UBA6

UBA6
Identifiers
Aliases	UBA6, E1-L2, MOP-4, UBE1L2, ubiquitin like modifier activating enzyme 6
External IDs	OMIM: 611361; MGI: 1913894; GeneCards: UBA6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,701,155 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,320,662 bp
RNA expression pattern
	Top expressed in
	oocyte; ; epithelium of nasopharynx; ; Achilles tendon; ; gingival epithelium; ; germinal epithelium; ; mucosa of paranasal sinus; ; endothelial cell; ; ventricular zone; ; corpus callosum; ; oral cavity;
	Top expressed in
	otic vesicle; ; hand; ; spermatogonium; ; trigeminal ganglion; ; primitive streak; ; superior cervical ganglion; ; otolith organ; ; maxillary prominence; ; utricle; ; pineal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	FAT10 activating enzyme activity; nucleotide binding; ligase activity; protein binding; ATP binding; ubiquitin-like modifier activating enzyme activity; ubiquitin activating enzyme activity;
Cellular component	cytosol; cytoplasm;
Biological process	dendritic spine development; amygdala development; learning; hippocampus development; ubiquitin-dependent protein catabolic process; locomotory behavior; protein ubiquitination; cellular response to DNA damage stimulus; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55236
	231380
	ENSG00000033178
	ENSMUSG00000035898
	A0AVT1; H0Y9U5
	Q8C7R4
	NM_018227
	NM_172712
	NP_060697
	NP_766300
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 6 is an enzyme that in humans is encoded by the UBA6 gene (previously UBE1L2).^[5]^[6] This enzyme functions to activate ubiquitin through adenylation.^[7]