2-Amino-4-deoxychorismate synthase
Class of enzymes
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2-amino-4-deoxychorismate synthase (EC 2.6.1.86, ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| 2-amino-4-deoxychorismate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.86 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This reaction is an early part of the biosynthesis of the benzoxazolinate fragment of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. 2-amino-2-deoxyisochorismic acid is produced from chorismic acid by transamination using glutamine as the source of the amino group:[1]
The enzyme requires Mg2+.[5]
