Interleukine 10

IL10
	Structure cristalline de l'IL-10 telle que publiée dans la Protein Data Bank (PDB : 2H24)
Structures disponibles
PDB	Recherche d'orthologue : PDBe RCSB
Identifiants PDB
	1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Identifiants
Alias	IL10, human cytokine synthesis inhibitory factor, Interleukine 10, CSIF
IDs externes	OMIM: 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	206,774,541 bp
Position du gène (souris)
Chr.	Chromosome 1 (souris)
Fin	130,952,711 bp
Expression génique
	Fortement exprimé dans
	appendice iléo-cæcal; ; vésicule biliaire; ; cartilage tissue; ; rate; ; left uterine tube; ; ganglion lymphatique; ; muqueuse gastrique; ; right adrenal cortex; ; left adrenal cortex; ; granulocyte;
	Fortement exprimé dans
	embryon; ; embryon; ; lumbar subsegment of spinal cord; ; stroma of bone marrow; ; cortex entorhinal; ; épiblaste; ; lumbar spinal ganglion; ; thymus; ; tracheobronchial tree; ; strie vasculaire;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; growth factor activity; cytokine activity; interleukin-10 receptor binding; protein dimerization activity;
Composant cellulaire	région extracellulaire; milieu extracellulaire;
Processus biologique	negative regulation of chronic inflammatory response to antigenic stimulus; positive regulation of MHC class II biosynthetic process; negative regulation of endothelial cell apoptotic process; hématopoïèse; negative regulation of interferon-gamma production; regulation of sensory perception of pain; positive regulation of B cell apoptotic process; negative regulation of chemokine (C-C motif) ligand 5 production; response to inactivity; negative regulation of cytokine activity; negative regulation of interleukin-1 production; cellular response to hepatocyte growth factor stimulus; cellular response to estradiol stimulus; negative regulation of interleukin-6 production; vieillissement; positive regulation of DNA-binding transcription factor activity; negative regulation of apoptotic process; negative regulation of cytokine production involved in immune response; response to glucocorticoid; cytoplasmic sequestering of NF-kappaB; negative regulation of interleukin-18 production; negative regulation of MHC class II biosynthetic process; response to activity; response to organic substance; response to carbon monoxide; leukocyte chemotaxis; type 2 immune response; negative regulation of myeloid dendritic cell activation; response to insulin; negative regulation of interleukin-8 production; response to lipopolysaccharide; B cell proliferation; negative regulation of T cell proliferation; negative regulation of nitric oxide biosynthetic process; branching involved in labyrinthine layer morphogenesis; defense response to bacterium; regulation of complement-dependent cytotoxicity; réponse immunitaire; régulation de l'expression des gènes; B cell differentiation; regulation of isotype switching; negative regulation of tumor necrosis factor production; negative regulation of membrane protein ectodomain proteolysis; réponse inflammatoire; cellular response to lipopolysaccharide; negative regulation of B cell proliferation; negative regulation of inflammatory response; negative regulation of cytokine production; positive regulation of transcription by RNA polymerase II; negative regulation of interleukin-12 production; defense response to protozoan; negative regulation of sensory perception of pain; positive regulation of macrophage activation; régénération du foie; regulation of synapse organization; positive regulation of endothelial cell proliferation; negative regulation of cell population proliferation; negative regulation of heterotypic cell-cell adhesion; positive regulation of heterotypic cell-cell adhesion; positive regulation of cell cycle; negative regulation of mitotic cell cycle; endothelial cell apoptotic process; regulation of response to wounding; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell proliferation; interleukin-12-mediated signaling pathway; régulation positive de la transcription dépendante de l'ADN; negative regulation of autophagy; cytokine-mediated signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of hydrogen peroxide-induced neuron death; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologues
	3586
	16153
	ENSG00000136634
	ENSMUSG00000016529
	P22301
	P18893
	NM_000572
	NM_010548
	NP_000563
	NP_034678
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

L'Interleukine 10 (IL10), parfois appelé CSIF (de l'anglais : human cytokine synthesis inhibitory factor) est une protéine produite par différentes cellules sanguines et agissant en diminuant la réponse immunitaire. Son gène est le IL10 situé sur le chromosome 1 humain.