Transformer (gene)

Protein family From Wikipedia, the free encyclopedia

Transformer (tra) is a family of genes which regulate sex determination in insects such as flies.[1][2] Among its effects, it (P11596) regulates differences between males and females in Drosophila fruit flies.[3]

Alternative splicing of the Drosophila Transformer gene product.
Quick facts Female-specific protein transformer, Identifiers ...
Female-specific protein transformer
Identifiers
SymbolTra
PfamPF06495
InterProIPR010519
Available protein structures:
PDB  IPR010519 PF06495 (ECOD; PDBsum)  
AlphaFold
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Quick facts Identifiers, Organism ...
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The tra-2 gene (P19018) is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex.[4][5]

References

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