Spiradoline

Selective κ-opioid agonist drug From Wikipedia, the free encyclopedia

Spiradoline (U-62066) is a drug which acts as a highly selective κ-opioid agonist.[1] It has analgesic,[2] diuretic,[3] and antitussive effects,[4] and produces subjective effects in animals similar to those of ketazocine and alazocine.[5] The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically.[6]

Routes of
administrationN/A
ATC code
  • none
CAS Number
PubChem CID
Quick facts Clinical data, Routes ofadministration ...
Spiradoline
Clinical data
Routes of
administration		N/A
ATC code
  • none
Identifiers
  • 2-(3,4-Dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl] acetamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H30Cl2N2O2
Molar mass425.39 g·mol−1
3D model (JSmol)
  • CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
  • InChI=1S/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1 ☒N
  • Key:NYKCGQQJNVPOLU-ONTIZHBOSA-N ☒N
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