2C-T-7

In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2C-T-7's dose as 10 to 30 mg orally and its duration as 8 to 15 hours.^[1][10][11] Its onset is said to be 2 hours.^[1]

The effects of 2C-T-7 have been reported to include closed-eye visuals like Escher-like graphics, open-eye visuals including visual movement, flowing, aliveness, velvety appearance, and increased depth perception, emotional fluctuations, insights, music enhancement, nausea, bodily tension, and muscle tightness, among others.^{[1][8][12][13][14]} Shulgin rated it as one of the "magical half-dozen" most important psychedelic phenethylamines, together with mescaline, 2C-B, and 2C-T-2.^[1]

2C-T-7 is metabolized by the monoamine oxidase (MAO) enzymes MAO-A and MAO-B.^[15][16] Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, moclobemide, and selegiline may potentiate the effects of 2C-T-7.^[15][16][17] This may result in overdose and serious toxicity.^[17][15]

There have been at least three reported deaths related to 2C-T-7 use as of August 2007, mainly at insufflated (snorted) doses of 30 mg or more.^[18][19] In the fall of 2000, a young healthy male died following insufflation of an excessive amount of 2C-T-7. Two additional deaths reported in April 2001 have been linked to 2C-T-7. These two deaths were reported by the DEA as being the result of the co-abuse of 2C-T-7 with MDMA.^[20]

In January 2002, Rolling Stone published an article about 2C-T-7 entitled "The New (legal) Killer Drug".^[21] Although the article suggested that the drug was legal, the legal status of 2C-T-7 was ambiguous at the time due to the United States' Federal Analogue Act.^[22] A detailed response on the website disinfo.com challenged the accuracy of much of the reporting in the aforementioned Rolling Stone article.^[23] 2C-T-7 has since been officially made illegal and declared a schedule 1 substance in the United States.^[24]

The Partnership for a Drug-Free America reported in 2006 that 2C-T-7 can be lethal even in small doses;^[25] however, they provide no source for their claim and of the three known deaths (as of August 2007) of 2C-T-7 intoxicated individuals, all involved either uncommonly large insufflated doses or the concomitant ingestion of other stimulants such as ephedrine and/or MDMA.

All of the three aforementioned known deaths of individuals under the influence of 2C-T-7 occurred in those known to be either intoxicated with other stimulants such as ephedrine or MDMA (which are known to be potentially lethal in certain situations or at excessive doses)^[26] or after the individual insufflated an amount of 2C-T-7 much greater than necessary to induce the full range of effects typically sought after by users of the drug; for example, the reported 35 mg insufflated dose taken by the individual who died in the fall of 2000. This reported dose was characterized as "excessive" by the United States DEA.

2C-T-7 was first described in the scientific literature by Myron Stolaroff by 1990.^[8] It was developed by Alexander Shulgin and Peyton Jacob III.^[8][9][1] Subsequently, 2C-T-7 was described in greater detail by Shulgin and colleagues in 1991.^[9][1]

Up until Operation Web Tryp and three deaths, two of which involved the use of other drugs in addition to 2C-T-7, and one which involved an excessive insufflated dose, 2C-T-7 was sold commercially in Dutch and Japanese smartshops and online.^[3][4]

• 2C (psychedelics)