UBA5

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesUBA5, THIFP1, UBE1DC1, ubiquitin like modifier activating enzyme 5, SCAR24, EIEE44, DEE44

External IDsOMIM: 610552; MGI: 1913913; HomoloGene: 11738; GeneCards: UBA5; OMA:UBA5 - orthologs

Chr.Chromosome 3 (human)^[1]

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UBA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GUC, 3H8V, 5HKH
Identifiers
Aliases	UBA5, THIFP1, UBE1DC1, ubiquitin like modifier activating enzyme 5, SCAR24, EIEE44, DEE44
External IDs	OMIM: 610552; MGI: 1913913; HomoloGene: 11738; GeneCards: UBA5; OMA:UBA5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 132,654,446 bp[1] End 132,679,794 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 103,923,798 bp[2] End 103,940,333 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex parotid gland anterior pituitary Achilles tendon minor salivary glands secondary oocyte Top expressed in lacrimal gland Ileal epithelium parotid gland seminal vesicula fossa islet of Langerhans supraoptic nucleus facial motor nucleus substantia nigra median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ubiquitin-like modifier activating enzyme activity ATP binding metal ion binding UFM1 activating enzyme activity Cellular component cytoplasm intracellular membrane-bounded organelle nucleus cytosol Golgi apparatus Biological process regulation of intracellular estrogen receptor signaling pathway protein K69-linked ufmylation response to endoplasmic reticulum stress protein ufmylation neuromuscular process protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79876 66663 Ensembl ENSG00000081307 ENSMUSG00000032557 UniProt Q9GZZ9 Q8VE47 RefSeq (mRNA) NM_024818 NM_198329 NM_001320210 NM_001321238 NM_001321239 NM_025692 RefSeq (protein) NP_001307139 NP_001308167 NP_001308168 NP_079094 NP_938143 NP_079968 Location (UCSC) Chr 3: 132.65 – 132.68 Mb Chr 9: 103.92 – 103.94 Mb PubMed search [3] [4]
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This gene encodes a member of the E1-like activating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]