1-Boc-4-AP

1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others. It is an N-protected derivative of 4-anilinopiperidine which can be readily converted to fentanyl or related analogues in several straightforward synthetic steps. It was classified as a DEA List 1 Chemical in 2022, and is also controlled in various other jurisdictions. Its possession, sale and importation are consequently heavily regulated throughout much of the world.^[1] 1-Boc-4-AP has also been identified as an impurity in other designer drug products, though it is unclear if it has any pharmacological activity in its own right.^[2]

Legal status

• US: List 1

CAS Number

• 125541-22-2

PubChem CID

• 1491502

ChemSpider

• 1231607

Quick facts Legal status, Identifiers ...

1-Boc-4-AP

Legal status
Legal status	US: List 1
Identifiers
IUPAC name tert-butyl 4-anilinopiperidine-1-carboxylate
CAS Number	125541-22-2
PubChem CID	1491502
ChemSpider	1231607
UNII	5PB6P54SRS
ChEMBL	ChEMBL1574621
CompTox Dashboard (EPA)	DTXSID90363439
Chemical and physical data
Formula	C16H24N2O2
Molar mass	276.380 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)OC(=O)N1CCC(CC1)NC2=CC=CC=C2
InChI InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-11-9-14(10-12-18)17-13-7-5-4-6-8-13/h4-8,14,17H,9-12H2,1-3H3 Key:HTIWISWAPVQGMI-UHFFFAOYSA-N

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