β-Lysine
Chemical compound
From Wikipedia, the free encyclopedia
β-Lysine (3,6-diaminohexanoic acid[1]) is an amino acid produced by platelets during coagulation and is directly antibacterial by causing lysis of many Gram positive bacteria by acting as a cationic detergent.[2] Beta Lysine contains a side chain with an amino group and is the beta form of the amino acid Lysine. Beta-Lysine can hydrogen bond at its carboxylic acid residue.[3] Lysine is an amino acid that acts as a site for ubiquitination enzymes to bind to and branch from.[4] Lysine is a positively charged amino acid due to its amino side chain (that contains an amine). This allows Beta-Lysine to directly interact with the negatively charged phosphate groups within nucleotides.[4]
| Names | |
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| IUPAC name
3,6-Diaminohexanoic acid | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C6H14N2O2 | |
| Molar mass | 146.190 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Beta-lysine is a non-specific immune defense factor that can be found in the blood of many animals, including birds this contributes to the innate immune system.[5] Beta-Lysine in turn, can be a form of measure, of overall immune activity.[5] Beta-Lysine activity is also responsive to many immunomodulators, such as preparations containing bacterial lipopolysaccharides, which increase the musical immune response which then leads to an increase in Beta-Lysine activity, further solidifying Beta-Lysine as an indicator and form of measure for innate immune response.
