Tyrosine phenol-lyase
From Wikipedia, the free encyclopedia
The enzyme tyrosine phenol-lyase (EC 4.1.99.2) catalyzes the chemical reaction
- L-tyrosine + H2O phenol + pyruvate + NH3
This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is L-tyrosine phenol-lyase (deaminating; pyruvate-forming). Other names in common use include beta-tyrosinase, and L-tyrosine phenol-lyase (deaminating). This enzyme participates in tyrosine metabolism and nitrogen metabolism. It employs one cofactor, pyridoxal phosphate.
Structural studies
References
- Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. I. Purification, crystallization, and properties". J. Biol. Chem. 245 (7): 1767–72. doi:10.1016/S0021-9258(19)77158-0. PMID 4908868.
- Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. II. Cofactor requirements". J. Biol. Chem. 245 (7): 1773–7. doi:10.1016/S0021-9258(19)77159-2. PMID 4908869.
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