WAY-181187

WAY-181187 is a high affinity and selective 5-HT₆ receptor full agonist.^[1][2] It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas.^[1][3] WAY-181187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder,^[1][4] though it has also been shown to impair cognition and memory.^[3][5]

ATC code

• none

CAS Number

• 554403-49-5

PubChem CID

• 10150497

IUPHAR/BPS

• 3240

Quick facts Clinical data, ATC code ...

WAY-181187

Clinical data
ATC code	none
Identifiers
IUPAC name 2-(1-{6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl}-1H-indol-3-yl)ethan-1-amine
CAS Number	554403-49-5
PubChem CID	10150497
IUPHAR/BPS	3240
ChemSpider	8326005
UNII	WXE3H7W295
ChEMBL	ChEMBL392760 Y
CompTox Dashboard (EPA)	DTXSID50204011
Chemical and physical data
Formula	C15H13ClN4O2S2
Molar mass	380.87 g·mol−1
3D model (JSmol)	Interactive image
SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
InChI InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2 Key:RYBOXBBYCVOYNO-UHFFFAOYSA-N

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