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Input requested at Kombucha

Hi there, we're having some difficulty seeing eye to eye on a claim about deaths-by-Kombucha.

The source being used for the claim is from an American Cancer Society piece, where they reference this 20 year old case.

"No studies have been done on humans to support any of the claims made for Kombucha tea. There have, however, been reports of some serious complications associated with the tea. In April 1995, two women who had been consuming the tea daily for two months were hospitalized with severe acidosis--an abnormal increase of the acid levels in body fluids. Both had high levels of lactic acid upon hospitalization. One woman died of cardiac arrest two days after admission. The second woman’s heart also stopped, but she was stabilized and recovered. The mushrooms used by both women came from the same "parent" mushroom. While no direct link to Kombucha tea was proven in this case, the FDA has warned consumers to use caution when making and drinking the tea."

Alexbrn has summarized it thusly:

"Drinking kombucha has been linked, in rare cases, to serious side effects and deaths".

Since the ACS specifically says "no direct link", it seems "has been linked" is misleading. Any clarity on the application of MEDRS and how this is best summarized would be appreciated. Here is the related talk page section. petrarchan47คุ 07:13, 8 June 2015 (UTC)

This is a misrepresentation. I am not summarizing the quoted text but instead following the "Overview" of the ACS piece which states: "Available scientific evidence does not support claims that Kombucha tea promotes good health, prevents any ailments, or works to treat cancer or any other disease. Serious side effects and occasional deaths have been linked with drinking Kombucha tea." The "no direct link" wording used by the ACS is in respect of one case and is not an overall summary of the state of knowledge on this topic. Alexbrn (talk) 07:19, 8 June 2015 (UTC)
What is the evidence? There is no scientific evidence to support any of the claims made for Kombucha tea. There have been reports of some serious complications associated with the tea.3 In April 1995, two women who had been consuming the tea daily for two months, were hospitalized with severe acidosis--an abnormal increase in the acidity in the body fluids. Both had high levels of lactic acid upon hospitalization. One woman died of cardiac arrest two days after admission. The second woman also suffered a heart attack but was stabilized and eventually released. The mushrooms used by both women came from the same "parent" mushroom. While no direct link to Kombucha tea was proven in this case, the FDA has warned consumers to use caution when making and drinking the tea 4....i (have answered both here and at the link, since there is discussion at both places), this seems to indicated what your referring to petrarchan47 I happen to agree with you (BTW this source is non-MEDRS compliant, not too different from a 20 year old statement... for a compliant MEDRS source see below) --Ozzie10aaaa (talk) 10:48, 8 June 2015 (UTC)
(add) on the ability of KT to protect against a vast number of metabolic and infectious diseases, but very little scientific evidence is available that validates the beneficial effects of KT. The aim of this review is to give an overview of the recent studies in search of experimental confirmation of the numerous KT health-promoting aspects cited previously. Analysis of the literature data is carried out in correspondence to the recent concepts of health protection's requirements. Attention is given to the active compounds in KT, responsible for the particular effect, and to the mechanisms of their actions. It is shown that KT can efficiently act in health prophylaxis and recovery due to four main properties: detoxification, antioxidation, energizing potencies, and promotion of depressed immunity. The recent experimental studies on the consumption of KT suggest that it is suitable for prevention against broad-spectrum metabolic and infective disorders. This makes KT attractive as a fermented functional beverage for health prophylaxis. review 2014--Ozzie10aaaa (talk) 11:53, 8 June 2015 (UTC)
Are you seriously proposing we use happyherbalist.com to sink the view of the American Cancer Society!? Alexbrn (talk) 11:14, 8 June 2015 (UTC)
no...im looking for further information of this and have posted a review 2014 PubMed index as well--Ozzie10aaaa (talk) 11:21, 8 June 2015 (UTC)
Our article already cites that, alongside another 2014 review. Alexbrn (talk) 12:51, 8 June 2015 (UTC)
Since the ACS piece seems no longer to appear, and the site now apparently doesn't mention KT at all, I think we should drop that source. Johnbod (talk) 15:26, 8 June 2015 (UTC)
It was there yesterday. An amazing coincidence that the very time the site changes the source gets challenged! I wonder whether the ACS are doing a site reorg or if they've decided to drop this topic for good. Alexbrn (talk) 17:46, 8 June 2015 (UTC)
Weird conspiratorial meandering aside, the source was dead when I came across it on the 6th. petrarchan47คุ 18:19, 8 June 2015 (UTC)
Thanks for the responses! I've added sources that do not seem to support the death-by-Kombucha claim here, whilst overnight the claim in the article has lept from "linked" to "causes". petrarchan47คุ 19:59, 8 June 2015 (UTC)
After researching sources to confirm Wikipedia:Verifiable but not false, and in following MEDRS guidelines which tell us case reports regardless of whether they are in a scientific journal or popular media are below miniumum requirements as RS, there is no doubt the material should be removed. Core policy WP:V tells us extraordinary claims require extraordinary (multiple) sources, so inclusion of death and toxicity claims as causality fail on multiple counts. Put simply, the anecdotal material is noncompliant with PAGs. Considering the article is also subject to DS I don't think it is advisable to insist on keeping poorly sourced extraordinary claims in the article that are fundamentally noncompliant with core policy, WP:V. Also, the journal review indicates that the case reports involved a small number of individuals, there was no scientific evidence to confirm causality. It is believed the problems arose not from the inherent factors of kombucha but primarily through contamination or lead seepage from the ceramic containers during fermentation. If the journal review and common sense isn't convincing enough to justify removal of the anecdotal passages (extraordinary claims), then the dates should be considering the majority of the case reports date back to the 90s with only a few (rare cases) reported 6 or so years ago. Moreover, some of the books that were written citing those same case reports are not RS, two of which were cited for the death claims in the article and are factually inaccurate. At best, we could include highlights with intext attribution citing the conclusion of the 2014 review. --Atsme📞📧 17:44, 11 June 2015 (UTC)
That comment makes little sense. We should simply summarize good secondary sources, rather than misreading and inventing policy to try and swerve around them. Alexbrn (talk) 18:15, 11 June 2015 (UTC)
"After researching sources..."? Looks like WP:OR to me. And what's with the 'extraordinary claims'? There is nothing extraordinary in a claim that fermentation under uncontrolled conditions can produce toxic substances. AndyTheGrump (talk) 18:25, 11 June 2015 (UTC)

Doc James I know WP doesn't give medical advice but I find the condescension ad nauseum. Would you be so kind as to read my post regarding "verifiable but false" information as it relates to RS that do not pass MEDRS guidelines and explain how it applies to case reports? It will be very helpful particularly with regards to editing other articles, like atrazine, and the like. Thank you in advance. Atsme📞📧 19:54, 11 June 2015 (UTC)

Reading through a couple of comments:
  • I would disagree that 5 major newspapers are reliable sources when it comes to medical content. Sources / evidence are like school children. 5 first graders do not equal one 5 grade in ability.
  • I like the "true to presentation" bit.
  • I also like that extreme ideas require extreme sources. One would need amazing sources to support the idea that TMers can actually fly
Doc James (talk · contribs · email) 22:10, 11 June 2015 (UTC)
When we are dealing with major topics like diabetes, we never have to use less than idea sources and there are lots of ideal sources out there. When it comes to obscure topics like Kombucha there are few great sources and we must thus be careful and try to use the best available sources. Doc James (talk · contribs · email) 22:14, 11 June 2015 (UTC)
My response below isn't a response to you, Doc, just wanted to make that clear. petrarchan47คุ 03:43, 12 June 2015 (UTC)

When the American Cancer Society hosted a webpage citing a link to deaths in 1997, that source was considered the top quality source, and its contents copied to the Lede almost verbatim. However, when that source disappeared, similar sources were suddenly considered not ideal, and 2 obscure sources were used instead, one of them 10 years old.

The Mayo Clinic and the Swedish Medical Center, both on par with the ACS source, cover the adverse effects of Kombucha - neither mention death. They go into (rather encyclopedic) detail about the ways in which people have become sickened by drinking Kombucha, as well as contributing factors that may have played a role.

The Lede now says: "...and the drinking of kombucha has been linked to illness, and the death of at least one person."

The 2 blurbs that were found and used for the above say:

"Kombucha tea; a general cure-all; can cause acidosis and death" -- 2005
"Kombucha has been associated with illnesses and death. A tea made from Kombucha is said to be a tonic, but several people have been hospitalised and at least one woman died after taking this product"

Because of MEDRS, the first source is unusable. The second source is not a strong enough claim to add it, without more details, to the Lede in this fashion. IMO, the readers should know how very loose the "link" really is -- not because I am part of a Kombucha Cabal, but simply because the truth is what we're here for. Other sources that have covered this topic go into a bit of detail behind that various serious side effects that have been reported. When the entire story is told, the picture that emerges is very different from Wikipedia's entry.

Those supporting this single source and claims of deadly Kombucha need to reconcile why the Mayo Clinic and Swedish source don't mention death in their list of negative effects.

It is obvious that POV is playing a role in the sudden flip flop on what is considered the best source. If we can quote the ACS verbatim, we should be able to quote the Mayo clinic in exactly the same way. Suggesting a 10 year old source to counter this is not good form, not after all the haughty lectures I've received on MEDRS. The single book that cites a death is a fringe claim, and we can't give a platform to fringe claims without really going into what the majority of high quality sources say. But you all know this already. petrarchan47คุ 01:38, 12 June 2015 (UTC)

Petrarchan47 Are you aware that what you are calling "Mayo clinic" is in fact something in their "expert answers" series and is written by one individual doctor (Brent A. Bauer, M.D.)? Even then Dr Bauer writes that "several cases of harm have been reported" which in no way undercuts the stronger sources' listing of adverse effects associated with consuming this stuff. What you are calling "Swedish medical center" is 2013 syndicated content from the EBSCO CAM Review Board which appears on multiple web sites. It also does not contradict the strong sources we use. Perhaps you might like to consider the relative strength and relevance of the sources you're championing. Alexbrn (talk) 08:18, 12 June 2015 (UTC)
Doc James agreed that extraordinary claims require extraordinary sources (mulitple) per WP:V. I'd hate to think people are going into Walmart to buy kombucha tea or derivative health drinks if there's a risk it could have toxic effects or cause death. We have the 2014 Journal review which is extraordinarily reliable because it not only meets MEDRS requirements, it also passes the acid test for WP:V. I don't see why Mayo and a NYTimes article couldn't be used to cite kombucha products, either. I think we're good to go in that regard. --Atsme📞📧 04:04, 12 June 2015 (UTC)
Either you have not read WP:V or you have not understood it. The principle of verifiability means that text on Wikipedia must be verifiable. To quote: "all quotations and any material challenged or likely to be challenged must be attributed to a reliable, published source using an inline citation". It does not mean that you have the job of personally "verifying" for yourself the work in secondary sources. For the avoidance of doubt, WP:MEDRS makes this explicit: "Do not reject a high-quality type of study due to personal objections to the study's inclusion criteria, references, funding sources, or conclusions." Talking of a source itself as "passing the acid test for WP:V" makes no sense. Alexbrn (talk) 10:42, 12 June 2015 (UTC)
Making broad "death" claims inst in the source either. It mentions "of at least one woman". Using just plain death can lead people to believe it is widespread. But you have decided to eliminate the quantitative facts in the source from the article in some strange sync claim. First you add your prefered claim to the body then you change the lede when it should just have been copied from the lede. AlbinoFerret 13:49, 12 June 2015 (UTC)
im going to have to concur with AlbunoFerret, (further logic dictates this line of "reasoning" has no objective bases , as indicated very early on the ref originally in question was quite dated, even further it does not come up on Google anymore??) --Ozzie10aaaa (talk) 14:17, 12 June 2015 (UTC)
@Ozzie10aaaa: per comments here, that ACS source has been removed and newer ones used. AlbinoFerret's edit that gives us "linked to ... the death of at least one person" is fine and supported by the sources currently used. Alexbrn (talk) 14:23, 12 June 2015 (UTC)

No, Alex, it is not fine for the reasons mentioned above which were further validated by Doc James in response to my questions. The claims you want included are unacceptable for the following the reasons:

  1. outdated or involve such a small group of people (1 rare case) that inclusion of such information is not only UNDUE, it is FRINGE. MEDRS works both ways.
  2. not one of the case reports is supported by scientific evidence that confirm causality,
  3. the claims involve anecdotal case studies which is a flat no-no per MEDRS, and
  4. the sources you cited contradict a more recent 2014 journal review wherein the conclusion statement is based in part on the same case reports cited in all other RS. There are no other reported cases of toxicity or death except for that same handful that is mirrored in all the sources.

It's time to drop the stick, Alex, and stop being condescending. Spend some time reviewing MEDRS which clearly states and accurately reflect current medical knowledge.  and WP:MEDASSESS:  Knowing the quality of the evidence helps editors distinguish between minority and majority viewpoints, determine due weight, and identify information that will be accepted as evidence-based medicine.' Not all papers in even reputable medical journals can be treated as equivalent. Studies can be categorized into a number of levels, and in general, editors should rely upon high-quality evidence, such as systematic reviews, rather than lower-quality evidence, such as case reports, or non-evidence, such as anecdotes or conventional wisdom. The medical guidelines or position statements produced by nationally or internationally recognised expert bodies often contain an assessment of the evidence as part of the report. Contradictory to the allegations made against me, we actually are obliged to verify the sources and make sure they are verifiable but not false as further defined in far more detail by guideline essays and MEDRS. If your intent is to get the article right then by all means join as a GF collaborator, but if your only purpose is to assault kombucha products with scientifically unsupported death claims based on inaccuracies in RS that fail MEDRS and V, then you are not being helpful. Oh, and I highly recommend a trip over to Red Bull where your collaboration may prove beneficial. There are plenty of sources you can cite linking Red Bull to deaths including the death of a prime athlete who according to RS dropped dead shortly after drinking 4 cans of the stuff. There is no mention of death whatsoever in the lead despite the case studies and academic papers. In fact the lead gives the drink a clean bill of health. The circumstances surrounding that "energy" drink are far more profound than the antecdotal case reports linking kombucha tea. You might also take a look at Gatorade. It may turn out to be a great way to help Doc James sniff out COIs. Happy editing! Atsme📞📧 15:40, 12 June 2015 (UTC)

Lots of confusion and original research there. Best if we WP:STICKTOSOURCE for the pharmacology textbook we cite (to quote it: "Kombucha has been associated with illnesses and death"), rather than adopt editors' personal views. Alexbrn (talk) 15:51, 12 June 2015 (UTC)
Sorry, but your position is neither supported by PAGs nor consensus. Also, please be mindful of the DS notice attached to the article. Have you received a DS CAM/PS notice this year? I believe you brought the DS to our attention on the article TP so you are aware it exists. Thank you and happy editing, Alex!!! Atsme📞📧 15:58, 12 June 2015 (UTC)

Wikipedia:Articles for deletion/Differential DVH

Members of this project are invited to comment. --Kudpung กุดผึ้ง (talk) 01:58, 10 June 2015 (UTC)

Thanks User:Kudpung. Commented Doc James (talk · contribs · email) 02:33, 10 June 2015 (UTC)
And what about Cumulative DVH? Either article should be renamed if they are not merged.96.52.0.249 (talk) 18:14, 12 June 2015 (UTC)

2015 bee venom therapy systematic review

https://www.ncbi.nlm.nih.gov/pubmed/25996493 This source might be useful. QuackGuru (talk) 07:09, 11 June 2015 (UTC)

ok, are you referring to Acupuncture you didn't indicate the article (I surmised from your editing history)--Ozzie10aaaa (talk) 10:35, 11 June 2015 (UTC)
If anywhere, this probably belongs at apitherapy, which needs some attention from this WikiProject. Everymorning talk 22:14, 11 June 2015 (UTC)
concur...but poster never indicated originally intended article--Ozzie10aaaa (talk) 22:17, 11 June 2015 (UTC)
User:Everymorning. User:Ozzie10aaaa. Apitherapy for this ref and Acupuncture#Related practices (and possibly apitherapy) for these two refs. QuackGuru (talk) 18:18, 12 June 2015 (UTC)

Request page move

Ruyan changed its company name to Dragonite International Limited. QuackGuru (talk) 18:24, 12 June 2015 (UTC)

if you have consensus then Help:How_to_move_a_page--Ozzie10aaaa (talk) 18:31, 12 June 2015 (UTC)

Meningeal lymphatic vessels

A fascinating paper at http://www.nature.com/nature/journal/vaop/ncurrent/fig_tab/nature14432_F3.html (Louveau, A.; Smirnov, I.; Keyes, T. J.; Eccles, J. D.; Rouhani, S. J.; Peske, J. D.; Derecki, N. C.; Castle, D.; Mandell, J. W.; Lee, K. S.; Harris, T. H.; Kipnis, J. (2015). "Structural and functional features of central nervous system lymphatic vessels". Nature. doi:10.1038/nature14432.) seems to be getting a lot of press attention. As this is primary research, I presume WP:MEDRS precludes the creation of an article on this at the moment, but how might it be possible to report interesting research which meets WP:RS but not WP:MEDRS? -- Impsswoon (talk) 18:55, 2 June 2015 (UTC)

a) one species (mice) b) one single paper. this is not encyclopedia worthy. (but wow!) Jytdog (talk) 20:01, 2 June 2015 (UTC)
agree with Jtydog--Ozzie10aaaa (talk) 22:52, 2 June 2015 (UTC)
If confirmed, a Nobel Prize worthy discovery. Wow indeed! Boghog (talk) 20:56, 3 June 2015 (UTC)
in regards to the original question by the poster... The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature... the discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction. again impressive, but still primary , however due to... Articles should be based on reliable, third-party, published sources with a reputation for fact-checking and accuracy. This means that we publish the opinions only of reliable authors, and not the opinions of Wikipedians who have read and interpreted primary source material for themselves. The following examples cover only some of the possible types of reliable sources and source reliability issues, and are not intended to be exhaustive. Proper sourcing always depends on context; common sense and editorial judgment are an indispensable part of the process you "could" mention it in Lymphatic_vessel having said that get concensus first...IMO --Ozzie10aaaa (talk) 12:41, 6 June 2015 (UTC)
I third the "neat finding" sentiment. :P Seppi333 (Insert ) 23:09, 12 June 2015 (UTC)

Summary of review

There is discussion of how we should summarize a cannabis review here and . Further input requested. Doc James (talk · contribs · email) 01:56, 13 June 2015 (UTC)

give opinion (I gave mine)--Ozzie10aaaa (talk) 09:36, 13 June 2015 (UTC)

Wikipedia:WikiProject Medicine/App

Hey All

We have just had a WikiMed App launch for android here . It is basically all our medical articles in a Kiwix automatically downloading format.

I have just updated the intro page which will soon be this Wikipedia:WikiProject_Medicine/Open_Textbook_of_Medicine and appreciate feedback.

Hope to have it translated into Chinese, Persian, and Oriya soon for launches into those languages.

Doc James (talk · contribs · email) 00:22, 12 June 2015 (UTC)

very well written and informative(looks good)--Ozzie10aaaa (talk) 00:52, 12 June 2015 (UTC)
This is 466mb. My guess is that the average app size is less than 10mb, and a big app would be 50mb. This is a big application. That matters a bit now, but will matter less in the future.
This is an extremely cool idea.
Is there any project page for this on English Wikipedia? Should I start one? Blue Rasberry (talk) 14:11, 12 June 2015 (UTC)
This is sort of the project page Wikipedia:WikiProject_Medicine/Open_Textbook_of_Medicine
We are looking at creating a version without pictures. Doc James (talk · contribs · email) 22:59, 12 June 2015 (UTC)
Just for a reference (no pun intended) I use an app called "WikiEM" which serves as a basic reference of notes and lab values - and this takes up about 200MB I believe on my phone. It might be a bit large, but as I do not have any way to guarantee that I will always have internet access I find it acceptable. I imagine this also would be perfect for residents and other hospital staff who often use Wikipedia at their workplace. I have two questions about it. i) is there an iOS app planned, and ii) do we have the approval we need to make the statement "Welcome to the Offline Medical Encyclopedia by Wikipedia" in the app description? Peter.Ctalkcontribs 15:06, 12 June 2015 (UTC)
Yes to all of those. Doc James (talk · contribs · email) 22:59, 12 June 2015 (UTC)

Have created a page to coordinate the building of the app here Wikipedia:WikiProject Medicine/App Doc James (talk · contribs · email) 12:37, 13 June 2015 (UTC)

Cochrane protocals as refs

What do people think of these as refs . They provide an overview, have a DOI, but are not pubmed indexed. They are protocals for a systematic review that is planned. Doc James (talk · contribs · email) 05:06, 28 May 2015 (UTC)

they look informative, (in terms of non-PubMed indexed, perhaps we could make an exception in this case?)--Ozzie10aaaa (talk) 10:48, 28 May 2015 (UTC)
It depends on how the paper is used. A lot of this paper has more to do with the culture of research in a field and a summary of what research is routinely conducted. I am not seeing a lot of health claims, so WP:MEDRS would not apply to most of it anyway.
This is a statement by professionals. A large amount of health information is not PubMed indexed, particularly in areas like this where the health information is what professionals in the field take for granted that everyone knows. It is a good paper for what it is. Blue Rasberry (talk) 13:48, 28 May 2015 (UTC)
So what I've used these protocols for is not any kind of claims to the effectiveness of the intervention, but simply the background information in the article. I've read a ton of Cochrane reviews and the background seems to be on par in quality with other reviews - so I think it's worthy of exception provided it's only being used for background. Emily Temple-Wood (NIOSH) (talk) 21:21, 28 May 2015 (UTC)
Okay. I am happy than. Doc James (talk · contribs · email) 12:23, 30 May 2015 (UTC)
Yay, thanks for getting this all clarified! :) Emily Temple-Wood (NIOSH) (talk) 02:15, 4 June 2015 (UTC)
This issue has come up once before. The concern was that no-one was sure if the protocol has yet undergone a peer review. Matthew Ferguson (talk) 13:16, 13 June 2015 (UTC)

Discussion notification: Gender identity disorder article

Notification to LGBT and Medicine wikiprojects of discussion at Talk:Gender identity disorder#Gender dysphoria as commonly recognisable and less judgemental name.

GregKaye 22:57, 13 June 2015 (UTC)

Note: I altered the heading of this section by adding ": Gender identity disorder article" to it so that it is specific as to what the section is about and will be easier to locate once archived. Flyer22 (talk) 23:21, 13 June 2015 (UTC)


please give opinion, (I did)--Ozzie10aaaa (talk) 00:18, 14 June 2015 (UTC)

Definition of a Gene

As the Gene article is about to be GA reviewed, it might be useful to check that there is consensus on the definitions (Talk:Gene#Definitions). T.Shafee(EvoEvo)talk 01:15, 14 June 2015 (UTC)

Wikipedia:Good_article_criteria--Ozzie10aaaa (talk) 10:47, 14 June 2015 (UTC)

Discussion notification Sex article

Notification to LGBT and Medicine wikiprojects of discussion at Talk:Sex#Sex, facing ambiguity relating to a potential move/renaming of this article. GregKaye 13:50, 14 June 2015 (UTC)

Making Sense of Allergies

Fyi, Making Sense of Allergies (published last week)

In my view at least, public information documents like this worked up by scientifically/medically reputable charities such as Sense about Science (similarly, say, to Cancer Research UK) can provide valid reliable sources conceived for the general public that is our primary readership. Cheers, 109.155.60.103 (talk) 09:33, 15 June 2015 (UTC)

For example for the fiscal year ending 5 April 2008, the trust received £145,902 in donations. Disclosed corporate donations comprised £88,000 with pharmaceutical company Astra Zeneca donating £35,000 ..? --Ozzie10aaaa (talk) 09:50, 15 June 2015 (UTC)
(...fwiw, that's quoted somewhat out of context.) 109.155.60.103 (talk) 11:07, 15 June 2015 (UTC)
Sense about Science is far from similar to Cancer Research UK. -Roxy the black and white dog™ (resonate) 11:17, 15 June 2015 (UTC)
There are some good reviews that cover this information. "The prevalence of reported penicillin allergy is 10% in the general population. However, more than 90% of these patients are found not to be allergic to penicillin after skin testing."
Some people love saying they are allergic to stuff. Doc James (talk · contribs · email) 11:20, 15 June 2015 (UTC)

Smallpox was / is an infectious disease

Discussion is occurring here Doc James (talk · contribs · email) 10:47, 15 June 2015 (UTC)

give opinion (I did)--Ozzie10aaaa (talk) 14:11, 15 June 2015 (UTC)

Route of administration articles + template

Route of administration and {{Routes of administration}} aren't harmonized; I figured I should mention it here in the event anyone wants to take a stab at making the template and article consistent/complete. Some of the links in {{Routes of administration}} are directed to an article on an anatomical region instead of an article on the route of administration associated with that region. Some routes of administration also lack an associated article on the topic or an article exists but ambiguously refers to the route of administration (e.g., title+lead vs scope mismatch, as in the epidural example below).

As an example, for the articles involving drug administration into the spine, there's spinal anaesthesia which covers spinal administration of anesthetics (into subarachnoid spaces), "intrathecal (administration)" (into subarachnoid spaces; the scope of intrathecal appears to be redundant with spinal anaesthesia), and epidural administration (into epidural spaces). I already moved the epidural article to epidural administration and copyedited it and the epidural (disambiguation) page accordingly to address this particular case. I wouldn't mind creating, moving, or redirecting the remaining articles myself; however, I'd need a comprehensive reference on medical/recreational routes of administration to do so since I've never formally studied topic.

So... anyone interested in tackling this issue or linking/emailing me such a reference? Seppi333 (Insert ) 19:28, 12 June 2015 (UTC)

Well, I found a comprehensive list at the FDA's website. It doesn't have a lot of information about each one, but my quick count indicates 111 different routes (who knew that there were so many?), not including "unknown" and "unassigned" (which are relevant for their paperwork, but not actual routes). WhatamIdoing (talk) 03:11, 13 June 2015 (UTC)
That's really all I needed - I can just look up specific routes based upon that. Thanks! Seppi333 (Insert ) 16:40, 14 June 2015 (UTC)
  • First of all, if dosage form and route of administration are actually the same, as the links say, then merge them or otherwise make their diff clear. For example to me as a Reader.-DePiep (talk) 20:33, 13 June 2015 (UTC)
  • I'm interested from another angle. I edit the {{Drugbox}} infobox, which of course has parameter | routes_of_administration= (RoA). I'd like to introduce a code-list for this RoA, so that easy input produces a correct and well-linked infobox test. (for example: |routes_of_administration=iv does show: Intravenous injection). So I'd like to know if there is a set of top options, we can abbreviate into code. WhatamIdoing counted 111 options, that's too much. But we can make a shortlist of ~20 obvious/common options, that would be nice. An example set is the pregnancy category options. -DePiep (talk) 20:49, 13 June 2015 (UTC)
Routes of administration are determined by the dosage form of a drug; e.g., a tablet can't utilize nasal administration (assuming it isn't powderized and insufflated), but it could be taken via the oral route or rectal route. Some dosage forms are typically associated with specific routes of administration; e.g., a suppository typically involves a rectal/vaginal route.
Based upon all the medical papers I've read, I'd say the most common general routes of administration used in preclinical research or in humans are oral administration, intraperitoneal administration (i.p.), intravenous administration (i.v.), intramuscular administration (i.m.), subcutaneous administration (s.c.), nasal administration (this includes insufflation (medicine), which involves a specific dosage form, but insufflation is commonly used in drugboxes), inhalation (this includes recreational routes like smoking), topical administration, and rectal administration, assuming I haven't forgotten any. In preclinical research, injections into specific brain structures or regions (e.g., intra-accumbal or intra-striatal) is a very common route of administration, but I don't know of a catch-all term for this type of administration.
Buccal administration and sublingual administration aren't utilized medically anywhere near as much as the oral route in humans, but certain drugs like nicotine polacrilex utilize these as a primary route due to oral bioavailability issues. Intrathecal and epidural administration are notable routes, but they're also comparatively less common to those listed above, as they're applied by doctors/clinicians in hospitals/clinics instead of for use by the general populous.
Assuming I haven't forgotten any notable/major drug routes, the remainder are typically associated with very particular drugs/agents or are simply uncommonly used as a medical route in humans due to the feasibility of using a more standard drug route, like oral intake. Intravaginal administration is a notable medical route for particular drugs/devices and a somewhat less common recreational route; e.g., see History and culture of substituted amphetamines#Recreational routes of administration.
It's probably worth coding an abbreviated input for all of the above routes (excluding the preclinical one I noted). Seppi333 (Insert ) 16:40, 14 June 2015 (UTC)
Seppi333 thanks. Working on this sidenote of template shortcuts, when there is news I'll be back here. Leave it to you for the OP merge issue. -DePiep (talk) 20:59, 14 June 2015 (UTC)
No problem. :) Seppi333 (Insert ) 21:30, 14 June 2015 (UTC)
What about transdermal administration? It isnt a terribly common method but it is the way nicotine patches are administered and I would think it would be of interest to the general reader. Ca2james (talk) 18:52, 15 June 2015 (UTC)
We should be very careful here, as there are still, I expect, strong national preferences. Doctors on the old big ocean liners used to keep common drugs in 3 forms: injectable for the Americans and Germans, pills for the British, and suppositories for the French. Johnbod (talk) 14:29, 15 June 2015 (UTC)
Are you sure those were the doctors and not the bartenders? ;-) LeadSongDog come howl! 15:08, 15 June 2015 (UTC)
Johnbod that is so, so interesting. Thanks for sharing that. I had no idea administration practices were that variable. Jytdog (talk) 15:12, 15 June 2015 (UTC)
  • I like the comprehensive list provided by WhatamIdoing. I like DePiep's ideas of considering a merge between dosage form and route of administration, and of prioritizing about 20 main options over the list of 100+ options. The anatomical listings in the current version of the template seem more organized than the system being used in the current version of the article. I think right now, the article is sorted by a mix of anatomical and technique sortings. It would be ideal to derive the sorting system from an existing published source. I have not looked for one, but I see no obvious candidate at a glance. Blue Rasberry (talk) 17:39, 15 June 2015 (UTC)

Concerning refs

Some questionable refs are being used per this discussion here Talk:Phimosis#Content. Others thoughts? Doc James (talk · contribs · email) 22:45, 15 June 2015 (UTC)

please give opinion--Ozzie10aaaa (talk) 09:56, 16 June 2015 (UTC)

diabetic microvascular complications/review

recently published, I deem this a good read, enjoy.--Ozzie10aaaa (talk) 18:45, 16 June 2015 (UTC)

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