2001 California League season

• The Bakersfield Blaze ended their affiliation with the San Francisco Giants and began a new affiliation with the Tampa Bay Devil Rays.
• The High Desert Mavericks ended their affiliation with the Arizona Diamondbacks and began a new affiliation with the Milwaukee Brewers.
• The Lake Elsinore Storm ended their affiliation with the Anaheim Angels and began a new affiliation with the San Diego Padres.
• The Lancaster JetHawks ended their affiliation with the Seattle Mariners and began a new affiliation with the Arizona Diamondbacks.
• The Mudville Nine ended their affiliation with the Milwaukee Brewers and began a new affiliation with the Cincinnati Reds.
• The Rancho Cucamonga Quakes ended their affiliation with the San Diego Padres and began a new affiliation with the Anaheim Angels.
• The San Bernardino Stampede ended their affiliation with the Los Angeles Dodgers and began a new affiliation with the Seattle Mariners.

• The Lake Elsinore Storm finished with the best record in the regular season for the first time in team history.

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• The final round of the playoffs was cancelled after three games due to the September 11 terrorist attacks on New York and Washington, D.C.. The Lake Elsinore Storm and San Jose Giants were declared co-champions.
• The Lake Elsinore Storm won their second championship in team history.
• The San Jose Giants won their fifth championship in team history.