Glucosa-6-fosfato isomerasa
proteína encontrada en Homo sapiens
From Wikipedia, the free encyclopedia
La glucosa-6-fosfato isomerasa (EC 5.3.1.9) es una enzima, presente en gran parte de los seres vivos; cataliza la reacción reversible de glucosa-6-fosfato a fructosa-6-fosfato. En el citoplasma, forma parte de las rutas metabólicas de la glucólisis y la gluconeogénesis, y en la matriz extracelular funciona como factor neurotrófico para cierto tipo de neuronas.
Nomenclatura
Otros nombres
Fosfohexosa isomerasa, fosfohexomutasa, oxoisomerasa, hexosa fosfato isomerasa, fosfosacaromutasa, fosfoglucoisomerasa, fosfohexoisomerasa, fosfoglucosa isomerasa, glucosa-fosfato isomerasa, D-glucosa-6-fosfato cetol-isomerasa, neuroleucina, antígeno espermático-36
Símbolos
GPI (HGNC: 4458) AMF; NLK; PGI; PHI; GNPI; SA-36
Identificadores
externosGeneCards: Gen GPI UniProt: GPI
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
externos
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
La reacción es la siguiente:
 |
| Glucosa-6-fosfato ⇌ Fructosa-6-fosfato |
Bibliografía
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- Brownstein BH, Silverman GA, Little RD, et al. (1989). «Isolation of single-copy human genes from a library of yeast artificial chromosome clones.». Science 244 (4910): 1348-51. PMID 2544027. doi:10.1126/science.2544027.
- Mizrachi Y (1989). «Neurotrophic activity of monomeric glucophosphoisomerase was blocked by human immunodeficiency virus (HIV-1) and peptides from HIV-1 envelope glycoprotein.». J. Neurosci. Res. 23 (2): 217-24. PMID 2547084. doi:10.1002/jnr.490230212.
- Gurney ME, Apatoff BR, Spear GT, et al. (1986). «Neuroleukin: a lymphokine product of lectin-stimulated T cells.». Science 234 (4776): 574-81. PMID 3020690. doi:10.1126/science.3020690.
- Faik P, Walker JI, Redmill AA, Morgan MJ (1988). «Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences.». Nature 332 (6163): 455-7. PMID 3352745. doi:10.1038/332455a0.
- Zanella A, Izzo C, Rebulla P, et al. (1981). «The first stable variant of erythrocyte glucose-phosphate isomerase associated with severe hemolytic anemia.». Am. J. Hematol. 9 (1): 1-11. PMID 7435496. doi:10.1002/ajh.2830090102.
- Faik P, Walker JI, Morgan MJ (1994). «Identification of a novel tandemly repeated sequence present in an intron of the glucose phosphate isomerase (GPI) gene in mouse and man.». Genomics 21 (1): 122-7. PMID 7545951. doi:10.1006/geno.1994.1233.
- Xu W, Beutler E (1995). «The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia.». J. Clin. Invest. 94 (6): 2326-9. PMC 330061. PMID 7989588. doi:10.1172/JCI117597.
- Xu W, Lee P, Beutler E (1996). «Human glucose phosphate isomerase: exon mapping and gene structure.». Genomics 29 (3): 732-9. PMID 8575767. doi:10.1006/geno.1995.9944.
- Baronciani L, Zanella A, Bianchi P, et al. (1996). «Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia». Blood 88 (6): 2306-10. PMID 8822952.
- Beutler E, West C, Britton HA, et al. (1998). «Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).». Blood Cells Mol. Dis. 23 (3): 402-9. PMID 9446754. doi:10.1006/bcmd.1997.0157.
- Kanno H, Fujii H, Miwa S (1998). «Expression and enzymatic characterization of human glucose phosphate isomerase (GPI) variants accounting for GPI deficiency.». Blood Cells Mol. Dis. 24 (1): 54-61. PMID 9616041. doi:10.1006/bcmd.1998.0170.
- Kugler W, Breme K, Laspe P, et al. (1998). «Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.». Hum. Genet. 103 (4): 450-4. PMID 9856489. doi:10.1007/s004390050849.
- Belyaeva OV, Balanovsky OP, Ashworth LK, et al. (1999). «Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studies.». Gene 230 (2): 259-66. PMID 10216265. doi:10.1016/S0378-1119(99)00056-6.
- Yakirevich E, Naot Y (2000). «Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination.». Biol. Reprod. 62 (4): 1016-23. PMID 10727272. doi:10.1095/biolreprod62.4.1016.
- Haga A, Niinaka Y, Raz A (2000). «Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.». Biochim. Biophys. Acta 1480 (1-2): 235-44. PMID 11004567. doi:10.1016/s0167-4838(00)00075-3.
Datos: Q418097
Multimedia: Phosphoglucose isomerase, PGI / Q418097
