Ubiquitin carboxyl-terminal hydrolase L5

UCHL5
Identifiers
Aliases	UCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
External IDs	OMIM: 610667; MGI: 1914848; HomoloGene: 9326; GeneCards: UCHL5; OMA:UCHL5 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	193,060,080 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,683,204 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; islet of Langerhans; ; body of pancreas; ; prefrontal cortex; ; muscle of thigh; ; rectum; ; monocyte; ; gonad; ; gastrocnemius muscle; ; epithelium of colon;
	Top expressed in
	morula; ; embryo; ; blastocyst; ; yolk sac; ; parotid gland; ; otic placode; ; tail of embryo; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; thiol-dependent deubiquitinase; peptidase activity; protein binding; endopeptidase inhibitor activity; hydrolase activity; RNA binding; proteasome binding;
Cellular component	cytoplasm; intracellular anatomical structure; proteasome complex; nucleus; cytosolic proteasome complex; nucleoplasm; mitochondrion; cytosol; Ino80 complex;
Biological process	regulation of proteasomal protein catabolic process; DNA recombination; regulation of transcription, DNA-templated; lateral ventricle development; ubiquitin-dependent protein catabolic process; transcription, DNA-templated; proteolysis; cellular response to DNA damage stimulus; forebrain morphogenesis; DNA repair; midbrain development; negative regulation of endopeptidase activity; protein deubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51377
	56207
	ENSG00000116750
	ENSMUSG00000018189
	Q9Y5K5; Q5LJB0
	Q9WUP7
NM_001199261; NM_001199262; NM_001199263; NM_015984; NM_001350840;
	NM_001350841; NM_001350842; NM_001350843; NM_001350844; NM_001350845; NM_001350846; NM_001350847; NM_001350848; NM_001350849; NM_001350850; NM_001350851; NM_001350852
	NM_001159866; NM_019562
NP_001186190; NP_001186191; NP_001186192; NP_057068; NP_001337769;
	NP_001337770; NP_001337771; NP_001337772; NP_001337773; NP_001337774; NP_001337775; NP_001337776; NP_001337777; NP_001337778; NP_001337779; NP_001337780; NP_001337781
	NP_001153338; NP_062508
	Wikidata
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