Glycine décarboxylase

From Wikipedia, the free encyclopedia

Glycine déshydrogénase (décarboxylante)

Données clés
N° EC	EC 1.4.4.2
N° CAS	37259-67-9
Cofacteur(s)	PLP

Activité enzymatique
IUBMB	Entrée IUBMB
IntEnz	Vue IntEnz
BRENDA	Entrée BRENDA
KEGG	Entrée KEGG
MetaCyc	Voie métabolique
PRIAM	Profil
PDB	RCSB PDB PDBe PDBj PDBsum
GO	AmiGO / EGO

La glycine décarboxylase, ou glycine déshydrogénase (décarboxylante), est une oxydoréductase qui catalyse la réaction : glycine + [protéine H du système de clivage de la glycine]-N⁶-lipoyl-L-lysine $\rightleftharpoons$ [protéine H du système de clivage de la glycine]-S-aminométhyl-N⁶-dihydrolipoyl-L-lysine + CO₂.

Cette enzyme est l'un des quatre composants du système de clivage de la glycine, qui intervient en réponse à des taux élevés de glycine, aussi bien chez les humains que chez les plantes où elle intervient dans la photorespiration au sein des chloroplastes.

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(en) Strausberg RL, Feingold EA, Grouse LH, et al., « Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences », Proc. Natl. Acad. Sci. U.S.A., vol. 99, n^o 26,‎ 2003, p. 16899–903 (PMID 12477932, PMCID 139241, DOI 10.1073/pnas.242603899)
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(en) Dinopoulos A, Kure S, Chuck G, et al., « Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults », Neurology, vol. 64, n^o 7,‎ 2006, p. 1255–7 (PMID 15824356, DOI 10.1212/01.WNL.0000156800.23776.40)
(en) Flusser H, Korman SH, Sato K, et al., « Mild glycine encephalopathy (NKH) in a large kindred due to a silent exonic GLDC splice mutation », Neurology, vol. 64, n^o 8,‎ 2006, p. 1426–30 (PMID 15851735, DOI 10.1212/01.WNL.0000158475.12907.D6)
(en) Boneh A, Korman SH, Sato K, et al., « A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem », J. Hum. Genet., vol. 50, n^o 5,‎ 2005, p. 230–4 (PMID 15864413, DOI 10.1007/s10038-005-0243-y)
(en) Kimura K, Wakamatsu A, Suzuki Y, et al., « Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes », Genome Res., vol. 16, n^o 1,‎ 2006, p. 55–65 (PMID 16344560, PMCID 1356129, DOI 10.1101/gr.4039406)
(en) Korman SH, Wexler ID, Gutman A, et al., « Treatment from birth of nonketotic hyperglycinemia due to a novel GLDC mutation », Ann. Neurol., vol. 59, n^o 2,‎ 2006, p. 411–5 (PMID 16404748, DOI 10.1002/ana.20759)

Glycine décarboxylase

Notes et références

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