Vila Velha do Cassiporé is located in a territory which was disputed between France and Brazil.[4] The region attracted escaped Brazilian slaves.[5] In the 19th century, gold was discovered in the Cassiporé River. In 1900, the territory was awarded to Brazil.[4]
In 1951, Vila Velha do Cassiporé became a district of the municipality of Oiapoque.[2] In 1957, the population of the village was estimated at about 250 people.[4] In 1999, INCRA established an agricultural community in Vila Velha.[6] In 2016, the village was recognised as a Quilombo settlement,[7] and has been allocated a territory comparable to the indigenous territories.[8]
Vila Velha do Cassiporé has a school and a clinic, however a 2018 investigation revealed that both were not meeting basic requirements.[9] The village used to accessible by boat only which amounted to a day's journey from Oiapoque. In 2015, a road opened connecting the village to the BR-156 highway.[3] The economy is mainly based on agriculture. The main export products are watermelons and cocoa.