17β-Aminoestrogen
Class of chemical compounds
From Wikipedia, the free encyclopedia
17β-Aminoestrogens are a group of synthetic, steroidal estrogens derived from estradiol which have an amine substitution in place of the hydroxyl group at the C17β position.[1][2] They are estrogenic similarly,[1] but, unlike estradiol, show sustained anticoagulant activity that appears to be mediated by non-genomic mechanisms.[2] As such, it is thought that they may have a reduced risk of venous thromboembolism.[2] The 17β-aminoestrogens include the base or parent estrogen aminoestradiol (AE2)[3] and the extended-chain derivatives butolame, hexolame, pentolame, prodiame, and prolame.[1][2] They are a homologous series of steroids.[4]
