12-hydroxydihydrochelirubine 12-O-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
12-hydroxydihydrochelirubine 12-O-methyltransferase (EC 2.1.1.120) is an enzyme that catalyzes the chemical reaction
| 12-hydroxydihydrochelirubine 12-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.120 | ||||||||
| CAS no. | 158736-40-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This is a methylation reaction in which the benzylisoquinoline alkaloid, 12-hydroxydihydrochelirubine, is converted to dihydromacarpine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Thalictrum bulgaricum.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase.[2] The reaction is a late step in the biosynthesis of benzophenanthridine alkaloid, macarpine.[1]
