Triethylenemelamine

Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.^[1]

ATC code

• None

CAS Number

• 51-18-3 ^Y

PubChem CID

• 5799

ChemSpider

• 5594 ^N

Quick facts Clinical data, ATC code ...

Triethylenemelamine

Clinical data
ATC code	None
Identifiers
IUPAC name 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
CAS Number	51-18-3 Y
PubChem CID	5799
ChemSpider	5594 N
UNII	F7IY6HZG9D
KEGG	C07642 N
ChEMBL	ChEMBL502384 N
CompTox Dashboard (EPA)	DTXSID3026225
ECHA InfoCard	100.000.076
Chemical and physical data
Formula	C9H12N6
Molar mass	204.237 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN1c2nc(nc(n2)N3CC3)N4CC4
InChI InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2 N Key:IUCJMVBFZDHPDX-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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It is a mutagenic chemical because it is an alkylating antineoplastic agent, a trifunctional alkylating agent that has three reactive groups that enable it to bind covalently to DNA at three distinct sites. As a result, TEM can cause chromatid aberrations in cell models.^[2] It was one of the first compounds used for chemical mutagenesis in laboratory mice, with the impact on mutagenesis measured by the specific-locus test by Bruce Cattanach.^[3]