Wikipedia talk:WikiProject Medicine/Archive 65
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Medical FA maintenance
@Boghog:, @Jfdwolff:, @MastCell:, @Graham Beards:
I'm here with a plea, wearing two different hats-- medical editor, as well as former Featured article candidates (FAC) delegate and active Featured article review (FAR) participant, who resigned from FAC to resume medical editing.
The FAR team is working now on developing the next phase of review of older Featured articles. As we have begun to process through a sandbox listing of older FAs, I am consistently finding citation issues in the medical featured articles (FAs).
Some history: User:Diberri created the citation template filling tool that is now maintained by Boghog. It was for many years used by almost all medical editors, to the extent that it became the "house style" for most medical content. It uses a style that mimics author name formatting in PubMed, and avoids lots of template clutter with one author parameter; it also avoids clunky punctuation used by some other citation styles. It also avoided lengthy citations in our densely-cited medical articles by listing all authors if there were five or less, while truncating the authors to the first three with an et al when there were six or more authors. I just cleaned up Alzheimer's disease, so an (almost) clean sample can be seen there.
On any article, we should avoid altering citation style, per WP:CITEVAR. But with Featured articles, a consistent citation style is a requirement for FA status; when adding or updating citations, the established style must be maintained.
As I'm processing through the medical FAs, I'm finding that almost all of them used the Diberri format, but they have deteriorated over the years into a mess of citation styles-- some of them now having five or six different styles of citation! Some of this is because editors aren't aware they need to maintain consistency, and some is because there is apparently a tool in the edit window that uses some other style than we have always used. And some of it may be because Boghog made subtle changes to the Diberri tool; I'm not sure I follow all of that.
Could we please be aware of what the Diberri style is, and take care to maintain a consistent citation style in our medical Featured articles? I don't believe (not sure) that a consistent style is a requirement for Good articles, as it is for FA, but it makes sense to use one style on medical content, particularly since we historically had a house style, and we have a tool that generates it.
As we get further along on processing through old FAs, I will separately bring in WP:MED for whichever medical FAs appear to need updates other than in this area of citation consistency. Regards, SandyGeorgia (Talk) 22:59, 5 May 2015 (UTC)
- I believe there's also a bot or script that goes around and "fixes" (read: screws up) Diberri formatting, e.g., by adding all of the authors' names. WhatamIdoing (talk) 23:59, 5 May 2015 (UTC)
- Correct. I am able to revert them on the FAs I have watchlisted, but I can't stop them from changing thousands of other medical articles (they chunk up the citation parameters, making editing around the templates harder). SandyGeorgia (Talk) 01:18, 6 May 2015 (UTC)
- ive seen those errors too --Ozzie10aaaa (talk) 09:32, 6 May 2015 (UTC)
- I like the house style. I hate these bots that go around and make unneeded changes to reference style and clutter up my watch list / hide prior vandalism from my watch list.
- I often use the style that the tool in the edit box provides because it is easier. I am supportive of changing that tool to follow the Dibierri style or at least allow users to set that style as their preference. User:Boghog what would be require to do this?
- Doc James (talk · contribs · email) 14:54, 6 May 2015 (UTC)
- Thanks, Doc! Two followup items:
- I have never known where to find this "tool in the edit box" you reference. I looked for it yesterday, and didn't find a tool that produces the output you often use for citation templates. Can someone point me towards it? Sorry, techno-dumbie here.
- On questions for Boghog (to whom we should all express immense gratitude!!!!), I am unclear on just what the tool is currently doing. I don't really know why it's using vcite2, or vauthors, or what it's doing with et al, and how I can convince the new tool to just return a cite journal template that matches the older Diberri style used on most FAs, or even if I should be doing that. In other words, until I understand what the current version of the tool is doing, I'm not sure what our "house style" is any more ... I know what it was years ago ... and if we are now changing our "house style", then we've got quite a task ahead of us on FA maintenance.
- Bst, SandyGeorgia (Talk) 15:29, 6 May 2015 (UTC)
- It may be browser dependent. On Firefox, at the top of the edit window in edit mode you get a bunch of mysterious "icons". The open book does a fairly straightforward ref ref & is useful. The {{ }} opens a line of tabs below for Cite web, cite book etc. When you click on one a form thing opens up, which takes PMID & will fill in the rest, but not in Dubarri style. I should add that (having done several FAs with no citation templates), when I came to do Pancreatic cancer I tried to follow Med house style, but could never exactly work out how to do so, & all the citations were worked over (unasked for by me, & by an editor who I think is highly medically qualified & arguably would be better employed writing text). Johnbod (talk) 15:43, 6 May 2015 (UTC)
- Seen here WP:MEDHOW Doc James (talk · contribs · email) 15:53, 6 May 2015 (UTC)
- Ah, ha! I see the key words are "By using the toolbar (nb: this doesn't work in Internet Explorer) ... ". I will look later today from another computer. Thanks both! SandyGeorgia (Talk) 15:58, 6 May 2015 (UTC)
- Nothing works in IE :-) Doc James (talk · contribs · email) 16:01, 6 May 2015 (UTC)
- OK ... I went to Firefox, found that tool (and the difference vs. IE), and see where some of our issues are coming from. On IE, for example, that tool is adding the awful cite|pmid (which is known to return errors). On Firefox, I don't understand the duplicate punctuation it returns; continued below with samples for discussion. SandyGeorgia (Talk) 17:45, 8 May 2015 (UTC)
- Nothing works in IE :-) Doc James (talk · contribs · email) 16:01, 6 May 2015 (UTC)
- Ah, ha! I see the key words are "By using the toolbar (nb: this doesn't work in Internet Explorer) ... ". I will look later today from another computer. Thanks both! SandyGeorgia (Talk) 15:58, 6 May 2015 (UTC)
- Seen here WP:MEDHOW Doc James (talk · contribs · email) 15:53, 6 May 2015 (UTC)
- It may be browser dependent. On Firefox, at the top of the edit window in edit mode you get a bunch of mysterious "icons". The open book does a fairly straightforward ref ref & is useful. The {{ }} opens a line of tabs below for Cite web, cite book etc. When you click on one a form thing opens up, which takes PMID & will fill in the rest, but not in Dubarri style. I should add that (having done several FAs with no citation templates), when I came to do Pancreatic cancer I tried to follow Med house style, but could never exactly work out how to do so, & all the citations were worked over (unasked for by me, & by an editor who I think is highly medically qualified & arguably would be better employed writing text). Johnbod (talk) 15:43, 6 May 2015 (UTC)
- Thanks, Doc! Two followup items:
- ive seen those errors too --Ozzie10aaaa (talk) 09:32, 6 May 2015 (UTC)
- Correct. I am able to revert them on the FAs I have watchlisted, but I can't stop them from changing thousands of other medical articles (they chunk up the citation parameters, making editing around the templates harder). SandyGeorgia (Talk) 01:18, 6 May 2015 (UTC)
The problem is that we have the following competing priorities:
- compact Diberri style citation templates whose continued use is supported by WP:CITEVAR (note: CITEVAR applies both to the rendered citation as well as the raw citation wikitext)
- the defacto {{cite journal}} metadata driven first1, last1, ... ad nauseam house style that is reinforced by RefToolbar
- medical translation project which is facilitated by seamless transfer of citation templates between languages
{{vcite2 journal}} was designed to be both compact (addresses priority #1) and generate clean metadata (priority #2). The reason that I modified the Template Filling Tool to generate {{vcite2 journal}} instead of {{cite journal}} is (1) as a deterrence to bots that try to substitute |author= with first1, last1, ... parameter bloat, (2) suppress citation error messages, and (3) generate clean metadata. Personally I think the value of citation metadata is grossly overrated, but some editors insist on it. I also changed the Template Filling Tool default to not use "et al." (i.e., include all authors) to prevent citation errors from being generated. My short term plan is to (1) add "et al." support to {{vcite2 journal}} and then (2) change the Filling Tool default back to "et al.". Hopefully this will address the FA related issues. Longer term, if |vauthors= support were added directly to {{cite journal}} and RefToolbar, this would also address priority #3. Then everyone should be happy. Note that I am really busy in real life and will try to implement some improvements mentioned above this weekend when I have more time. Boghog (talk) 19:30, 6 May 2015 (UTC)
- Yes we do need a templates that work in all other languages which cite journal more or less does. Thus I am not a big fan of vcite2 journal. Doc James (talk · contribs · email) 19:43, 6 May 2015 (UTC)
- No one is willing to compromise around here. Seriously, you can't be bothered to substitute "vcite2"/"vauthors" with "cite"/"author"? It is a trivial search and replace. We can port {{vcite2 journal}} to all other languages. It is already ported to six languages. I am really tired hearing about this complaint to the point where I am seriously considering porting to this template to all other languages which will completely nullify this objection. Boghog (talk) 20:06, 6 May 2015 (UTC)
- Yup if you port it to all other languages I will be happy with this template being used :-) I have struggled with porting templates. We currently have nearly 200 articles we are translating from. From time to time I update them to a newer version. Updating all the content to a newer version requires multiple steps and takes me many hours. So I appreciate people working with me on this.Doc James (talk · contribs · email) 22:58, 6 May 2015 (UTC)
- No one is willing to compromise around here. Seriously, you can't be bothered to substitute "vcite2"/"vauthors" with "cite"/"author"? It is a trivial search and replace. We can port {{vcite2 journal}} to all other languages. It is already ported to six languages. I am really tired hearing about this complaint to the point where I am seriously considering porting to this template to all other languages which will completely nullify this objection. Boghog (talk) 20:06, 6 May 2015 (UTC)
- Yes we do need a templates that work in all other languages which cite journal more or less does. Thus I am not a big fan of vcite2 journal. Doc James (talk · contribs · email) 19:43, 6 May 2015 (UTC)
- SandyGeorgia Thanks for the heads up. I am finding very little time to edit but I will see if I can clean up the FAs that I was involved in (coeliac disease, thyrotoxic periodic paralysis, meningitis). JFW | T@lk 20:29, 6 May 2015 (UTC)
- Also: write good WP:TemplateData first, before porting anything. The basic structure won't change between wikis. WhatamIdoing (talk) 00:56, 7 May 2015 (UTC)
- Trappist the monk has now added
|vauthors=support to the Module:Citation/CS1 sandbox (see discussion).|vauthors=has also been extended to accept "et al" in the author list. In a few weeks when this goes live, {{cite journal}}, {{cite book}}, etc. templates will all support|vauthors=. I will then change the Wikipedia template filling tool back to its previous defaults, except of course that the name of the author parameter will be|vauthors=instead of|author=. The only remaining issues are (1) convince the maintainers of RefToolbar to add the option of outputting|vauthors=instead of "first1, last1, ..." parameters and (2) convince the maintainer of Citation Bot not to add "first1, last1, ..." parameters to citations that contain|vauthors=. Finally there will no longer be a need for {{vcite2 journal}} since the same functionality will be found in the standard {{cite journal}} template. - I think this is fantastic news that should solve a large number of problems. We should thank Trappist the monk for doing this. Boghog (talk) 06:19, 8 May 2015 (UTC)
- Boghog, I hope you understand how seriously I appreciate your work (and the fact that you communicate your work in English), but I am still struggling. I tried to put together some samples for discussion (see my sandbox), but they don't even render as I type them, so I don't know what to do next to try to sort out the remaining issues/confusion I still have. The bottom line for me is that I'm not complaining about anything you do, but I don't know yet a) if we still have a house style, b) what it is, and c) what to do about citation consistency in our old FAs. And I owe LeadSongDog an answer on my talk, which I thought I was going to sort with samples, that I can't even make work. I know you are busy, but if you have a moment, could you help me sort the problems with the citations rendering in my sandbox different than they are typed? I am just trying to figure out how to get our FAs to have consistent citations for FAR review ... and Trappist doesn't communicate in English. SandyGeorgia (Talk) 18:18, 8 May 2015 (UTC)
- You know, the more I look at this, the more I'm confused. Why do we even care which format is rendered, if the template is only going to change next week or next month anyhow? We should just focus on the values. Sooner or later it'll all wind up on wikidata anyhow. LeadSongDog come howl! 19:07, 8 May 2015 (UTC)
- Don't count on that last bit. Johnbod (talk) 19:42, 8 May 2015 (UTC)
- There are two separate issues here. The first is the output of the Template Filling Tool which I have control over. As I stated above, once the changes in {{cite journal}} go live, I will change the default output of the tool back to its original defaults. The second issue is how {{cite journal}} render citations which I have no control over. In the first example in the sandbox, the last comma as well as the italics and period after "et al." is stripped from the author list. In the Vancouver guideline examples, a comma should be included between the last displayed author name and "et al." and the final period should be included. Therefore I would support modifying {{cite journal}} so that the final comma and period are displayed. The italics is not part of the standard Vancouver style and most journal do not include it. So, in summary, would it be acceptable if {{cite journal}} were modified so that the final comma and period are displayed but not the italics? Boghog (talk) 20:12, 8 May 2015 (UTC)
- The "Diberri" citation style is a hybrid. It follows Vancouver style author format and relies on {{cite journal}} for everything else. The complication is that changes in how "et al" is rendered by {{cite journal}} have been made. While this could be considered a violation of CITEVAR, because the change was made in the template, the change is at least uniformly applied across all articles that use this template. The only way to insure that rendering of a citation will not change over time is to use non-templated citations. Boghog (talk) 21:16, 8 May 2015 (UTC)
The only way to insure that rendering of a citation will not change over time is to use non-templated citations.
shhhhh ... one of us realized that almost ten years ago. SandyGeorgia (Talk) 21:21, 8 May 2015 (UTC)
- Don't count on that last bit. Johnbod (talk) 19:42, 8 May 2015 (UTC)
- You know, the more I look at this, the more I'm confused. Why do we even care which format is rendered, if the template is only going to change next week or next month anyhow? We should just focus on the values. Sooner or later it'll all wind up on wikidata anyhow. LeadSongDog come howl! 19:07, 8 May 2015 (UTC)
- Boghog, I hope you understand how seriously I appreciate your work (and the fact that you communicate your work in English), but I am still struggling. I tried to put together some samples for discussion (see my sandbox), but they don't even render as I type them, so I don't know what to do next to try to sort out the remaining issues/confusion I still have. The bottom line for me is that I'm not complaining about anything you do, but I don't know yet a) if we still have a house style, b) what it is, and c) what to do about citation consistency in our old FAs. And I owe LeadSongDog an answer on my talk, which I thought I was going to sort with samples, that I can't even make work. I know you are busy, but if you have a moment, could you help me sort the problems with the citations rendering in my sandbox different than they are typed? I am just trying to figure out how to get our FAs to have consistent citations for FAR review ... and Trappist doesn't communicate in English. SandyGeorgia (Talk) 18:18, 8 May 2015 (UTC)
- Trappist the monk has now added
- Also: write good WP:TemplateData first, before porting anything. The basic structure won't change between wikis. WhatamIdoing (talk) 00:56, 7 May 2015 (UTC)
Reboot
OK, if I'm reading everything above correctly, our citations will be in flux until a) something that Trappist did somewhere goes live, and b) Boghog adapts the filling tool. If I am understanding everything (not likely!!!) so far, the filling tool will be adjusted to:
- List all authors if there are five or less, and truncate to three plus et al if there are six or more.
- No longer italicize et al.
- Place a comma after the last author, before the et al.
Then, I still have the following questions:
- Will/does this mean that the Diberri/Boghog tool will still output vcite2 and vauthors or does it go back to plain old cite journal and author? (I have been stripping the v and the 2 when articles don't use them.)
- Will/does this mean we will need to retroactively switch old FAs that use either vcite to cite to one or the other? If so, can we get a bot to do that?
On top of those issues, we have other WP:CITEVAR issues. For example, to answer LeadSongDog's query, because I have since, like, forever HATED these eternal alterations in the citation templates (they are at the whim of these developers, and just when the FA author gets their ducks all in a row, some metadata person changes everything and citations go to heck, which is where we are now), I will always defend the right of the main/first developers of any article to maintain their original style (CITEVAR) if they disagree with what the rest of us decide. I think that's all of my questions and confusion, but don't count on it :) Bst, SandyGeorgia (Talk) 20:59, 8 May 2015 (UTC)
- (ec) The tool will return to its default (list all authors if there are five or less, and truncate to three plus et al if there are six or more). However additional changes to {{cite journal}} will be required to place a comma between the last displayed author and et al. After the changes, {{vcite2 journal}} will be replaced by {{cite journal}} but
|vauthors=will be retained. Please note for all of this to work, it is essential that|vauthors=and not|author=be used. The format of the rendered citation and metadata are two completely different issues. Changes in one can be made that does not affect the other. The advantage of the|vauthors=parameter is that it will render the authors in Vancouver style and generate clean metadata without the need for explicit "first1, last1, ..." parameters. Boghog (talk) 21:36, 8 May 2015 (UTC) - If there is consensus, a bot could easily replace {{vcite journal}}/
|author=with {{cite journal}}/|vauthors=and replace {{vcite2 journal}} with {{cite journal}}. Boghog (talk) 21:44, 8 May 2015 (UTC)
- Being a stylistic pig, I have no strong opinions about any of this except to request that you please don't take Dberri offline again. I'm too stupid to learn any other way of doing references. thanks. Formerly 98 talk|contribs|COI Statement 21:33, 8 May 2015 (UTC)
- I will try my best keeping Dberri online. The only reason it went off-line is that Dberri no longer had time to support it. Boghog (talk) 21:39, 8 May 2015 (UTC)
- Your past and future efforts are hugely appreciated here! Formerly 98 talk|contribs|COI Statement 21:42, 8 May 2015 (UTC)
- Please, do not have the template filler subset the authors. If an article's convention only wants 3 shown, that should be done using display-authors=3. LeadSongDog come howl! 23:30, 8 May 2015 (UTC)
- Thanks to Boghog and Trappist the monk for this change! (At the risk of being greedy... presumably Citoid should generate wikimarkup that's similar or identical to what the RefToolbar generates.)
- I would agree with the above, annoying as it is to sometimes run into a lengthy author list in wikitext. Truncating the author list and thus dropping the senior authors would dilute the value of the metadata we're trying to generate. Opabinia regalis (talk) 00:09, 9 May 2015 (UTC)
- Please, do not have the template filler subset the authors. If an article's convention only wants 3 shown, that should be done using display-authors=3. LeadSongDog come howl! 23:30, 8 May 2015 (UTC)
- Your past and future efforts are hugely appreciated here! Formerly 98 talk|contribs|COI Statement 21:42, 8 May 2015 (UTC)
- I will try my best keeping Dberri online. The only reason it went off-line is that Dberri no longer had time to support it. Boghog (talk) 21:39, 8 May 2015 (UTC)
- Being a stylistic pig, I have no strong opinions about any of this except to request that you please don't take Dberri offline again. I'm too stupid to learn any other way of doing references. thanks. Formerly 98 talk|contribs|COI Statement 21:33, 8 May 2015 (UTC)
- thanks for everything, Boghog ... you're a gem. Now, back to All About Me! And the work needed on our medical FAs and with Wikipedia:Unreviewed featured articles/sandbox. I can hold off on evaluation of medical FAs, but once everything is in place, can we then go through the FAs to determine which have issues with inconsistent citations, and how to fix them (that is, if we need to make any global changes, like author to vauthor)? Bst, SandyGeorgia (Talk) 21:44, 8 May 2015 (UTC)
- @SandyGeorgia: There was a bug in the Wikipedia template filling tool which caused "et al." not to be output regardless of whether the checkbox was checked or not. This has now been fixed so that "et al." can once again be toggled on or off (compare on with off). Since most editors seem to favor full author lists for non-FA articles, I have changed the default output to not use "et al.". To get "et al.", you need to check the "Use et al. for author list" box. Please note that you can save a bookmarked link to the tool where this box is automatically checked. I hope this is OK. Please also note that the "et al." is currently incompatible with {{vcite2 journal}} but it will be compatible with the new
|vauthors=parameter in the standard {{cite journal}} template once the sandbox changes go live. We can also have a bot- identify Diberri style citations and replace
|author=with|vauthors=and remove|display-authors=etalif present and - replace {{vcite2 journal}} with {{cite journal}} since the updated {{cite journal}} template will support
|vauthors=.
- identify Diberri style citations and replace
- Finally the citation tool will be updated to output {{cite journal}} /
|vauthors=instead of {{vcite2 journal}}. Boghog (talk) 12:11, 10 May 2015 (UTC)- Thanks, Boghog. I vaguely follow all of this, but fair warning-- don't expect it to stick, because I find all of this template mumbo-jumbo so gummed up and necessary and it doesn't seem to stay in brain (in spite of your patient explanations). Kind of like the spelling of occassion and embarrass, which I can never remember correctly. (See the confusion about the templates still in the discussion with JMWt on my talk page.) So, when everything is good to go, if you ping me, we can start a new discussion here to figure out what we need to do to get consistent citations within our FAs (and not all of them use the same style). Thank you again for everything! SandyGeorgia (Talk) 15:48, 12 May 2015 (UTC)
- Thank you, Boghog, for putting the default to not have the template filler substitute
, et al.for the remaining vauthors. That is a job which really should be done by the template code, not the filler. Leaving it as an option is largely harmless, as editors will continue to make their own choices. Was there an agreement somewhere on reintroducing italics for et al.? I don't particularly care, but I thought the reverse was the case. As seen at MOS:Abbreviations, et al. is treated as an English loanword, so not italicized. WP:MOSMED does show the italics when referring to the ICMJE Uniform Requirements, but looking at those requirements it is clear that they do not call for italics either. (I suppose that means a correction to MOSMED is called for, to bring WPMED in line with the rest of WP and the ICMJE.) LeadSongDog come howl! 20:55, 12 May 2015 (UTC)- @LeadSongDog: Thanks for reminding me about the italics. It turns out that even if italics is specified, it is still rendered as plain text. For example:
- {{cite journal/new | vauthors = Choi J, Oh S, Lee D, ''et al.'' | title = Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice | journal = PLoS ONE | volume = 4 | issue = 11 | pages = e8011 | year = 2009 | pmid = 19956688 | pmc = 2776980 | doi = 10.1371/journal.pone.0008011 |doi-access=free}} renders as:
- Choi J, Oh S, Lee D, et al. (2009). "Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice". PLoS ONE. 4 (11): e8011. doi:10.1371/journal.pone.000801. PMC 2776980. PMID 19956688.
- Seeing how italics wiki markup is ignored, I will modify the template tool to remove it. One remaining issue is that according to the ICMJE requirements, a comma should be inserted between the last displayed name and "et al." in the rendered citation. But that is an issue with the {{cite journal}} template and not the template filling tool. Boghog (talk) 04:10, 13 May 2015 (UTC)
- @LeadSongDog: Thanks for reminding me about the italics. It turns out that even if italics is specified, it is still rendered as plain text. For example:
- Thank you, Boghog, for putting the default to not have the template filler substitute
- Thanks, Boghog. I vaguely follow all of this, but fair warning-- don't expect it to stick, because I find all of this template mumbo-jumbo so gummed up and necessary and it doesn't seem to stay in brain (in spite of your patient explanations). Kind of like the spelling of occassion and embarrass, which I can never remember correctly. (See the confusion about the templates still in the discussion with JMWt on my talk page.) So, when everything is good to go, if you ping me, we can start a new discussion here to figure out what we need to do to get consistent citations within our FAs (and not all of them use the same style). Thank you again for everything! SandyGeorgia (Talk) 15:48, 12 May 2015 (UTC)
- @SandyGeorgia: There was a bug in the Wikipedia template filling tool which caused "et al." not to be output regardless of whether the checkbox was checked or not. This has now been fixed so that "et al." can once again be toggled on or off (compare on with off). Since most editors seem to favor full author lists for non-FA articles, I have changed the default output to not use "et al.". To get "et al.", you need to check the "Use et al. for author list" box. Please note that you can save a bookmarked link to the tool where this box is automatically checked. I hope this is OK. Please also note that the "et al." is currently incompatible with {{vcite2 journal}} but it will be compatible with the new
That's great, thank you, though the authors should still be input as
{{cite journal/new | vauthors = Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS |display-authors=3 | title = Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice | journal = PLoS ONE | volume = 4 | issue = 11 | pages = e8011 | year = 2009 | pmid = 19956688 | pmc = 2776980 | doi = 10.1371/journal.pone.0008011 |doi-access=free}} Which still renders as
- Choi J, Oh S, Lee D, et al. (2009). "Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice". PLoS ONE. 4 (11): e8011. doi:10.1371/journal.pone.0008011. PMC 2776980. PMID 19956688.
{{cite journal}}: CS1 maint: article number as page number (link)
LeadSongDog come howl! 04:59, 13 May 2015 (UTC)
- @LeadSongDog: I agree that it is better to include all the authors and this is now the default output of the tool. However for those that prefer as compact a citation as possible, the "et al." option does that. The new
|vauthors=supports "et al." in the author list and will produce clean, albeit truncated author metadata. Please keep in mind that the main justifications for the new|vauthors=parameter is to reduce parameter bloat and the reduce the size of the imbedded citation. Having to add another parameter, namely|display-authors=, partially defeats the purpose of|vauthors=. I have argued that if|vauthors=is invoked, then|display-authors=should automatically set to six (the ICMJE recommendation and the current {{vcite2 journal}} default). Boghog (talk) 08:53, 15 May 2015 (UTC)
- @LeadSongDog: I agree that it is better to include all the authors and this is now the default output of the tool. However for those that prefer as compact a citation as possible, the "et al." option does that. The new
- I've added the comma before ' et al' to the Module:Citation/CS1/sandbox. In any case, it's a normal rule of English grammar that a comma delineates an abbreviation in these circumstances. --RexxS (talk) 20:38, 13 May 2015 (UTC)
- And sadly, I'm now in an edit war with the owner who wants to keep what we've done "historically". Oh well. --RexxS (talk) 22:05, 13 May 2015 (UTC)
Epigenetics of Human Herpesvirus Latency

This article was apparently created as part of a project at UT-Austin (see bottom of page). It certainly appears that it could use some TLC. Everymorning talk 02:20, 13 May 2015 (UTC)
- will look (I checked for copyvio User:CorenSearchBot/manual#Unprocessed requests--Ozzie10aaaa (talk) 13:34, 13 May 2015 (UTC)
- Another similar article has been created as a result of the same project: Epigenetics of Childhood Abuse and Trauma. Pinging SandyGeorgia who I know deals with this kind of stuff a lot. Everymorning talk 17:57, 14 May 2015 (UTC)
- WP:ENI is that-a-way, but if you all spend a bunch of time cleaning up poorly written and poorly sourced articles, it only makes it less likely that they can be sent back to user space. SandyGeorgia (Talk) 19:14, 14 May 2015 (UTC)
Ozzie10aaaa, could you please not alter your comments after others have already responded to them? It is my understanding (perhaps incorrect) that Corenbot can only compare to web content-- it does not have the ability to check books or journal articles that are not on the web. SandyGeorgia (Talk) 22:47, 14 May 2015 (UTC)
- the first part of your "comment" is not clear...the second part apparently you mean the bot found no "copyvio" ?...so I went here Wikipedia:Text Copyright Violations 101 1) Copyright Violation Detector will scan an article against the internet, excluding known mirrors (though not less common ones), which may be helpful in determining the point of origin of suspect text.2) Madman Bot/manual replaces Coren Search Bot/manual (offline since 31 Dec 2011) to compare an article against the internet; follow the instructions at the link...these are the two I used , the first one did not work properly, so I used the other..thank you--Ozzie10aaaa (talk) 23:03, 14 May 2015 (UTC)
Articles like this should be kept as the epigenetic mechanisms of disease processes is a very notable area of emerging research, especially in the case of neuroepigenetics. I feel it prudent to note that articles on disease epigenetics are virtually no different than what I've written in FOSB, which, while technically an article on a gene/protein, almost exclusively contains content that covers the transcriptional/epigenetic mechanisms of addiction; if I revised the lead, it could just as well be retitled "Transcriptional and epigenetic mechanisms of addiction".
It's also worth noting that these articles are just as relevant to WP:MCB + WP:Genetics and their guidelines (e.g., MOS:MCB) as they are to WP:MED and MOS:MED. Seppi333 (Insert 2¢) 00:49, 15 May 2015 (UTC)
- I agree--Ozzie10aaaa (talk) 12:11, 15 May 2015 (UTC)
Nutrition and pregnancy
This article is completely outside my area of expertise or interest and needs eyes. It was always rather problematic, but is getting a lot of attention recently from a new editor and it's looking more and more like a "How-to" guide as well as containing blacklisted links as "sources" (added by previous editors). Voceditenore (talk) 06:40, 13 May 2015 (UTC)
- will look--Ozzie10aaaa (talk) 10:55, 13 May 2015 (UTC)
- This has such a Western/wealthy industrialized country bias. It would be interesting to re-write it from the perspective of a poor person in a developing country (i.e., what's necessary, not what's nice). WhatamIdoing (talk) 18:00, 13 May 2015 (UTC)
- yes your correct--Ozzie10aaaa (talk) 12:12, 15 May 2015 (UTC)
- This has such a Western/wealthy industrialized country bias. It would be interesting to re-write it from the perspective of a poor person in a developing country (i.e., what's necessary, not what's nice). WhatamIdoing (talk) 18:00, 13 May 2015 (UTC)
WHO best practices for naming of new human infectious diseases
Only directly regards new infectious diseases, but the reasoning here may be of some broader interest perhaps. 86.134.202.206 (talk) 18:21, 9 May 2015 (UTC)
- good information...WHO, in consultation and collaboration with the World Organisation for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO), has identified best practices for the naming of new human diseases, with the aim to minimize unnecessary negative impact of disease names on trade, travel, tourism or animal welfare, and avoid causing offence to any cultural, social, national, regional, professional or ethnic groups.--Ozzie10aaaa (talk) 21:37, 9 May 2015 (UTC)
- Which is all very fine, I'm sure, but "unique" doesn't seem to be among the criteria. How any "Acute Respiratory Syndromes" do you think we'll end up with? WhatamIdoing (talk) 21:45, 12 May 2015 (UTC)
- that needs an objective answer/result --Ozzie10aaaa (talk) 12:27, 15 May 2015 (UTC)
- Which is all very fine, I'm sure, but "unique" doesn't seem to be among the criteria. How any "Acute Respiratory Syndromes" do you think we'll end up with? WhatamIdoing (talk) 21:45, 12 May 2015 (UTC)
MEDRS issue
The lead section of the article Health effects of tobacco currently references this paper in the NEJM. I am concerned that it does not meet MEDRS. The abstract says "We pooled data from five contemporary U.S. cohort studies..." so it might be a secondary source. Thoughts? Everymorning talk 15:31, 9 May 2015 (UTC)
- that is PMID 25671255. fwiw, neither pubmed nor medline classifies it as a review. Jytdog (talk) 16:26, 9 May 2015 (UTC)
- meta-analysis?...a quantitative statistical analysis of several separate but similar experiments or studies in order to test the pooled data for statistical significance--Ozzie10aaaa (talk) 17:05, 9 May 2015 (UTC)
- It is the combination of data from 5 other studies. It is okayish. Have reworded so text we contain is supported. Have removed popular press. And have moved out of the lead. Doc James (talk · contribs · email) 18:48, 9 May 2015 (UTC)
- (edit conflict)Just a couple of rapid thoughts...
- * The primary [observational] studies from which the data were drawn seem to have been chosen for reasons of convenience (no systematic review).
- * Not every pooled analysis is a meta-analysis .
- So, even if MEDRS considers this sort of analysis, in principle, to be a secondary source, imo reasonable advice might be - as always - to treat the source with care. (Note: I see DocJames has already trimmed the statement, together with a supporting non-MEDRS from the NYT. The page seems to have more general MEDRS issues.) 86.134.202.206 (talk) 18:59, 9 May 2015 (UTC)
- That is why I said okayish. I agree it does not appear to be a secondary source but may be one of those rare primary sources that is okayish.Doc James (talk · contribs · email) 19:02, 9 May 2015 (UTC)
- Agree. Fwiw, I think it may technically count as a secondary source in MEDRS parlance, given that it is a secondary analysis of primary sources. 86.134.202.206 (talk) 19:05, 9 May 2015 (UTC)
- I'm fairly certain that it's a secondary source, but it shows that not all secondary sources are equal. This is not a review but an analysis of pooled data from multiple primary sources with no stated selection criteria (other than "contemporary" and "US"). It aims to test a hypothesis (whether more than the 21 already-identified diseases may be attributable to smoking) and reaches a positive, if cautious, conclusion. If you think about it, the conclusions of this secondary source warrant no more weight than a single primary source with a similar sample size to the pooled data here. The same advice should apply here: use cautiously; and don't use it contradict higher quality secondary sources (reviews, systematic analyses) if they exist. --RexxS (talk) 19:59, 9 May 2015 (UTC)
- fwiw, i would classify it as primary; the experimental substrate is just data, which is why it ~seems~ tricky to classify. it asks new questions of old data Jytdog (talk) 21:27, 9 May 2015 (UTC)
- (fwiw) ...SR/MA do ask *
new* questions of *old* data. 86.134.202.206 (talk) 08:57, 10 May 2015 (UTC)- they do--Ozzie10aaaa (talk) 15:04, 15 May 2015 (UTC)
- (fwiw) ...SR/MA do ask *
- fwiw, i would classify it as primary; the experimental substrate is just data, which is why it ~seems~ tricky to classify. it asks new questions of old data Jytdog (talk) 21:27, 9 May 2015 (UTC)
- I'm fairly certain that it's a secondary source, but it shows that not all secondary sources are equal. This is not a review but an analysis of pooled data from multiple primary sources with no stated selection criteria (other than "contemporary" and "US"). It aims to test a hypothesis (whether more than the 21 already-identified diseases may be attributable to smoking) and reaches a positive, if cautious, conclusion. If you think about it, the conclusions of this secondary source warrant no more weight than a single primary source with a similar sample size to the pooled data here. The same advice should apply here: use cautiously; and don't use it contradict higher quality secondary sources (reviews, systematic analyses) if they exist. --RexxS (talk) 19:59, 9 May 2015 (UTC)
- Agree. Fwiw, I think it may technically count as a secondary source in MEDRS parlance, given that it is a secondary analysis of primary sources. 86.134.202.206 (talk) 19:05, 9 May 2015 (UTC)
- That is why I said okayish. I agree it does not appear to be a secondary source but may be one of those rare primary sources that is okayish.Doc James (talk · contribs · email) 19:02, 9 May 2015 (UTC)
- meta-analysis?...a quantitative statistical analysis of several separate but similar experiments or studies in order to test the pooled data for statistical significance--Ozzie10aaaa (talk) 17:05, 9 May 2015 (UTC)
AN2728, a topical boron-containing medication under development
Has been submitted to Articles for Creation at Draft:AN2728. Notable? Acceptable in current form? The references include lots and lots of clinical trials, and the body text includes statements like "Therefore AN2728 overall is well tolerated and safe." Arthur goes shopping (talk) 11:33, 15 May 2015 (UTC)
- reference #1 is MEDRS compliant...however #2-#8 are non-compliant (due to not either being reviews are being dated)...as for notability , probably this is an affirmative indication.--Ozzie10aaaa (talk) 12:03, 15 May 2015 (UTC)
- Thanks, I have accepted it and put a medref template at the top of it. Jytdog has pruned some problematic material and offered more advice on its talk page. Judging by earlier talk page material, it seens to have been created as part of a course, perhaps at Northeastern University. Looks likely the course ended in late April and left various things lying around, such as User:Iandoxsee/sandbox and User:Hbialic/Gelatin microparticle.
- It may be a problematic interaction between educational courses and the articles for creation process, that articles for creation reviewers will tend to avoid medical submissions because of a lack of knowledge and an abundance of caution, with the result that by the time the submissions eventually get declined or accepted ... can be about a month or so ... the course has ended and the student is no longer around to act on any feedback. Arthur goes shopping (talk) 12:21, 15 May 2015 (UTC)
- i went ahead and worked it over. it is a stub. PDE4B apparently needs updating for anybody who likes working on proteins and what they do. thanks for bringing this here Arthur goes shopping Jytdog (talk) 12:56, 15 May 2015 (UTC)
- will look--Ozzie10aaaa (talk) 15:23, 15 May 2015 (UTC)
- i went ahead and worked it over. it is a stub. PDE4B apparently needs updating for anybody who likes working on proteins and what they do. thanks for bringing this here Arthur goes shopping Jytdog (talk) 12:56, 15 May 2015 (UTC)
Can a source be secondary for some things and primary for others?
(note - section header was formerly " RFC - Does a Clinical Trial Qualify as a Primary Source" and i just changed it. This is not an RfC, but rather an informal effort to get community input, and the question reflected a garbled edit note Jytdog (talk) 01:45, 16 May 2015 (UTC)) )
This RFC specifically relates to a discussion @Formerly 98: and I were having about a revert he made. My opinion is the underlying source is a secondary in nature, even the conclusions about the clinical trials because WP:MEDRS states clinical trials are primary sources. I'll allow him to respond to represent his own opinion or refer you to the commentary in his revert which says "While the overview of safety assessment is secondary research, the conclusion that "most men who would be prescribed finasteride were excluded from trials" is from a primary, single site research study and fails MEDRS". The text removed appears in the conclusion of the abstract for the meta-study. Any objective feedback is appreciated. Thanks. Doors22 (talk) 10:51, 15 May 2015 (UTC)
- Where is this RfC being conducted? AndyTheGrump (talk) 10:55, 15 May 2015 (UTC)
- What is the question? Blue Rasberry (talk) 11:19, 15 May 2015 (UTC)
- some questions need to be answered first (see above) though the topic is interesting--Ozzie10aaaa (talk) 12:05, 15 May 2015 (UTC)
I'm not sure this is a formal RFC (I don't think either Doors or myself have every learned how to do that), but it would be helpful to have outside input over on the article Talk page.
The study in question is here. As I have understood it (Doors may have a different view), the study had two parts. They reviewed the historical trials of finasteride and evaluated whether the processes for collected adverse event data were adequate, and concluded that they were not. They also compared the trial eligibility criteria (inclusion and exclusion criteria) to the characteristics of a group of men recently prescribed finasteride for hair loss at their local medical center (I think this is what they did, the protocol is not clearly explained). Based on the latter data they concluded that "most men prescribed finasteride for hair loss were from groups not represented in the trials".
I have argued that the meta analysis of the trials is secondary research, but the study comparing the people prescribed finasteride at the local medical center to the exclusion criteria is primary. As I undertand it, Doors feels the entire study is secondary. This is the issue we need help with. My detailed arguments, along with those of Doors, are on the article talk page here.
Doors and I have a long history of conflict, and we are trying to get off on a better footing, so any input would be real helpful. Formerly 98 talk|contribs|COI Statement 12:22, 15 May 2015 (UTC)
- IMO...I have argued that the meta analysis of the trials is secondary research, but the study comparing the people prescribed finasteride at the local medical center to the exclusion criteria is primary...this statement is correct --Ozzie10aaaa (talk) 12:31, 15 May 2015 (UTC)
- just so everybody is aware, this study was funded in part by Post-Finasteride Syndrome Foundation. And it found a suggestion of systematic underdetection of sexual adverse effects in clinical trials. So it is important to the people who have been very concerned about that. It is a good thing to discuss this in the community to keep it from getting personalized on the Talk page. Jytdog (talk) 13:02, 15 May 2015 (UTC)
- "What is the question?" The title of this subsection seems to imply that the question is: "Does a clinical trial qualify as a primary source?" The answer to that is: yes, a paper that specifically describes the method, findings and conclusion of a clinical trial is indeed a primary source.
- The contentious statement is: "Moreover, the trials submitted to the FDA for approval for hairloss excluded most men who would normally be prescribed finasteride for androgenic alopecia." Two references are provided for this statement: Belknap and Moore. Belknap's paper is a meta-analysis. Moore's paper is a review of Belknap's paper.
- Belknap states: "In a cohort of men prescribed finasteride for routine treatment of AGA, most would have been excluded from the pivotal studies that supported US Food and Drug Administration approval for AGA." Therefore the contentious statement is supported by Belknap.
- To clarify: Belknap's paper is a secondary source and is suitable to support the statement in Wikipedia's article. Axl ¤ [Talk] 14:29, 15 May 2015 (UTC)
- Ok, I'm supposed to be listening to the community here and not arguing, but strictly speaking...
- You stated "Belknap's paper is a secondary reference" I've stated above that I think it is primary for the contentious statement, because the conclusion relies on previously unpublished original research. Could you explain your reasoning in a way that responds to what I said?
- The Moore paper is technically not a review, but an editorial. Can the editorial be considered a secondary source?
- Thanks Formerly 98 talk|contribs|COI Statement 15:51, 15 May 2015 (UTC)
- Ok, I'm supposed to be listening to the community here and not arguing, but strictly speaking...
- I have not commented on this issue yet. The statement quoted by Axl (and lightly paraphrased in the article, which Formerly removed) is from the abstract of the Belknap paper (PMID 25830296). If you read the paper and see what they did, here is part of the Methods section:
To assess generalizability, we evaluated eligibility for the 3 manufacturer-sponsored trials26,27,32 referenced in the Clinical Studies section of the full prescribing information for finasteride, 1 mg, using as our data source the Northwestern University Enterprise Data Warehouse, a clinical data repository of ambulatory and hospitalized patients, providing laboratory data and diagnosis codes from 1992 through 2013 and comprehensive electronic medical record data from January 2001 through September 2013. We applied a 1.25-mg dose threshold because tablet splitting of the 5-mg dose was widely used as a cost-saving measure. We identified all International Classification of Diseases, Ninth Revision (ICD-9) codes for the cohort of men prescribed finasteride, 1.25 mg/d or less, in the clinical data repository and identified 345 exclusionary ICD-9 codes based on the exclusion criteria for the 3 trials26,27,32 referenced in the full prescribing information for men younger than 42 years. Principal exclusion criteria included significant abnormalities on screening physical examination or laboratory evaluation.26,27
So, that part of their conclusions is original research reported in the Belknap paper. The Belknap paper also has sections performing a review of the clinical trial literature, but that part in particular is original research reported in that paper, and the Belnap paper is PRIMARY for that. (i believe that this is what Formerly was trying to communicate in his edit note, which i have found garbled nonsensish until now) The accompanying editorial (Moore PMID 25831198) is an editorial, not a review. This is indeed the kind of the thing that we wait for a review to integrate. Do folks here see that, or do you disagree? Please do weigh in. Thanks
I also want to say that I think that both Belknap and Moore make it clear that we don't have good data showing whether there are or are not long term effects (not correlation) in some small amount of men - both emphasize the difficulty of getting that kind of data, ever. They could be both used to make a statement like that. Jytdog (talk) 01:43, 16 May 2015 (UTC)
Wikipedia a tool for epidemiology?
I found this interesting article: Generous, N.; Fairchild, G.; Deshpande, A.; Del Valle, S. Y.; Priedhorsky, R. (2014). "Forecasting diseases using Wikipedia". PLOS Computational Biology. 10 (11). Medicalxpress.com: e1003892. doi:10.1371/journal.pcbi.1003892. PMC 4231164. PMID 25392913. Retrieved 2015-05-16.{{cite journal}}: CS1 maint: article number as page number (link) -- Roger (Dodger67) (talk) 12:12, 16 May 2015 (UTC)
- interesting... We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges...--Ozzie10aaaa (talk) 13:28, 16 May 2015 (UTC)
Query misuse of "main template"
Wondering if others could comment here Talk:Alcoholism#Main links Doc James (talk · contribs · email) 13:20, 16 May 2015 (UTC)
- give opinion (i gave mine)--Ozzie10aaaa (talk) 13:53, 16 May 2015 (UTC)
my first new article - Botanical drug
came across Sinecatechins today while doing something else and realized we had nothing on the drug class. Jytdog (talk) 01:13, 3 May 2015 (UTC)
- very good article--Ozzie10aaaa (talk) 10:49, 3 May 2015 (UTC)
- WP:DYK! Please! Let's have an important subject of interest to the whole world in the list. WhatamIdoing (talk) 16:36, 3 May 2015 (UTC)
- I generally don't do any of that GA/FA/DYK/ITN stuff but if somebody else wants to DYK it, fine by me. i posted it here b/c i am a little proud to have made my first article and also just to have it looked over for acceptability and anything bad fixed. no news is good news in that regard. Jytdog (talk) 17:36, 3 May 2015 (UTC)
- you should be very proud (ive read thru it twice and this ref once)--Ozzie10aaaa (talk) 18:35, 3 May 2015 (UTC)
- I generally don't do any of that GA/FA/DYK/ITN stuff but if somebody else wants to DYK it, fine by me. i posted it here b/c i am a little proud to have made my first article and also just to have it looked over for acceptability and anything bad fixed. no news is good news in that regard. Jytdog (talk) 17:36, 3 May 2015 (UTC)
- WP:DYK! Please! Let's have an important subject of interest to the whole world in the list. WhatamIdoing (talk) 16:36, 3 May 2015 (UTC)
by the way, i am a bit stymied by what do with the relationship among Epigallocatechin gallate, green tea extract (which is horrible) and Sinecatechins... Jytdog (talk) 17:38, 3 May 2015 (UTC)
- maybe ? Mechanism of Action the exact mechanism of action of sinecatechins ointment is unknown, although epigallocatechin gallate (a major component of both green tea and sinecatechins ointment) has been shown to suppress the growth of... first book on top, same reference --Ozzie10aaaa (talk) 18:41, 3 May 2015 (UTC)
- Nice! I just did a very inadequate amount of cleanup of that awful green tea extract article. DYK is a maze of twisty templates all alike, but it'd be nice to see something like this on the main page. Opabinia regalis (talk) 20:41, 3 May 2015 (UTC)
Nicely done! What interesting to me is that people measure antioxidant potential of these polyphenols and think more is better. But another way of saying that these compounds are antioxidants is to say they are easily oxidized, and the oxidation products they form are not necessarily more innocuous than the ones they prevent. Epigallocatechin is not only cytotoxic, our article lists it as a carcinogen. For all the articles in the literature discussing its enzyme inhibition properties at high micromolar concentrations, I'd guess that it's oxidation product is a good old fashioned DNA alkylator. The tea drinking countries of the world also have the highest rates of liver cancer, though HBV is an obvious confounder, Formerly 98 talk|contribs|COI Statement 23:39, 3 May 2015 (UTC)
- Antioxidants cure everything! Also, if you feel bad, you need more oxygen in your cells, and more antioxidants to soak up the oxygen! I had a friend who ran an ozone generator in her home because she actually thought it was healthful. (It was cheap enough that it probably didn't work.) There are a lot of myths out there.
- I've sent the new article to DYK. One of the lovely things about DYK is that the cooperation of the original author is not required. If you're interested, then put Template:Did you know nominations/Botanical drug on your watchlist (and help out: medicine-related DYKs are rare, but good ones are even rarer). WhatamIdoing (talk) 23:55, 3 May 2015 (UTC)
- Although oxidation reactions are crucial for life, they can also be damaging; plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, vitamin A, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Insufficient levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells. Oxidative stress is damage to cell structure and cell function by overly reactive oxygen-containing molecules and chronic excessive inflammation. Oxidative stress seems to play a significant role in many human diseases, including cancers. The use of antioxidants in pharmacology is intensively studied, particularly as treatments for stroke and neurodegenerative diseases. For these reasons, oxidative stress can be considered to be both the cause and the consequence of some diseasesAntioxidant...i agree--Ozzie10aaaa (talk) 13:25, 6 May 2015 (UTC)
- ozzie, the antioxidant hypothesis for neuroprotection or cancer treatment has been around for ages. every single clinical trial of an antioxidant has failed (with one exception that i know of) - the most dramatic being the SELECT trial. every one. the only exception to that, that i am aware of, is Biogen's recent FDA approval on Dimethyl fumarate for MS. that compound is ~thought~ to work by activating NRF2. and yes per Formerly people are realizing (especially following the SELECT trial, that oxidation serves some useful purposes in maintaining homeostasis and shutting it down is not necessarily a great thing Jytdog (talk) 13:35, 6 May 2015 (UTC)
- review article (which in its text indicates the findings in regards to antioxidants)....Ginseng and ginsenosides have vasorelaxation
- antioxidative,anti-inflammatory, and anticancer properties. In addition, ginsenosideshave also shown to have an effect on the nervous system [14].Moreover, ginseng has shown more benefit in individuals with diseases compared with healthy individuals [15e17]. In addition, a previous study supported its growing evidence for its indications in CVDs [12]. P. ginseng roots and extracts have been traditionally used by Koreans to renew the body and mind, and improve physical condition.Ginseng is also widely used in individuals with cardiovascular risk factors such as hypertension and hypercholesterolemia--Ozzie10aaaa (talk) 18:47, 11 May 2015 (UTC)
- I think the key point here is to avoid oversimplification. Yes, the body has and needs systems for preventing uncontrolled oxidation processes, and it uses anti-oxidants such as glutathione, vitamin E and vitamin C for this purpose. But:
- All anti-oxidants can be considered sacrificial substrates - e.g. they are easily oxidized substances that protect more valuable biochemicals by soaking up the pool of available oxidants
- Endogenous ("Natural"?) anti-oxidants such as glutathione, vitamin C, and vitamin D also have the property that they are oxidized to stable substances. Glutathione forms a stable dimer; vitamin C forms dehydroascorbic acid, and so on.
- But not all "antioxidants" (easily oxidized compounds) will have this latter property. Some will be oxidized to reactive substances that can alkylate DNA and do other bad things. Acetominophen is a classic example. It undergoes oxidation in the liver to form a quinone like compound that alkylates proteins and possibly DNA. Overdose causes hepatic failure.
- So for the most part, it is hard to look at the structure of a "dietary phenol" and say much other than that is it easily oxidized. Whether it will exert a protective or toxic effect due to its sacrificial oxidation depends on the strucutre of the product that is produced by that oxidation.
- Much of what is in the literature is bullshit, because it broadly hypothesizes beneficial systemic effects for oral intake of easily oxidized compounds ("antioxidants"). However, nothing taken by mouth sees systemic circulation until after it passes into the portal vein and through the liver. The liver is the most highly oxidizing environment in the body, and most of these easily oxidized substances never come out the other side. The oxidation process that occurs in the liver will in some specific cases produce electrophiles that can cause liver damage.
- I think the key point here is to avoid oversimplification. Yes, the body has and needs systems for preventing uncontrolled oxidation processes, and it uses anti-oxidants such as glutathione, vitamin E and vitamin C for this purpose. But:
- Formerly 98 talk|contribs|COI Statement 13:52, 6 May 2015 (UTC)
- ozzie, the antioxidant hypothesis for neuroprotection or cancer treatment has been around for ages. every single clinical trial of an antioxidant has failed (with one exception that i know of) - the most dramatic being the SELECT trial. every one. the only exception to that, that i am aware of, is Biogen's recent FDA approval on Dimethyl fumarate for MS. that compound is ~thought~ to work by activating NRF2. and yes per Formerly people are realizing (especially following the SELECT trial, that oxidation serves some useful purposes in maintaining homeostasis and shutting it down is not necessarily a great thing Jytdog (talk) 13:35, 6 May 2015 (UTC)
- Although oxidation reactions are crucial for life, they can also be damaging; plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, vitamin A, and vitamin E as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Insufficient levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress and may damage or kill cells. Oxidative stress is damage to cell structure and cell function by overly reactive oxygen-containing molecules and chronic excessive inflammation. Oxidative stress seems to play a significant role in many human diseases, including cancers. The use of antioxidants in pharmacology is intensively studied, particularly as treatments for stroke and neurodegenerative diseases. For these reasons, oxidative stress can be considered to be both the cause and the consequence of some diseasesAntioxidant...i agree--Ozzie10aaaa (talk) 13:25, 6 May 2015 (UTC)
Botanical drug was on the main page a few hours ago. See Wikipedia:Recent additions#15 May 2015 for the entry. WhatamIdoing (talk) 16:21, 15 May 2015 (UTC)
- congratulation!--Ozzie10aaaa (talk) 17:47, 16 May 2015 (UTC)
Brainwave entrainment; Audio-visual entrainment
some groovy fun (more neuroscience than medicine) but needs some work, as do the daughter articles Binaural beats and Monaural beats. poor Brainwave entrainment has been tagged for help since 2008. oy. Jytdog (talk) 15:43, 12 May 2015 (UTC)
- will look (Monaural beats )--Ozzie10aaaa (talk) 17:01, 12 May 2015 (UTC)
- This is a topic where there is a bunch of fascinating science that the article ought to cover, but the current version is almost entirely devoted to pseudoscience, and the people who have been interested in the article have cared a lot more about the pseudoscience than the science. Up to now I haven't had the courage to try to do anything with it. Looie496 (talk) 13:30, 13 May 2015 (UTC)
- that is the reason, I chose to edit one of the "daughter articles" instead--Ozzie10aaaa (talk) 22:07, 16 May 2015 (UTC)
- This is a topic where there is a bunch of fascinating science that the article ought to cover, but the current version is almost entirely devoted to pseudoscience, and the people who have been interested in the article have cared a lot more about the pseudoscience than the science. Up to now I haven't had the courage to try to do anything with it. Looie496 (talk) 13:30, 13 May 2015 (UTC)
Authority control
This garbage was just installed at tic disorder; can anyone tell me what it is and what good it does our readers or anyone else? SandyGeorgia (Talk) 17:11, 16 May 2015 (UTC)
- apparently what it is --Ozzie10aaaa (talk) 17:38, 16 May 2015 (UTC)
- that is every bit as intelligible as the gibberish inserted into the article via the link above. my question stands. SandyGeorgia (Talk) 17:50, 16 May 2015 (UTC)
- sandy you remind me so much of the heroine of the terminator movies. You will not accept our inevitable domination by our machine overlords! :) Jytdog (talk) 18:40, 16 May 2015 (UTC)
- No, Jytdog, you've got it all wrong. Remember Alien (film)? And Sigourney Weaver battling that creature? I'm the alien :) SandyGeorgia (Talk) 23:53, 16 May 2015 (UTC)
- oh you are always surprising! i thought of you as protecting editors (the little girl) from the alien get away from her.... but wow - editors as the wild, dangerous alien encroached upon by smothering "civilization". crazy and wonderful 19th century german romanticism. i love this place. Jytdog (talk) 00:00, 17 May 2015 (UTC)
- No, Jytdog, you've got it all wrong. Remember Alien (film)? And Sigourney Weaver battling that creature? I'm the alien :) SandyGeorgia (Talk) 23:53, 16 May 2015 (UTC)
- sandy you remind me so much of the heroine of the terminator movies. You will not accept our inevitable domination by our machine overlords! :) Jytdog (talk) 18:40, 16 May 2015 (UTC)
- that is every bit as intelligible as the gibberish inserted into the article via the link above. my question stands. SandyGeorgia (Talk) 17:50, 16 May 2015 (UTC)
An authority control is a unique identifier that allows libraries throughout the world to identify a subject unambiguously. It is used by researchers and library catalogues to ensure that their searches are finding the precise topic required. To take an extreme example, if you have a look at the bottom of our article on Alexander Graham Bell, you'll see that there are around a dozen different identifiers for him, e.g. VIAF, LCCN, SUDOC, etc., many of which are language specific: LCCN (the Library of Congress Control Number) is English (American to be precise); SUDOC (Système universitaire de documentation) is French; NDL (National Diet Library) is Japanese; and so on. It is unfortunate that Tic disorder only has the NDL identifier recorded on Wikidata so far, so all you see when following the link is Japanese. I'm sure it's helpful for any Japanese researchers or librarians who are browsing our article - which appears to be a little better developed than the corresponding article on the Japanese wiki. If anyone knows any English authority controls for Tic disorder, I'd gladly update Wikidata with them - or show you how to do that if preferred. Hope that helps. --RexxS (talk) 19:44, 16 May 2015 (UTC)
- thank you RexxS--Ozzie10aaaa (talk) 20:19, 16 May 2015 (UTC)
- Update: I've added the GND (Gemeinsame Normdatei) identifier that I was able to find, but that's in German. Cheers --RexxS (talk) 20:06, 16 May 2015 (UTC)
- Thanks, RexxS. I'm not sure I'm any smarter now than I was this morning, but I'm glad to know it means something to someone somewhere. SandyGeorgia (Talk) 23:54, 16 May 2015 (UTC)
- Update: I've added the GND (Gemeinsame Normdatei) identifier that I was able to find, but that's in German. Cheers --RexxS (talk) 20:06, 16 May 2015 (UTC)
Note that Template:Authority control is really intended (read tested) for people. For medical subjects use http://id.loc.gov/ (think http://id.loc.gov/authorities/subjects/sh85135241 ) or the (beta) http://id.nlm.nih.gov/mesh/ . Stuartyeates (talk) 21:30, 17 May 2015 (UTC)
Low THC cannabis (formerly Charlotte's web)
I've made some extensive edits to the Low THC cannabis article that I suspect will be controversial. Input from other editors is highly welcome. Formerly 98 talk|contribs|COI Statement 23:55, 15 May 2015 (UTC)
- edits seem appropriate--Ozzie10aaaa (talk) 09:56, 16 May 2015 (UTC)
- 100% of them have been reverted. Formerly 98 talk|contribs|COI Statement 10:34, 16 May 2015 (UTC)
- Yes, there was no consensus for such massive removal of properly sourced content, or for changing the title to a different subject. JzG (Guy) was correct to revert back per BRD. One man's attempt to hijack an article, with the intention of stripping it of most of its content, and then to create an article on a different subject, is very bad form. -- BullRangifer (talk) 00:39, 18 May 2015 (UTC)
- Oh, good, misinformation here too? No, BR, what JzG did was basically editwar with you against consensus, because there are PLENTY of us who disagree with everything about that article and support the changes made by Formerly98. JzG exercised a supervote, as if an admin has that in content issues. You and he also removed my advert tag, and the article is STILL an inappropriate advert (unless Formerly rewrote it after I unwatched).
Would you please do me a favor? I unwatched that article because what you have done there-- tossing MEDRS out the window to write a promotional advocacy piece, which undermines MEDRS for ALL of our medical content heneceforth-- disgusts me more than anything I have ever seen in here. Would you please keep your discussion over there so I don't have to see it? Thank you, SandyGeorgia (Talk) 00:46, 18 May 2015 (UTC)
- Oh, good, misinformation here too? No, BR, what JzG did was basically editwar with you against consensus, because there are PLENTY of us who disagree with everything about that article and support the changes made by Formerly98. JzG exercised a supervote, as if an admin has that in content issues. You and he also removed my advert tag, and the article is STILL an inappropriate advert (unless Formerly rewrote it after I unwatched).
- Yes, there was no consensus for such massive removal of properly sourced content, or for changing the title to a different subject. JzG (Guy) was correct to revert back per BRD. One man's attempt to hijack an article, with the intention of stripping it of most of its content, and then to create an article on a different subject, is very bad form. -- BullRangifer (talk) 00:39, 18 May 2015 (UTC)
- 100% of them have been reverted. Formerly 98 talk|contribs|COI Statement 10:34, 16 May 2015 (UTC)
- This is the article that caused me to give up in here and take a very long wikibreak, and why I very rarely weigh in on the running disputes at ANI. It disgusts me when we have big fat long running disputes over (compared to the impact of an article like this) relatively benign fringe topics like acupuncture, while something as dangerously promotional and POV as this article is ignored en masse by WP:MED, in spite of now the fourth thread here.
Really, we need to clean our own house before we throw stones. SandyGeorgia (Talk) 14:28, 16 May 2015 (UTC)
- This is the article that caused me to give up in here and take a very long wikibreak, and why I very rarely weigh in on the running disputes at ANI. It disgusts me when we have big fat long running disputes over (compared to the impact of an article like this) relatively benign fringe topics like acupuncture, while something as dangerously promotional and POV as this article is ignored en masse by WP:MED, in spite of now the fourth thread here.
- No, but I'd say that misinformation that is likely to prompt a reader to make an actual treatment decision is more worriesome than incorrect or incomplete information about the genetics of GERD. Above all else, we need to be sure we are doing no harm. Formerly 98 talk|contribs|COI Statement 21:05, 17 May 2015 (UTC)
Let's seek to understand this.... Reporting that homeopaths use homeopathy to treat all kinds of diseases, and some chiropractors claim to use spinal manipulation to cure cancer, MS, heart disease, deafness, and allergies, is not "disinformation", it is reporting what they claim to do. That is our job. Documentation of nonsense is not promotion of nonsense. We must report that, without promoting it in Wikipedia's voice as if it's actually a scientifically proven option. (That's the balancing act in all our alternative medicine articles.) You will note that those articles, and the CW article, make it clear that such claims are unproven and reports of healings are anecdotes. There is plenty of content which makes that clear. More research is needed. That's what everyone says, and that's what we report. We do it because RS say so.
Instead of making these vague aspersions here, try getting very specific at the article, instead of forum shopping here. I want to see the exact words which could be misunderstood. When that has been done at the article, I have made changes to meet those concerns.
The one thing I won't do is strip the body of that Corvette (CW) so you can hijack its chassis for the "chassis museum" article (Low THC cannabis) you want to write. Our Corvette (CW) would be gone, and it happens to have far more than enough independent notability to justify its existence as an article. Our notability policy won't disappear just to suit you in this case. I'm sticking by it. -- BullRangifer (talk) 00:39, 18 May 2015 (UTC)
- For anyone who wants to wade through walls of off-topic text and sad tugging at our heartstrings aiming at promoting changes in medical marijuana laws for children based on unproven anecdote and using breathless stories of little Charlotte and the poor marketers getting death threats on Facebook will find Talk:Charlotte's Web (cannabis) that-a way --------> (If they start at the top, and can get through all of that to read the whole page, they will find some very good posts about how we actually write on Wikipedia by Colin. Who is our best epilepsy content editor and the main architect of MEDRS. )
Would you mind keeping it over there? Much obliged, SandyGeorgia (Talk) 00:53, 18 May 2015 (UTC)

