ZBTB14

Zinc finger and BTB domain-containing protein 14 is a protein that in humans is encoded by the ZBTB14 gene (previously ZFP161).^[5][6] The ZBTB14 protein acts as a transcription activator for the dopamine transporter, while instead acting as a transcription repressor for FMR1, MYC, and thymidine kinases.^[7]

AliasesZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14

External IDsOMIM: 602126; MGI: 1195345; GeneCards: ZBTB14

Chr.Chromosome 18 (human)^[1]

End5,297,053 bp^[1]

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ZBTB14
Identifiers
Aliases	ZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14
External IDs	OMIM: 602126; MGI: 1195345; GeneCards: ZBTB14
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 5,289,019 bp[1] End 5,297,053 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.3|17 40.42 cM Start 69,690,045 bp[2] End 69,698,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon lymph node monocyte granulocyte ganglionic eminence gallbladder ventricular zone C1 segment gonad rectum Top expressed in ureter condyle Paneth cell ciliary body fossa medullary collecting duct lacrimal gland ascending aorta cumulus cell aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nucleolus cytosol aggresome Biological process cardiac septum development heart valve development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated coronary vasculature development transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7541 22666 Ensembl ENSG00000198081 ENSMUSG00000049672 UniProt O43829 Q08376 RefSeq (mRNA) NM_003409 NM_001143823 NM_001243702 NM_001243704 NM_009547 NM_001356282 NM_001356283 RefSeq (protein) NP_001137295 NP_001230631 NP_001230633 NP_003400 NP_033573 NP_001343211 NP_001343212 Location (UCSC) Chr 18: 5.29 – 5.3 Mb Chr 17: 69.69 – 69.7 Mb PubMed search [3] [4]
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