United States drug overdose death rates and totals over time
US public health issue
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The United States Centers for Disease Control and Prevention (CDC) provides data on drug overdose death rates and totals in the United States.




Around 70,000 people died in the 12-month period ending December 31, 2025, at a rate of 192 deaths per day. That is 20.5 deaths per 100,000 US residents, using the population at the midpoint of that period (341,784,857 on July 1, 2025).[4][5][6]
The peak was around 110,900 in 2022. The U.S. drug overdose death rate has gone from 2.5 per 100,000 people in 1968 to the peak rate of 33.2 per 100,000 in 2022.[7][6]
From 1968 to 2020, approximately 1,106,900 U.S. residents died from drug overdoses, with the majority – around 932,400 – of those deaths occurring between 1999 and 2020.
Of the roughly 110,700 drug overdose deaths in 2021 (the total at the time that these numbers were calculated), opioids were involved in about 80,400, or nearly 73%, of cases, with synthetic opioids other than methadone (primarily fentanyl) involved in around 70,600, or nearly 64%, of all deaths.[6][4][7][1][2]
The CDC's "predicted value" is used for numbers for recent years in the above intro. CDC: "Predicted provisional counts represent estimates of the number of deaths adjusted for incomplete reporting (see Technical Notes)." And the above yearly numbers are updated regularly here as they change.[6][4]
1968–2022

The numbers at the CDC source for the table below are continually updated. So the numbers in the table below may be slightly different.[7][9] 2021 was a turning point in US history with over 100,000 deaths.[10]
- Rates below are per 100,000.
- Population is for July 1 residents.
- Rate (by itself) is age adjusted.
- Total (at bottom) is 1,106,859 total deaths for 1968–2020.
| Year | Deaths | Population | Crude rate | Rate |
|---|---|---|---|---|
| 1968 | 5,033 | 199,533,564 | 2.5 | 2.8 |
| 1969 | 6,006 | 201,568,206 | 3.0 | 3.3 |
| 1970 | 7,101 | 203,458,035 | 3.5 | 3.8 |
| 1971 | 6,771 | 206,782,970 | 3.3 | 3.5 |
| 1972 | 6,622 | 209,237,411 | 3.2 | 3.4 |
| 1973 | 6,413 | 211,361,965 | 3.0 | 3.2 |
| 1974 | 6,449 | 213,436,958 | 3.0 | 3.2 |
| 1975 | 7,145 | 215,457,198 | 3.3 | 3.4 |
| 1976 | 6,765 | 217,615,788 | 3.1 | 3.2 |
| 1977 | 6,130 | 219,808,632 | 2.8 | 2.9 |
| 1978 | 5,506 | 222,102,279 | 2.5 | 2.6 |
| 1979 | 2,544 | 224,635,398 | 1.1 | 1.1 |
| 1980 | 2,492 | 226,624,371 | 1.1 | 1.1 |
| 1981 | 2,668 | 229,487,512 | 1.2 | 1.2 |
| 1982 | 2,862 | 231,701,425 | 1.2 | 1.2 |
| 1983 | 2,866 | 233,781,743 | 1.2 | 1.2 |
| 1984 | 3,266 | 235,922,142 | 1.4 | 1.3 |
| 1985 | 3,612 | 238,005,715 | 1.5 | 1.5 |
| 1986 | 4,187 | 240,189,882 | 1.7 | 1.7 |
| 1987 | 3,907 | 242,395,034 | 1.6 | 1.6 |
| 1988 | 4,865 | 244,651,961 | 2.0 | 2.0 |
| 1989 | 5,035 | 247,001,762 | 2.0 | 2.0 |
| 1990 | 4,506 | 248,922,111 | 1.8 | 1.8 |
| 1991 | 5,215 | 253,088,068 | 2.1 | 2.0 |
| 1992 | 5,951 | 256,606,463 | 2.3 | 2.3 |
| 1993 | 7,382 | 260,024,637 | 2.8 | 2.8 |
| 1994 | 7,828 | 263,241,475 | 3.0 | 3.0 |
| 1995 | 8,000 | 266,386,596 | 3.0 | 3.0 |
| 1996 | 8,431 | 269,540,779 | 3.1 | 3.1 |
| 1997 | 9,099 | 272,776,678 | 3.3 | 3.3 |
| 1998 | 9,838 | 276,032,848 | 3.6 | 3.6 |
| 1999 | 16,849 | 279,040,168 | 6.0 | 6.1 |
| 2000 | 17,415 | 281,421,906 | 6.2 | 6.2 |
| 2001 | 19,394 | 284,968,955 | 6.8 | 6.8 |
| 2002 | 23,518 | 287,625,193 | 8.2 | 8.2 |
| 2003 | 25,785 | 290,107,933 | 8.9 | 8.9 |
| 2004 | 27,424 | 292,805,298 | 9.4 | 9.4 |
| 2005 | 29,813 | 295,516,599 | 10.1 | 10.1 |
| 2006 | 34,425 | 298,379,912 | 11.5 | 11.5 |
| 2007 | 36,010 | 301,231,207 | 12.0 | 11.9 |
| 2008 | 36,450 | 304,093,966 | 12.0 | 11.9 |
| 2009 | 37,004 | 306,771,529 | 12.1 | 11.9 |
| 2010 | 38,329 | 308,745,538 | 12.4 | 12.3 |
| 2011 | 41,340 | 311,591,917 | 13.3 | 13.2 |
| 2012 | 41,502 | 313,914,040 | 13.2 | 13.1 |
| 2013 | 43,982 | 316,128,839 | 13.9 | 13.8 |
| 2014 | 47,055 | 318,857,056 | 14.8 | 14.7 |
| 2015 | 52,404 | 321,418,820 | 16.3 | 16.3 |
| 2016 | 63,632 | 323,127,513 | 19.7 | 19.8 |
| 2017 | 70,237 | 325,719,178 | 21.6 | 21.7 |
| 2018 | 67,367 | 327,167,434 | 20.6 | 20.7 |
| 2019 | 70,630 | 328,239,523 | 21.5 | 21.6 |
| 2020 | 91,799 | 329,484,123 | 27.9 | 28.3 |
| Total | 1,106,859 |
Death rates by state and year
- Asterisks (*) indicate Health in LOCATION or Healthcare in LOCATION links in table below.
- NSD: Not sufficient data. NR: Not reported, or not recorded.
| Location | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 23.1 | 31.3 | 32.6 | 32.4 | 28.3 | 21.6 | 20.7 | 21.7 | 19.8 | 16.3 | 14.7 | 13.8 | 13.1 | 13.2 | 12.3 | 11.9 | 11.9 | 11.9 | 11.5 | 10.1 | 9.4 | 8.9 | 8.2 | 6.8 | 6.2 | 6.1 | |
| 25.0 | 33.9 | 31.5 | 30.1 | 22.3 | 16.3 | 16.6 | 18.0 | 16.2 | 15.7 | 15.2 | 12.7 | 12.1 | 11.8 | 11.8 | 13.6 | 13.0 | 11.1 | 8.7 | 6.3 | 6.4 | 4.4 | 4.8 | 4.9 | 4.5 | 3.9 | |
| 45.1 | 49.4 | 34.3 | 35.6 | 22.0 | 17.8 | 14.6 | 20.2 | 16.8 | 16.0 | 16.8 | 14.4 | 17.4 | 14.2 | 11.6 | 17.9 | 18.1 | 10.1 | 11.1 | 11.4 | 12.7 | 12.7 | 12.2 | 9.4 | 7.1 | 7.5 | |
| 32.6 | 36.1 | 37.2 | 38.7 | 35.8 | 26.8 | 23.8 | 22.2 | 20.3 | 19.0 | 18.2 | 18.7 | 17.7 | 16.9 | 17.5 | 16.1 | 13.5 | 15.7 | 14.9 | 14.1 | 13.7 | 12.7 | 12.0 | 10.9 | 10.6 | 10.6 | |
| 13.9 | 17.7 | 21.7 | 22.3 | 19.1 | 13.5 | 15.7 | 15.5 | 14.0 | 13.8 | 12.6 | 11.1 | 13.1 | 12.6 | 12.5 | 12.6 | 13.1 | 10.9 | 10.5 | 10.1 | 8.7 | 7.0 | 6.8 | 4.8 | 5.4 | 4.4 | |
| 21.7 | 27.9 | 26.9 | 26.6 | 21.8 | 15.0 | 12.8 | 11.7 | 11.2 | 11.3 | 11.1 | 11.1 | 10.3 | 10.7 | 10.6 | 10.7 | 10.4 | 10.5 | 9.6 | 9.0 | 8.8 | 8.9 | 8.7 | 3.6 | 5.8 | 8.1 | |
| 25.7 | 30.6 | 29.8 | 31.4 | 24.9 | 18.0 | 16.8 | 17.6 | 16.6 | 15.4 | 16.3 | 15.5 | 15.0 | 16.1 | 12.7 | 15.0 | 14.8 | 14.7 | 12.8 | 12.7 | 10.9 | 10.7 | 9.7 | 9.0 | 7.9 | 8.0 | |
| 26.2 | 35.2 | 40.3 | 42.3 | 39.1 | 34.7 | 30.7 | 30.9 | 27.4 | 22.1 | 17.6 | 16.0 | 12.1 | 11.2 | 10.1 | 11.0 | 10.7 | 12.2 | 11.5 | 8.5 | 9.6 | 8.8 | 10.3 | 8.8 | 9.2 | 9.0 | |
| 33.4 | 53.0 | 55.3 | 54.0 | 47.3 | 48.0 | 43.8 | 37.0 | 30.8 | 22.0 | 20.9 | 18.7 | 15.2 | 17.6 | 16.6 | 15.4 | 14.3 | 11.4 | 9.4 | 7.5 | 7.6 | 9.4 | 10.5 | 8.0 | 7.0 | 6.4 | |
| 21.3 | 31.7 | 35.2 | 37.5 | 35.0 | 25.5 | 22.8 | 25.1 | 23.7 | 16.2 | 13.2 | 12.6 | 13.3 | 15.4 | 16.4 | 16.7 | 16.2 | 15.4 | 14.4 | 13.5 | 13.2 | 12.4 | 11.8 | 10.9 | 7.4 | 6.4 | |
| 18.1 | 23.6 | 24.9 | 23.5 | 18.0 | 13.1 | 13.2 | 14.7 | 13.3 | 12.7 | 11.9 | 10.8 | 10.6 | 10.7 | 10.7 | 10.3 | 9.7 | 9.7 | 8.9 | 8.2 | 7.5 | 6.9 | 6.5 | 6.0 | 4.4 | 3.5 | |
| 21.0 | 21.4 | 18.6 | 17.3 | 18.3 | 15.9 | 14.3 | 13.8 | 12.8 | 11.3 | 10.9 | 11.0 | 11.0 | 12.4 | 10.9 | 9.6 | 9.0 | 10.0 | 6.4 | 9.4 | 8.0 | 7.1 | 6.1 | 6.2 | 5.1 | 6.5 | |
| 17.3 | 20.5 | 20.7 | 19.0 | 15.9 | 15.1 | 14.6 | 14.4 | 15.2 | 14.2 | 13.7 | 13.4 | 11.9 | 12.9 | 11.8 | 11.6 | 9.8 | 8.6 | 9.3 | 8.1 | 7.4 | 7.9 | 9.1 | 7.8 | 5.1 | 5.3 | |
| 19.3 | 27.3 | 30.0 | 29.0 | 28.1 | 21.9 | 21.3 | 21.6 | 18.9 | 14.1 | 13.1 | 12.1 | 12.5 | 10.9 | 10.0 | 10.8 | 10.6 | 9.4 | 10.9 | 8.4 | 8.3 | 6.8 | 7.9 | 7.1 | 7.0 | 6.7 | |
| 25.7 | 34.2 | 41.0 | 43.0 | 36.7 | 26.6 | 25.6 | 29.4 | 24.0 | 19.5 | 18.2 | 16.6 | 16.0 | 15.3 | 14.4 | 14.0 | 13.2 | 12.4 | 11.8 | 9.8 | 8.8 | 7.1 | 4.8 | 4.7 | 3.5 | 3.2 | |
| 13.7 | 14.9 | 15.3 | 15.3 | 14.3 | 11.5 | 9.6 | 11.5 | 10.6 | 10.3 | 8.8 | 9.3 | 8.7 | 8.4 | 8.6 | 7.1 | 7.2 | 6.9 | 6.6 | 4.8 | 4.2 | 3.4 | 3.1 | 3.0 | 2.5 | 1.9 | |
| 19.7 | 22.8 | 26.5 | 24.3 | 17.4 | 14.3 | 12.4 | 11.8 | 11.1 | 11.8 | 11.7 | 12.0 | 11.5 | 10.1 | 9.6 | 11.1 | 8.0 | 10.0 | 9.5 | 9.1 | 8.5 | 7.1 | 6.4 | 5.3 | 4.0 | 3.4 | |
| 33.5 | 48.0 | 53.2 | 55.6 | 49.2 | 32.5 | 30.9 | 37.2 | 33.5 | 29.9 | 24.7 | 23.7 | 25.0 | 25.0 | 23.6 | 18.0 | 17.9 | 16.7 | 17.4 | 15.3 | 12.8 | 13.6 | 10.5 | 8.4 | 5.9 | 4.9 | |
| 33.5 | 50.6 | 54.5 | 55.9 | 42.7 | 28.3 | 25.4 | 24.5 | 21.8 | 19.0 | 16.9 | 17.8 | 12.3 | 13.5 | 13.2 | 13.1 | 14.9 | 18.8 | 16.5 | 14.7 | 12.1 | 12.1 | 8.3 | 6.0 | 5.6 | 4.3 | |
| 35.2 | 44.9 | 54.3 | 47.1 | 39.7 | 29.9 | 27.9 | 34.4 | 28.7 | 21.2 | 16.8 | 13.2 | 11.5 | 11.8 | 10.4 | 12.7 | 12.3 | 12.4 | 12.0 | 12.4 | 11.0 | 10.3 | 10.9 | 6.5 | 4.8 | 5.3 | |
| 26.9 | 39.3 | 40.3 | 42.8 | 44.6 | 38.2 | 37.2 | 36.3 | 33.2 | 20.9 | 17.4 | 14.6 | 13.7 | 11.7 | 11.0 | 12.5 | 11.8 | 13.2 | 13.2 | 11.4 | 11.9 | 13.8 | 12.9 | 11.5 | 11.3 | 11.4 | |
| 21.8 | 33.6 | 37.4 | 36.8 | 33.9 | 32.1 | 32.8 | 31.8 | 33.0 | 25.7 | 19.0 | 16.0 | 12.7 | 12.7 | 11.0 | 12.2 | 11.9 | 14.0 | 14.7 | 12.0 | 10.3 | 12.6 | 10.7 | 10.5 | 7.1 | 7.5 | |
| 19.1 | 28.9 | 30.7 | 31.5 | 28.6 | 24.4 | 26.6 | 27.8 | 24.4 | 20.4 | 18.0 | 15.9 | 13.5 | 14.3 | 13.9 | 14.5 | 12.4 | 12.2 | 11.7 | 9.8 | 8.7 | 7.6 | 7.5 | 6.2 | 5.6 | 4.6 | |
| 17.3 | 23.6 | 24.8 | 24.5 | 19.0 | 14.2 | 11.5 | 13.3 | 12.5 | 10.6 | 9.6 | 9.6 | 8.9 | 9.4 | 7.3 | 7.9 | 7.2 | 6.4 | 5.9 | 5.4 | 4.8 | 4.8 | 3.9 | 3.7 | 2.6 | 2.8 | |
| 18.6 | 25.3 | 27.6 | 28.4 | 21.1 | 13.6 | 10.8 | 12.2 | 12.1 | 12.3 | 11.6 | 10.8 | 10.7 | 10.7 | 11.4 | 11.2 | 10.5 | 11.0 | 12.1 | 8.8 | 8.2 | 7.5 | 6.6 | 6.2 | 4.2 | 3.2 | |
| 23.7 | 33.5 | 36.9 | 36.5 | 32.1 | 26.9 | 27.5 | 23.4 | 23.6 | 17.9 | 18.2 | 17.5 | 16.2 | 16.4 | 17.0 | 14.6 | 13.1 | 12.3 | 13.0 | 10.7 | 9.8 | 9.3 | 7.5 | 6.3 | 5.5 | 5.0 | |
| 15.3 | 17.1 | 19.4 | 19.5 | 15.6 | 14.1 | 12.2 | 11.7 | 11.7 | 13.8 | 12.4 | 14.5 | 11.9 | 14.4 | 12.9 | 14.6 | 14.1 | 12.8 | 10.2 | 10.1 | 10.9 | 10.6 | 8.7 | 6.2 | 4.5 | 4.6 | |
| 8.1 | 9.0 | 11.8 | 11.4 | 11.3 | 8.7 | 7.4 | 8.1 | 6.4 | 6.9 | 7.2 | 6.5 | 7.9 | 7.1 | 6.7 | 5.9 | 5.5 | 4.8 | 5.4 | 5.0 | 3.6 | 3.2 | 3.9 | 3.9 | 2.8 | 2.3 | |
| 35.9 | 38.1 | 30.3 | 29.2 | 26.0 | 20.1 | 21.2 | 21.6 | 21.7 | 20.4 | 18.4 | 21.1 | 21.0 | 22.8 | 20.7 | 20.1 | 19.2 | 18.9 | 18.0 | 18.7 | 16.0 | 15.2 | 14.8 | 12.3 | 13.7 | 11.5 | |
| 21.6 | 32.7 | 36.0 | 32.3 | 30.3 | 32.0 | 35.8 | 37.0 | 39.0 | 34.3 | 26.2 | 15.1 | 13.4 | 15.3 | 11.8 | 12.5 | 9.4 | 13.8 | 11.2 | 10.7 | 9.6 | 9.5 | 8.7 | 6.1 | 3.4 | 4.3 | |
| 20.2 | 28.3 | 31.6 | 32.4 | 32.1 | 31.7 | 33.1 | 30.0 | 23.2 | 16.3 | 14.0 | 14.5 | 13.7 | 11.3 | 9.8 | 3.0 | 8.0 | 8.4 | 9.7 | 9.4 | 6.8 | 8.3 | 9.3 | 8.1 | 7.5 | 6.5 | |
| 37.1 | 48.9 | 50.3 | 51.6 | 39.0 | 30.2 | 26.7 | 24.8 | 25.2 | 25.3 | 27.3 | 22.6 | 24.7 | 26.3 | 23.8 | 22.0 | 26.7 | 23.4 | 21.8 | 20.1 | 16.9 | 19.7 | 16.1 | 14.4 | 15.1 | 15.0 | |
| 21.3 | 31.1 | 31.4 | 28.7 | 25.4 | 18.2 | 18.4 | 19.4 | 18.0 | 13.6 | 11.3 | 11.3 | 10.4 | 9.7 | 7.8 | 8.0 | 8.5 | 8.6 | 8.6 | 4.8 | 4.3 | 5.0 | 4.8 | 5.6 | 4.0 | 5.0 | |
| 25.7 | 33.7 | 41.8 | 39.2 | 30.9 | 22.3 | 22.4 | 24.1 | 19.7 | 15.8 | 13.8 | 12.9 | 13.3 | 13.0 | 11.4 | 12.6 | 12.8 | 11.9 | 11.8 | 11.4 | 9.9 | 9.0 | 7.7 | 6.6 | 6.0 | 4.6 | |
| 14.8 | 16.4 | 19.8 | 17.2 | 15.6 | 11.4 | 10.2 | 9.2 | 10.6 | 8.6 | 6.3 | 2.8 | 3.1 | NSD | 3.4 | 4.4 | 7.4 | 4.8 | NR | NR | NR | 3.5 | NR | NR | NR | NR | |
| 27.2 | 41.6 | 45.6 | 48.1 | 47.2 | 38.3 | 35.9 | 46.3 | 39.1 | 29.9 | 24.6 | 20.8 | 18.9 | 17.7 | 16.1 | 10.9 | 15.1 | 13.9 | 13.2 | 10.9 | 9.9 | 6.8 | 8.2 | 6.5 | 5.0 | 4.2 | |
| 25.5 | 32.4 | 30.7 | 24.4 | 19.4 | 16.7 | 18.4 | 20.1 | 21.5 | 19.0 | 20.3 | 20.6 | 20.6 | 18.9 | 19.4 | 20.6 | 15.6 | 18.8 | 16.2 | 13.8 | 13.9 | 11.8 | 7.1 | 8.0 | 7.1 | 5.4 | |
| 33.5 | 40.8 | 31.1 | 26.8 | 18.7 | 14.0 | 12.6 | 12.4 | 11.9 | 12.0 | 12.8 | 11.3 | 12.5 | 13.5 | 12.9 | 12.9 | 11.8 | 13.2 | 12.9 | 10.4 | 10.0 | 9.8 | 8.9 | 6.9 | 6.0 | 6.1 | |
| 25.6 | 37.1 | 40.9 | 43.2 | 42.4 | 35.6 | 36.1 | 44.3 | 37.9 | 26.3 | 21.9 | 19.4 | 19.0 | 18.3 | 15.3 | 15.2 | 14.9 | 13.9 | 13.5 | 13.2 | 12.7 | 11.4 | 9.1 | 7.9 | 9.5 | 8.1 | |
| 28.0 | 37.5 | 38.1 | 41.7 | 38.2 | 29.5 | 30.1 | 31.0 | 30.8 | 28.2 | 23.4 | 22.4 | 18.2 | 17.7 | 15.5 | 14.8 | 17.3 | 12.4 | 16.4 | 14.3 | 9.8 | 13.7 | 9.3 | 10.2 | 7.0 | 5.5 | |
| 27.5 | 41.3 | 44.7 | 42.8 | 34.9 | 22.7 | 22.6 | 20.5 | 18.1 | 15.7 | 14.4 | 13.0 | 12.5 | 13.3 | 14.6 | 13.3 | 12.5 | 12.1 | 12.7 | 9.9 | 8.4 | 7.0 | 5.3 | 5.9 | 6.5 | 3.7 | |
| 11.9 | 11.2 | 11.3 | 12.6 | 10.3 | 10.5 | 6.9 | 8.5 | 8.4 | 8.4 | 7.8 | 6.9 | 5.5 | 7.1 | 6.3 | 6.7 | 7.3 | 4.1 | 5.1 | 5.5 | 5.8 | 3.3 | 3.1 | 3.2 | 2.8 | NR | |
| 35.2 | 52.3 | 56.0 | 56.6 | 45.6 | 31.2 | 27.5 | 26.6 | 24.5 | 22.2 | 19.5 | 18.1 | 17.6 | 17.2 | 16.9 | 15.2 | 14.8 | 15.8 | 16.0 | 14.5 | 12.8 | 11.3 | 8.5 | 7.3 | 6.9 | 6.1 | |
| 15.8 | 18.5 | 18.2 | 16.8 | 14.1 | 10.8 | 10.4 | 10.5 | 10.1 | 9.4 | 9.7 | 9.3 | 9.4 | 10.1 | 9.6 | 9.8 | 8.5 | 9.3 | 9.5 | 8.5 | 8.2 | 8.1 | 7.5 | 6.6 | 5.0 | 5.4 | |
| 20.3 | 21.4 | 19.8 | 21.1 | 20.5 | 18.9 | 21.2 | 22.3 | 22.4 | 23.4 | 22.4 | 22.1 | 23.1 | 19.5 | 16.9 | 19.1 | 19.0 | 21.3 | 19.1 | 19.3 | 16.3 | 16.1 | 14.0 | 10.4 | 10.4 | 10.6 | |
| 33.6 | 42.3 | 45.9 | 42.3 | 32.9 | 23.8 | 26.6 | 23.2 | 22.2 | 16.7 | 13.9 | 15.1 | 10.9 | 12.9 | 9.7 | 8.3 | 10.9 | 10.8 | 12.2 | 8.5 | 8.0 | 10.2 | 7.5 | 7.1 | 5.8 | 4.7 | |
| 17.6 | 28.5 | 28.8 | 30.5 | 26.6 | 18.3 | 17.1 | 17.9 | 16.7 | 12.4 | 11.7 | 10.2 | 8.9 | 9.7 | 6.8 | 8.5 | 9.0 | 8.9 | 8.0 | 7.5 | 7.3 | 7.2 | 6.8 | 6.2 | 5.6 | 5.0 | |
| 37.6 | 42.4 | 33.7 | 28.1 | 22.0 | 15.8 | 14.8 | 15.2 | 14.5 | 14.7 | 13.3 | 13.4 | 13.7 | 14.1 | 13.1 | 14.3 | 14.8 | 14.4 | 13.6 | 13.0 | 12.7 | 11.1 | 10.4 | 8.1 | 9.2 | 9.3 | |
| 43.2 | 60.7 | 64.3 | 63.6 | 58.1 | 43.2 | 35.4 | 44.0 | 38.8 | 18.6 | 14.2 | 15.0 | 12.6 | 13.5 | 12.9 | 4.1 | 9.6 | 10.8 | 17.8 | 13.7 | 15.5 | 18.1 | 10.9 | 16.2 | 13.4 | 8.3 | |
| 48.9 | 81.9 | 80.9 | 90.9 | 81.4 | 52.8 | 51.5 | 57.8 | 52.0 | 41.5 | 35.5 | 32.2 | 32.0 | 36.3 | 28.9 | 12.4 | 25.7 | 22.4 | 20.4 | 10.5 | 18.8 | 15.1 | 12.9 | 11.5 | 6.2 | 4.1 | |
| 19.8 | 30.6 | 31.8 | 31.6 | 27.7 | 21.1 | 19.2 | 21.2 | 19.3 | 15.5 | 15.1 | 15.0 | 12.2 | 12.1 | 10.9 | 10.9 | 10.6 | 11.1 | 10.6 | 9.3 | 7.9 | 7.0 | 6.2 | 5.0 | 4.6 | 4.0 | |
| 20.1 | 23.7 | 21.9 | 18.9 | 17.4 | 14.1 | 11.1 | 12.2 | 17.6 | 16.4 | 19.4 | 17.2 | 16.8 | 15.2 | 15.0 | 11.0 | 14.0 | 12.3 | 10.6 | 4.9 | 9.1 | 5.9 | 6.9 | 4.5 | 4.6 | 4.1 |
Death counts by state over time
Overall US totals by year from CDC, followed by breakdown by state by year.[1][12]
| 1999 | 2005 | 2014 | 2015 | 2016 | |
|---|---|---|---|---|---|
| Total | 16,801 | 29,736 | 46,959 | 52,279 | 63,363 |
| 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | |
|---|---|---|---|---|---|---|
| Total | 69,927 | 67,113 | 70,319 | 91,375 | 106,249 | 107,941 |
Location links below are "Category:Health in LOCATION" links. See overall category.
| Location | 1999 | 2005 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 46 | 79 | 124 | 122 | 128 | 147 | 110 | 132 | 160 | 260 | 254 | |
| 169 | 283 | 723 | 736 | 756 | 835 | 775 | 768 | 1,029 | 1,408 | 1,492 | |
| 113 | 269 | 1,211 | 392 | 401 | 446 | 444 | 388 | 546 | 637 | 617 | |
| 511 | 794 | 356 | 1,274 | 1,382 | 1,532 | 1,670 | 1,907 | 2,550 | 2,730 | 2,664 | |
| 2,662 | 3,214 | 4,521 | 4,659 | 4,654 | 4,868 | 5,348 | 6,198 | 8,908 | 10,901 | 10,952 | |
| 349 | 608 | 899 | 869 | 942 | 1,015 | 995 | 1,079 | 1,492 | 1,887 | 1,811 | |
| 310 | 295 | 623 | 800 | 971 | 1,072 | 1,069 | 1,214 | 1,371 | 1,552 | 1,482 | |
| 50 | 62 | 189 | 198 | 282 | 338 | 401 | 435 | 444 | 513 | 549 | |
| 997 | 2,371 | 2,634 | 3,228 | 4,728 | 5,088 | 4,698 | 5,268 | 7,231 | 7,827 | 7,551 | |
| 283 | 738 | 1,206 | 1,302 | 1,394 | 1,537 | 1,404 | 1,408 | 1,916 | 2,500 | 2,687 | |
| 80 | 126 | 157 | 169 | 191 | 203 | 213 | 242 | 274 | 269 | 284 | |
| 53 | 141 | 264 | 309 | 314 | 341 | 287 | 352 | 432 | 475 | 469 | |
| 64 | 109 | 212 | 218 | 243 | 236 | 250 | 265 | 287 | 354 | 385 | |
| 825 | 1,067 | 1,705 | 1,835 | 2,411 | 2,778 | 2,722 | 2,790 | 3,549 | 3,762 | 3,849 | |
| 191 | 610 | 1,172 | 1,245 | 1,526 | 1,852 | 1,629 | 1,699 | 2,321 | 2,811 | 2,682 | |
| 89 | 241 | 332 | 329 | 313 | 333 | 345 | 403 | 490 | 680 | 754 | |
| 197 | 638 | 1,077 | 1,273 | 1,419 | 1,566 | 1,315 | 1,380 | 2,083 | 2,381 | 2,271 | |
| 188 | 661 | 777 | 861 | 996 | 1,108 | 1,140 | 1,267 | 1,896 | 2,463 | 2,376 | |
| 488 | 780 | 1,289 | 1,724 | 2,227 | 2,168 | 2,241 | 2,210 | 2,302 | 2,585 | 2,642 | |
| 629 | 656 | 1,070 | 1,285 | 2,044 | 2,247 | 2,324 | 2,369 | 2,771 | 2,737 | 2,573 | |
| 67 | 163 | 216 | 269 | 353 | 424 | 345 | 371 | 496 | 611 | 707 | |
| 460 | 985 | 1,762 | 1,980 | 2,347 | 2,694 | 2,591 | 2,385 | 2,759 | 3,089 | 2,997 | |
| 136 | 282 | 517 | 581 | 672 | 733 | 636 | 792 | 1,050 | 1,356 | 1,384 | |
| 276 | 608 | 1,067 | 1,066 | 1,371 | 1,367 | 1,610 | 1,583 | 1,875 | 2,155 | 2,192 | |
| 87 | 248 | 336 | 351 | 352 | 354 | 310 | 394 | 586 | 787 | 758 | |
| 41 | 96 | 125 | 138 | 119 | 119 | 125 | 143 | 162 | 199 | 208 | |
| 366 | 1,000 | 1,358 | 1,567 | 1,956 | 2,414 | 2,259 | 2,266 | 3,146 | 3,981 | 4,310 | |
| 12 | 12 | 43 | 61 | 77 | 68 | 70 | 82 | 114 | 124 | 148 | |
| 39 | 86 | 125 | 126 | 120 | 152 | 138 | 161 | 214 | 214 | 225 | |
| 54 | 142 | 334 | 422 | 481 | 467 | 452 | 407 | 393 | 441 | 486 | |
| 557 | 823 | 1,253 | 1,454 | 2,056 | 2,685 | 2,900 | 2,805 | 2,840 | 3,056 | 2,985 | |
| 266 | 373 | 547 | 501 | 500 | 493 | 537 | 599 | 784 | 1,052 | 1,024 | |
| 227 | 457 | 545 | 619 | 665 | 676 | 688 | 647 | 832 | 949 | 1,003 | |
| 959 | 944 | 2,300 | 2,754 | 3,638 | 3,921 | 3,697 | 3,617 | 4,965 | 5,842 | 6,358 | |
| 467 | 1,243 | 2,744 | 3,310 | 4,329 | 5,111 | 3,980 | 4,251 | 5,204 | 5,397 | 5,144 | |
| 178 | 478 | 777 | 725 | 813 | 775 | 716 | 645 | 762 | 960 | 1,196 | |
| 210 | 386 | 522 | 505 | 506 | 530 | 547 | 615 | 803 | 1,171 | 1,363 | |
| 990 | 1,613 | 2,732 | 3,264 | 4,627 | 5,388 | 4,415 | 4,377 | 5,168 | 5,449 | 5,169 | |
| 58 | 156 | 247 | 310 | 326 | 320 | 317 | 307 | 397 | 455 | 424 | |
| 147 | 427 | 701 | 761 | 879 | 1,008 | 1,125 | 1,127 | 1,739 | 2,138 | 2,279 | |
| 17 | 40 | 63 | 65 | 69 | 73 | 57 | 86 | 83 | 105 | 95 | |
| 344 | 872 | 1,269 | 1,457 | 1,630 | 1,776 | 1,823 | 2,089 | 3,034 | 3,813 | 3,825 | |
| 1,087 | 1,910 | 2,601 | 2,588 | 2,831 | 2,989 | 3,005 | 3,136 | 4,172 | 4,984 | 5,489 | |
| 205 | 438 | 603 | 646 | 635 | 650 | 624 | 571 | 622 | 662 | 627 | |
| 366 | 581 | 980 | 1,039 | 1,405 | 1,507 | 1,448 | 1,547 | 2,240 | 2,626 | 2,496 | |
| 29 | 53 | 83 | 99 | 125 | 134 | 153 | 133 | 190 | 252 | 276 | |
| 555 | 850 | 979 | 1,094 | 1,102 | 1,169 | 1,164 | 1,259 | 1,733 | 2,264 | 2,725 | |
| 451 | |||||||||||
| 212 | 518 | 853 | 878 | 1,074 | 1,177 | 1,079 | 1,201 | 1,531 | 1,775 | 1,792 | |
| 75 | 184 | 627 | 725 | 884 | 974 | 856 | 870 | 1,330 | 1,501 | 1,335 | |
| 20 | 26 | 109 | 96 | 99 | 69 | 66 | 79 | 99 | 109 | 126 |
For convenience, and as a geographic aid, the "Category:Health in STATE" links are also in this map. Click on any state.

Timeline by drug
Opioid charts

Opioids were involved in around 80,400 of the around 106,700 deaths in 2021.[8] See map higher up for states with the highest overdose death rates.








Death rates by race and ethnicity
Rate timeline by sex
Comparisons to other countries



Below is the overdose or drug-related death rate per 1 million population (unadjusted), 2022, by country or region.[22]

Comparisons to other countries in Europe
Rates per 100,000 adults
- Location links are "Healthcare in LOCATION" links.
| Location | Year | Females | Males | Total |
|---|---|---|---|---|
| 2022 | 1.8 | 6.5 | 4.2 | |
| 2020 | 0.7 | 3.4 | 2.1 | |
| 2022 | 0.1 | 0.8 | 0.4 | |
| 2022 | 1.3 | 7.1 | 4.2 | |
| 2022 | 0.3 | 1.3 | 0.8 | |
| 2022 | 0.6 | 1.2 | 0.9 | |
| 2021 | 1.9 | 6 | 4 | |
| 2022 | 3.4 | 15.5 | 9.5 | |
| 2022 | 3.3 | 10.6 | 7 | |
| 2016 | 0.3 | 1.6 | 0.9 | |
| 2022 | 1 | 4.9 | 3 | |
| 2020 | 1 | 5.8 | 3.4 | |
| 2021 | 0.3 | 0.9 | 0.6 | |
| 2020 | 6.4 | 13 | 9.7 | |
| 2022 | 0.2 | 1.3 | 0.8 | |
| 2022 | 1.2 | 9.6 | 5.3 | |
| 2022 | 1 | 8.6 | 4.7 | |
| 2022 | 0.5 | 3.1 | 1.8 | |
| 2020 | 0.6 | 4.3 | 2.6 | |
| 2022 | 1.3 | 4 | 2.6 | |
| 2022 | 5.3 | 11.8 | 8.6 | |
| 2021 | 0.5 | 1.1 | 0.8 | |
| 2021 | 0.4 | 1.9 | 1.1 | |
| 2022 | 0.1 | 0.3 | 0.2 | |
| 2021 | 0.3 | 1.2 | 0.7 | |
| 2022 | 1.6 | 7.4 | 4.6 | |
| 2021 | 0.7 | 3.4 | 2.1 | |
| 2022 | 3.5 | 10.2 | 7 | |
| 2022 | 0.1 | 0.7 | 0.4 |
Counts
- Location links are "Healthcare in LOCATION" links.
| Location | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 |
|---|---|---|---|---|---|---|
| 248 | 235 | 191 | 196 | 184 | 154 | |
| 172 | 168 | 152 | 148 | |||
| 20 | 20 | 24 | 11 | 24 | 18 | |
| 102 | 77 | 99 | 97 | 85 | 65 | |
| 5 | 10 | 6 | 5 | 12 | 16 | |
| 64 | 64 | 58 | 42 | 39 | 42 | |
| 184 | 199 | 203 | 183 | 239 | ||
| 82 | 39 | 33 | 27 | 39 | 110 | |
| 250 | 287 | 258 | 234 | 261 | 200 | |
| 417 | ||||||
| 1,631 | 1,466 | 1,581 | 1,398 | 1,276 | 1,272 | |
| 230 | 230 | 274 | 255 | |||
| 42 | 48 | 43 | 33 | 33 | ||
| 322 | 298 | 266 | 235 | |||
| 298 | 296 | 309 | 374 | 336 | 297 | |
| 63 | 17 | 21 | 12 | 20 | 22 | |
| 87 | 62 | 47 | 52 | 59 | 83 | |
| 8 | 5 | 6 | 8 | 4 | 8 | |
| 5 | 9 | 4 | 3 | 5 | ||
| 332 | 298 | 295 | 252 | 224 | 262 | |
| 321 | 241 | 324 | 275 | 286 | 247 | |
| 289 | 229 | 212 | 199 | 202 | ||
| 81 | 63 | 72 | 55 | 51 | ||
| 27 | 30 | 33 | 45 | 26 | 32 | |
| 28 | 37 | 34 | 32 | 19 | ||
| 66 | 65 | 70 | 74 | 59 | 47 | |
| 820 | 774 | 546 | 450 | 437 | ||
| 519 | 450 | 524 | 555 | 583 | 643 | |
| 246 | 270 | 314 | 342 | 657 | 941 | |
| 3,284 |






