Talk:Cereblon

It looks like a lot of the material in this article may be outdated, or at least that some of the statements (and references) need to be updated to more accurately reflect the current understanding of Cereblon, analogs and related factors and pathways associated with thalidomide, as well as the teratogenic effects implied or associated here. Jdevola (talk) 13:06, 15 October 2019 (UTC)

This edit request by an editor with a conflict of interest was declined.

I am Joseph J. Higgins, one of the authors of publications cited in this article. Because this represents a potential conflict of interest, I am requesting review by independent editors rather than making the edit myself.

Suggested addition to the Intellectual Disability section:

"The first reported association between CRBN and autosomal recessive nonsyndromic intellectual disability was published in 2004 following identification of a homozygous nonsense mutation in a large family. Subsequent work further characterized biological consequences of the CRBN p.R419X mutation, including dysregulation of large-conductance calcium-activated potassium channel expression. Later studies using cereblon-deficient mouse models demonstrated deficits in learning and memory and rescue of these deficits through modulation of the AMPK–mTORC1 translational pathway, providing additional evidence for a role of CRBN in learning, memory, and intellectual disability."

References:

Higgins JJ, Pucilowska J, Lombardi RQ, Rooney JP. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. Neurology. 2004;63(10):1927–1931. PMID: 15557513.

Higgins JJ, Hao J, Kosofsky BE, Rajadhyaksha AM. Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics. 2008;9(3):219–223. PMID: 18414909.

Rajadhyaksha AM, Ra S, Byrne M, et al., Higgins JJ. Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res. 2012;226:428–434. PMID: 21995942.

Bavley CC, Rice RC, Fischer DK, et al., Higgins JJ, D'Adamio L, Rajadhyaksha AM. Rescue of learning and memory deficits in the human non-syndromic intellectual disability cereblon knockout mouse model by targeting the AMPK-mTORC1 translational pathway. J Neurosci. 2018;38:2780–2795. PMID: 29459374.

Thank you for considering this suggested clarification.

HigginsJJPedNeuro (talk) 17:10, 27 July 2026 (UTC)

N Declined Per WP:NOTPROMO. Regards,  Spintendo  23:24, 11 August 2026 (UTC)