1,2-dehydroreticulinium reductase (NADPH)
Class of enzymes
From Wikipedia, the free encyclopedia
1,2-dehydroreticulinium reductase (NADPH) (EC 1.5.1.27) is an enzyme that catalyzes the chemical reaction
-reticuline.svg)
| 1,2-dehydroreticulinium reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.1.27 | ||||||||
| CAS no. | 130590-58-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are 1,2-dehydroreticulinium cation, reduced nicotinamide adenine dinucleotide phosphate (NADPH) and a proton. Its products are (R)-reticuline and oxidised NADP+. The enzyme does not catalyse the reverse (oxidation) reaction.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-reticuline:NADP+ oxidoreductase. This enzyme is also called 1,2-dehydroreticulinium ion reductase. It participates in morphinan alkaloid biosynthesis.[1]
In the opium poppy, Papaver somniferum, this enzyme forms a fusion protein with 1,2-dehydroreticuline synthase, which converts (S)-reticuline to reticulinylium cation. The overall result is that the (S) enantiomer of reticuline is converted to {R)-reticuline, which is the precursor of salutaridine, on the pathway to morphine.[3] This gene fusion event has been suggested to evolve only once, about 20 million years ago.[4][5]
-reticuline.svg)
