2-Fluoromethcathinone
Designer stimulant
From Wikipedia, the free encyclopedia
2-Fluoromethcathinone (2-FMC), also known as 2-flephedrone, is a psychostimulant and designer drug of the cathinone family.[1][2][3][4] It acts as a dopamine and norepinephrine releasing agent (NDRA).[4]
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| Other names | 2-FMC; 2-Fluoromethylcathinone; 2-Fluoro-N-methylcathinone; 2-Flephedrone |
| Drug class | Stimulant; Norepinephrine–dopamine releasing agent |
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| Formula | C10H12FNO |
| Molar mass | 181.210 g·mol−1 |
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Pharmacology
The drug has an EC50 for dopamine release of 48.7 nM and induces 85% release of norepinephrine at a concentration of 10 μM.[4] For comparison, the EC50 values of methcathinone are 49.9 nM for dopamine release and 22.4 nM for norepinephrine release and it induces 100% release of norepinephrine at a concentration of 10 μM.[4][5] Hence, compared to methcathinone, 2-FMC appears to be relatively more selective or efficacious for induction of dopamine release over norepinephrine release.[4][5] It is notable in this regard that selective dopamine releasing agents are largely unknown.[6][4]