(S)-tetrahydroprotoberberine N-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
(S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122) is an enzyme that catalyzes related methylation reactions in the biosynthesis of benzylisoquinoline alkaloids.
-cis-N-methylstylopine.svg)
| (S)-tetrahydroprotoberberine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.122 | ||||||||
| CAS no. | 106878-42-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
For example, (S)-stylopine is converted to (S)-cis-N-methylstylopine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Eschscholtzia californica. It methylates (S)-canadine and (S)-tetrahydropalmatine in a similar way.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase. This enzyme is also called tetrahydroprotoberberine cis-N-methyltransferase. It participates in alkaloid biosynthesis.[2]
