(RS)-norcoclaurine 6-O-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, (RS)-norcoclaurine 6-O-methyltransferase (EC 2.1.1.128) is an enzyme that catalyzes the chemical reaction:[1][2][3]
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| (RS)-norcoclaurine 6-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.128 | ||||||||
| CAS no. | 167398-06-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In this methylation reaction, the enzyme uses the cofactor, S-adenosyl methionine (SAM) which transfers a methyl group, giving S-adenosyl-L-homocysteine (SAH) as a by-product. As the name of the enzyme implies, it also converts (R)-norclaurine to (R)-coclaurine.[4][5]
Family
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase. This enzyme participates in alkaloid biosynthesis.[5]
