Vipadenant

Vipadenant
Clinical data
Other names	BG-14; BG14; BIIB-014; BIIB014; BIIB14; CEB-4520; V-2006; VER-11135; VER-A00-11; VER-A00049; VER-ADO-49; VR-2006
Routes of; administration	Oral
Drug class	Adenosine A2A receptor antagonist; Antiparkinsonian agent
ATC code	None;
Identifiers
	IUPAC name 3-[(4-amino-3-methylphenyl)methyl]-7-(furan-2-yl)triazolo[4,5-d]pyrimidin-5-amine;
CAS Number	442908-10-3;
PubChem CID	21874557;
IUPHAR/BPS	5612;
DrugBank	DB06625;
ChemSpider	10620930;
UNII	LDR3USH1NJ;
KEGG	D09991;
ChEMBL	ChEMBL447664;
PDB ligand	9XT (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID90196103 ;
Chemical and physical data
Formula	C16H15N7O
Molar mass	321.344 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=CC(=C1)CN2C3=NC(=NC(=C3N=N2)C4=CC=CO4)N)N;
	InChI InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20); Key:HQSBCDPYXDGTCL-UHFFFAOYSA-N;

Vipadenant (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name BIIB014 and others) is an adenosine A_2A receptor antagonist which was under development for the treatment of Parkinson's disease and cancer but was never marketed.^[1]^[2]^[3]^[4] It is taken orally.^[1] The drug was first described in the scientific literature by 2006.^[5]^[6] It was under development by Vernalis, Biogen, and Juno Therapeutics.^[1]^[2] Vipadenant reached phase 2 clinical trials prior to the discontinuation of its development.^[1]^[2]

Other namesBG-14; BG14; BIIB-014; BIIB014; BIIB14; CEB-4520; V-2006; VER-11135; VER-A00-11; VER-A00049; VER-ADO-49; VR-2006

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Clinical data

Other names	BG-14; BG14; BIIB-014; BIIB014; BIIB14; CEB-4520; V-2006; VER-11135; VER-A00-11; VER-A00049; VER-ADO-49; VR-2006
Routes of administration	Oral^[1]
Drug class	Adenosine A_2A receptor antagonist; Antiparkinsonian agent
ATC code	None
Identifiers
IUPAC name 3-[(4-amino-3-methylphenyl)methyl]-7-(furan-2-yl)triazolo[4,5-d]pyrimidin-5-amine
CAS Number	442908-10-3
PubChem CID	21874557
IUPHAR/BPS	5612
DrugBank	DB06625
ChemSpider	10620930
UNII	LDR3USH1NJ
KEGG	D09991
ChEMBL	ChEMBL447664
PDB ligand	9XT (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID90196103
Chemical and physical data
Formula	C₁₆H₁₅N₇O
Molar mass	321.344 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C=CC(=C1)CN2C3=NC(=NC(=C3N=N2)C4=CC=CO4)N)N
InChI InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20) Key:HQSBCDPYXDGTCL-UHFFFAOYSA-N