2,4,6-TMPEA-NBOMe

2,4,6-TMPEA-NBOMe, also known as ψ-2C-O-NBOMe or 26O-NBOMe as well as N-(2-methoxybenzyl)-2,4,6-trimethoxyphenethylamine, is a psychedelic drug of the phenethylamine, ψ-PEA, and N-benzylphenethylamine (NBOMe) families.^{[1][2][3][4][5]} It is the NBOMe derivative of ψ-2C-O (2,4,6-TMPEA).^[5] The drug is said to produce psychedelic effects such as visuals.^[1][2] It has been found to act as a potent serotonin 5-HT_2A receptor partial agonist, with an EC₅₀Tooltip half-maximal effective concentration of 1.7 nM and an E_maxTooltip maximal efficacy of 49%.^[3][4] 2,4,6-TMPEA-NBOMe was first described in the scientific literature in 2009.^[3][4] Subsequently, it was encountered as a novel designer drug in Russia in 2015.^[5][1][2] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.^[6]

Other namesψ-2C-O-NBOMe; 26O-NBOMe; NBOMe-TMPEA-6; N-(2-Methoxybenzyl)-2,4,6-trimethoxyphenethylamine

Routes of
administrationOral, intranasal^[1][2]

Drug classSerotonin 5-HT_2A receptor agonist; Serotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

2,4,6-TMPEA-NBOMe

Clinical data
Other names	ψ-2C-O-NBOMe; 26O-NBOMe; NBOMe-TMPEA-6; N-(2-Methoxybenzyl)-2,4,6-trimethoxyphenethylamine
Routes of administration	Oral, intranasal[1][2]
Drug class	Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name N-[(2-methoxyphenyl)methyl]-2-(2,4,6-trimethoxyphenyl)ethan-1-amine
CAS Number	1335331-68-4
Chemical and physical data
Formula	C19H25NO4
Molar mass	331.412 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc1cc(OC)c(c(c1)OC)CCNCc1ccccc1OC
InChI InChI=1S/C19H25NO4/c1-21-15-11-18(23-3)16(19(12-15)24-4)9-10-20-13-14-7-5-6-8-17(14)22-2/h5-8,11-12,20H,9-10,13H2,1-4H3 Key:NTLHTSWPAAMHIC-UHFFFAOYSA-N

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