Heptaprenyl diphosphate synthase
Class of enzymes
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In enzymology, a heptaprenyl diphosphate synthase (EC 2.5.1.30) is an enzyme that catalyzes the chemical reaction
- (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate 4 diphosphate + all-trans-heptaprenyl diphosphate
| heptaprenyl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.30 | ||||||||
| CAS no. | 74506-59-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (2E,6E)-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units). Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.
Structural studies
References
- Takahashi I, Ogura K, Seto S (1980). "Heptaprenyl pyrophosphate synthetase from Bacillus subtilis". J. Biol. Chem. 255 (10): 4539â43. doi:10.1016/S0021-9258(19)85526-6. PMID 6768722.
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