U12 minor spliceosomal RNA
RNA family
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U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1]
| U12 minor spliceosomal RNA | |
|---|---|
Predicted secondary structure and sequence conservation of U12 | |
| Identifiers | |
| Symbol | U12 |
| Rfam | RF00007 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain | Eukaryota |
| GO | GO:0000371 GO:0045131 GO:0005693 |
| SO | SO:0000399 |
| PDB structures | PDBe |
Structure
The predicted secondary structure of U12 RNA is published,.[2] However, the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.[3] The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.
