(R)-dehydropantoate dehydrogenase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, (R)-dehydropantoate dehydrogenase (EC 1.2.1.33) is an enzyme that catalyzes the chemical reaction
-3,3-dimethylmalic_acid.svg)
-4-dehydropantoic_acid.svg)
| (R)-dehydropantoate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.33 | ||||||||
| CAS no. | 37250-96-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are (R)-4-dehydropantoic acid, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are (R)-3,3-dimethylmalic acid, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.
