2-Amino-4-deoxychorismate dehydrogenase
Class of enzymes
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2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.8.16, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
(1)
+ FMN
anthranilic_acid.svg)
(2)
+ FMNH2
| 2-amino-4-deoxychorismate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.8.16 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
It converts 2-amino-2-deoxyisochorismic acid (1) into 3-(1-carboxyvinyloxy)anthranilic acid (2) by oxidation using flavin mononucleotide (FMN) as its cofactor.[3]
This reaction is part of the biosynthesis of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. The intermediate acid (1) is produced from chorismic acid by the enzyme 2-amino-4-deoxychorismate synthase:[1]
