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Alpha-1D adrenergic receptor

Protein-coding gene in humans From Wikipedia, the free encyclopedia

The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5]

AliasesADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
End4,249,287 bp[1]
Quick facts ADRA1D, Identifiers ...
ADRA1D
Identifiers
AliasesADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDsOMIM: 104219; MGI: 106673; GeneCards: ADRA1D
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000678

NM_013460

RefSeq (protein)

NP_000669
NP_000669.1

NP_038488

Location (UCSC)Chr 20: 4.22 – 4.25 MbChr 2: 131.39 – 131.4 Mb
PubMed search[3][4]
Wikidata
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Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[5]

Ligands

Many α1 receptor ligands are non-selective for receptor subtypes.

Antagonists

See also

References

Further reading

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