Ocular Toxicol. 8, 17-22.

4 Latest statistics available from the European Commission are for 2005

5 The Dr Hadwen Trust funded Dr Colin Muir, a research fellow at Leicester Polytechnic. Dr Muir developed the ‘opacitometer’ which shines a light beam through the isolated cornea enabling an objective measurement of changes in its opacity. His publications between 1984 and 1987 are acknowledged as providing the essential groundwork and inspiration for the BCOP test.

Boothie1 (talk) 18:34, 23 April 2010 (UTC)

The BUAV aso welcomed this. Thank you, I've updated the article. Tim Vickers (talk) 19:57, 23 April 2010 (UTC)

Merge proposal

Another editor, not me, added the tags about merging the animal sources page into here. I'm not sure what I think about it, but I agree that it is worth examining. On the minus side, the material is lengthy enough that it may make sense to keep two separate pages. On the other hand, the other page does bother me a little bit, as a potential POV fork that implies that there is inherently an ethical problem with such sources. Other thoughts? --Tryptofish (talk) 21:59, 31 May 2010 (UTC)

I could go either way on the merge, but the page in question has some serious POV issues, simply due to the sheer quantity of text about an animal source that probably doesn't even exist and is a tiny minority of animals used if it does. Mokele (talk) 23:09, 31 May 2010 (UTC)
I'm not really opposed to a merge, but I think it might be better if the animal sources article were improved and linked to from this article. Bob98133 (talk) 00:28, 1 June 2010 (UTC)

PETA or PeTA?

SV - I see you made some changes from PETA to PeTA. I think the former is correct. The acronym for the org is PETA. The PeTA is really a stylized version of the acronym that they use as a logo. Except as a logo, they consistently use the all uppercase version on their webiste, in press releases, etc. Bob98133 (talk) 20:15, 5 July 2010 (UTC)

Likewise at PETA. --Tryptofish (talk) 20:18, 5 July 2010 (UTC)
I don't mind either way. SlimVirgin talk|contribs 20:25, 6 July 2010 (UTC)
If SV does not feel strongly either way, then I would tend to agree with Bob's argument, applied both to this page and to PETA. --Tryptofish (talk) 22:06, 6 July 2010 (UTC)

Definitions

Changes to page

Cases

Xenotransplantation request

Edit request: spelling error

REM-deprivation method

Opening image

POV issues

Animals in Space Section?

Split ethics section to own article

File:Frog vivisection.jpg Nominated for Deletion

Expand tag

Condense the prominent cases section

"Wanton" taking of animal life?

Summary of an article by Robert J. White

Opinion piece by Hartung (2009)

First line and definition

Requested move 1 January 2016

More Images

Critiquing an Article

Biased article

Tone

Video

Pain and suffering

Adding "Cruelty to animals" category in Animal Testing article

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