| 2004 regular season game log: 80–82 (Home: 44–37; Away: 36–45)[6] |
April: 9–13 (Home: 5–5; Away: 4–8)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 1 | April 5 | | @ Twins | 4–7 (11) | Rincon (1–0) | Durbin (0–1) | — | | 49,584 | 0–1 | L1 |
| 2 | April 6 | | @ Twins | 6–7 (15) | Roa (1–0) | Westbrook (0–1) | — | | 19,832 | 0–2 | L2 |
| 3 | April 7 | | @ Twins | 11–4 | Durbin (1–1) | Lohse (0–1) | — | | 20,313 | 1–2 | W1 |
| 4 | April 8 | | @ Royals | 6–1 | D'Amico (1–0) | Affeldt (0–1) | — | | 14,671 | 2–2 | W2 |
| 5 | April 9 | | @ Royals | 1–3 | Grimsley (1–0) | Cressend (0–1) | Leskanic (1) | | 28,535 | 2–3 | L1 |
| 6 | April 10 | | @ Royals | 6–7 (10) | Sullivan (1–0) | Betancourt (0–1) | — | | 21,889 | 2–4 | L2 |
| 7 | April 11 | | @ Royals | 3–5 | Sullivan (2–0) | Jiménez (0–1) | Leskanic (2) | | 16,933 | 2–5 | L3 |
| 8 | April 12 | | Twins | 6–3 | Lee (1–0) | Lohse (0–2) | — | | 42,424 | 3–5 | W1 |
| 9 | April 14 | | Twins | 6–10 | Silva (1–0) | D'Amico (1–1) | Rincon (1) | | 14,237 | 3–6 | L1 |
| 10 | April 15 | | Twins | 0–3 | Radke (2–0) | Stanford (0–1) | Nathan (1) | | 15,105 | 3–7 | L2 |
| 11 | April 16 | | Tigers | 10–3 | Sabathia (1–0) | Cornejo (1–1) | — | | 18,507 | 4–7 | W1 |
| 12 | April 17 | | Tigers | 1–6 | Maroth (2–0) | Davis (0–1) | — | | 18,155 | 4–8 | L1 |
| 13 | April 18 | | Tigers | 9–7 | Lee (2–0) | Bonderman (1–1) | Riske (1) | | 19,240 | 5–8 | W1 |
| 14 | April 19 | | Tigers | 4–10 | Levine (1–0) | Betancourt (0–2) | — | | 13,650 | 5–9 | L1 |
| 15 | April 20 | | Royals | 5–15 | Anderson (1–0) | Durbin (1–2) | — | | 13,563 | 5–10 | L2 |
| – | April 21 | | Royals | Postponed (rain, makeup July 24) |
| 16 | April 22 | | Royals | 5–4 | Betancourt (1–2) | Grimsley (1–1) | Riske (2) | | 15,720 | 6–10 | W1 |
| 17 | April 23 | | @ Tigers | 3–17 | Bonderman (2–1) | Davis (0–2) | Yan (1) | | 22,008 | 6–11 | L1 |
| 18 | April 24 | | @ Tigers | 2–5 | Urbina (1–0) | Stewart (0–1) | — | | 20,913 | 6–12 | L2 |
| 19 | April 25 | | @ Tigers | 3–2 | Westbrook (1–1) | Johnson (1–4) | — | | 17,253 | 7–12 | W1 |
| 20 | April 27 | | @ White Sox | 11–7 (10) | Betancourt (2–2) | Adkins (2–1) | — | | 14,572 | 8–12 | W2 |
| 21 | April 28 | | @ White Sox | 8–9 | Jackson (1–0) | Betancourt (2–3) | — | | 12,189 | 8–13 | L1 |
| 22 | April 30 | | Orioles | 11–2 | Lee (3–0) | Ponson (2–2) | — | | 18,782 | 9–13 | W1 |
|
May: 13–13 (Home: 11–6; Away: 2–7)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 23 | May 1 | | Orioles | 3–2 (13) | Durbin (2–2) | DeJean (0–2) | — | | 17,275 | 10–13 | W2 |
| – | May 2 | | Orioles | Postponed (rain, makeup June 14) |
| 24 | | 7:06 p.m. EDT | Red Sox | 2–1 | Westbrook (2–1) | Schilling (3–2) | Betancourt (1) | 2:52 | 16,285 | 11–13 | W3 |
| 25 | | 7:06 p.m. EDT | Red Sox | 7–6 | Davis (1–2) | Lowe (3–2) | Betancourt (2) | 2:50 | 16,070 | 12–13 | W4 |
| 26 | | 7:06 p.m. EDT | Red Sox | 5–9 | Arroyo (1–1) | D'Amico (1–2) | — | 3:17 | 17,370 | 12–14 | L1 |
| 27 | | 7:04 p.m. EDT | Red Sox | 2–5 | Martinez (4–2) | Sabathia (1–1) | Foulke (6) | 2:37 | 26,825 | 12–15 | L2 |
| 28 | May 7 | | @ Orioles | 2–3 (10) | Julio (1–0) | Durbin (2–3) | — | | 34,324 | 12–16 | L3 |
| 29 | May 8 | | @ Orioles | 7–10 | Parrish (3–1) | Stewart (0–2) | Julio (4) | | 30,687 | 12–17 | L4 |
| 30 | May 9 | | @ Orioles | 11–12 | Lopez (3–1) | Riske (0–1) | Julio (5) | | 35,778 | 12–18 | L5 |
| 31 | | 7:07 p.m. EDT | @ Red Sox | 10–6 | Durbin (3–3) | Kim (1–1) | — | 3:38 | 35,257 | 13–18 | W1 |
| 32 | | 7:05 p.m. EDT | @ Red Sox | 3–5 | Embree (1–0) | Jiménez (0–2) | Foulke (7) | 2:32 | 35,401 | 13–19 | L1 |
| 33 | | 7:06 p.m. EDT | @ Red Sox | 6–4 | Lee (4–0) | Wakefield (2–2) | — | 2:49 | 35,371 | 14–19 | W1 |
| 34 | May 14 | | Devil Rays | 8–7 (10) | White (1–0) | Carter (1–2) | — | | 19,796 | 15–19 | W2 |
| 35 | May 15 | | Devil Rays | 9–7 | Westbrook (3–1) | Zambrano (3–4) | — | | 18,040 | 16–19 | W3 |
| 36 | May 16 | | Devil Rays | 10–0 | Sabathia (2–1) | Waechter (1–4) | — | | 19,499 | 17–19 | W4 |
| 37 | May 17 | | White Sox | 7–2 | Lee (5–0) | Diaz (0–1) | — | | 15,617 | 18–19 | W5 |
| 38 | May 18 | | White Sox | 2–4 | Garland (3–2) | Durbin (3–4) | Koch (7) | | 15,298 | 18–20 | L1 |
| 39 | May 19 | | White Sox | 3–15 | Schoeneweis (4–1) | Davis (1–3) | — | | 17,205 | 18–21 | L2 |
| 40 | May 21 | | @ Devil Rays | 3–5 | Miller (1–1) | Sabathia (2–2) | Baez (6) | | 10,213 | 18–22 | L3 |
| 41 | May 22 | | @ Devil Rays | 3–6 | Waechter (2–4) | Westbrook (3–2) | Sosa (1) | | 12,008 | 18–23 | L4 |
| 42 | May 23 | | @ Devil Rays | 4–5 (10) | Harper (1–0) | Riske (0–2) | — | | 10,555 | 18–24 | L5 |
| 43 | May 25 | | Mariners | 4–5 (12) | Myers (2–1) | Jiménez (0–3) | Guardado (7) | | 15,349 | 18–25 | L6 |
| 44 | May 26 | | Mariners | 3–7 | Moyer (3–2) | Sabathia (2–3) | Guardado (8) | | 16,007 | 18–26 | L7 |
| 45 | May 27 | | Mariners | 9–5 | Westbrook (4–2) | Meche (1–5) | — | | 17,272 | 19–26 | W1 |
| 46 | May 28 | | Athletics | 1–0 | Jiménez (1–3) | Mecir (0–4) | — | | 19,257 | 20–26 | W2 |
| 47 | May 29 | | Athletics | 8–6 | Riske (1–2) | Rhodes (1–2) | Jiménez (1) | | 26,441 | 21–26 | W3 |
| 48 | May 30 | | Athletics | 4–3 | White (2–0) | Rhodes (1–3) | — | | 24,005 | 22–26 | W4 |
|
June: 15–13 (Home: 7–5; Away: 8–8)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 49 | June 1 | | Rangers | 5–6 (12) | Ramirez (3–2) | White (2–1) | Cordero (17) | | 17,136 | 22–27 | L1 |
| 50 | June 2 | | Rangers | 3–5 | Almanzar (5–0) | Betancourt (2–4) | Cordero (18) | | 18,098 | 22–28 | L2 |
| 51 | June 3 | | @ Angels | 2–5 | Escobar (4–2) | Lee (5–1) | — | | 39,353 | 22–29 | L3 |
| 52 | June 4 | | @ Angels | 9–6 | Riske (2–2) | Rodríguez (1–1) | Jiménez (2) | Angel Stadium of Anaheim | 43,590 | 23–29 | W1 |
| 53 | June 5 | | @ Angels | 3–2 | White (3–1) | Lackey (3–7) | Jiménez (3) | | 43,514 | 24–29 | W2 |
| 54 | June 6 | | @ Angels | 7–0 | Sabathia (3–3) | Colón (4–4) | — | | 43,337 | 25–29 | W3 |
| 55 | June 8 | | Marlins | 5–7 | Bump (1–3) | Jiménez (1–4) | Benitez (23) | | 21,252 | 25–30 | L1 |
| 56 | June 9 | | Marlins | 8–1 | Westbrook (5–2) | Burnett (0–2) | — | | 17,072 | 26–30 | W1 |
| 57 | June 10 | | Marlins | 1–4 | Pavano (6–2) | Davis (1–4) | Benitez (24) | | 19,113 | 26–31 | L1 |
| 58 | June 11 | | Reds | 6–5 (11) | Riske (3–2) | Norton (0–1) | — | | 27,308 | 27–31 | W1 |
| 59 | June 12 | | Reds | 8–7 | Betancourt (3–4) | Norton (0–2) | Jiménez (4) | | 42,101 | 28–31 | W2 |
| 60 | June 13 | | Reds | 10–8 | Miller (1–0) | Reith (2–2) | Jiménez (5) | | 31,235 | 29–31 | W3 |
| 61 | June 14 | | Orioles | 14–0 | Westbrook (6–2) | DuBose (4–5) | — | | 19,340 | 30–31 | W4 |
| 62 | June 15 | | @ Mets | 2–7 | Trachsel (6–5) | Davis (1–5) | — | | 22,783 | 30–32 | L1 |
| 63 | June 16 | | @ Mets | 9–1 | Sabathia (4–3) | Ginter (1–1) | — | | 29,512 | 31–32 | W1 |
| 64 | June 17 | | @ Mets | 2–6 | Bottalico (3–1) | White (3–2) | — | | 17,675 | 31–33 | L1 |
| 65 | June 18 | | @ Braves | 4–2 | Lee (6–1) | Hampton (1–7) | Jiménez (6) | | 28,000 | 32–33 | W1 |
| 66 | June 19 | | @ Braves | 0–4 | Byrd (1–0) | Westbrook (6–3) | Smoltz (11) | | 41,987 | 32–34 | L1 |
| 67 | June 20 | | @ Braves | 5–2 | Davis (2–5) | Ortiz (6–6) | Jiménez (7) | | 31,000 | 33–34 | W1 |
| 68 | June 21 | | @ White Sox | 5–1 | Sabathia (5–3) | Schoeneweis (5–6) | — | | 29,722 | 34–34 | W2 |
| 69 | June 22 | | @ White Sox | 9–11 (10) | Takatsu (4–0) | Jiménez (1–5) | — | | 27,922 | 34–35 | L1 |
| 70 | June 23 | | @ White Sox | 9–5 | Lee (7–1) | Buehrle (7–2) | — | | 21,654 | 35–35 | W1 |
| 71 | June 24 | | @ White Sox | 1–7 | Rauch (1–1) | Westbrook (6–4) | — | | 20,744 | 35–36 | L1 |
| 72 | June 25 | Rockies | 8–10 (10) | Reed (1–1) | Jiménez (1–6) | Chacon (16) | Jacobs Field | 22,642 | 35–37 | L2 |
| 73 | June 26 | Rockies | 4–3 (12) | Robertson (1–0) | Reed (1–2) | — | Jacobs Field | 29,124 | 36–37 | W1 |
| 74 | June 27 | Rockies | 5–3 | Miller (2–0) | Jennings (6–7) | Jiménez (8) | Jacobs Field | 27,252 | 37–37 | W2 |
| 75 | June 29 | | @ Tigers | 7–9 (11) | Dingman (2–1) | Jiménez (1–7) | — | | 30,457 | 37–38 | L1 |
| 76 | June 30 | | @ Tigers | 5–12 | Robertson (7–3) | Davis (2–6) | — | | 27,665 | 37–39 | L2 |
|
July: 16–12 (Home: 9–7; Away: 7–5)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 77 | July 1 | | @ Tigers | 7–6 (10) | Riske (4–2) | Urbina (3–3) | White (1) | | 25,159 | 38–39 | W1 |
| 78 | July 2 | | @ Reds | 15–2 | Tadano (1–0) | Sanchez (0–1) | — | | 36,156 | 39–39 | W2 |
| 79 | July 3 | | @ Reds | 2–4 | Wilson (8–2) | Elarton (0–7) | Graves (31) | | 38,708 | 39–40 | L1 |
| 80 | July 4 | | @ Reds | 4–5 (11) | Jones (6–2) | White (3–3) | — | | 30,375 | 39–41 | L2 |
| 81 | July 5 | | Rangers | 5–8 | Rogers (12–2) | Sabathia (5–4) | Cordero (25) | | 25,363 | 39–42 | L3 |
| 82 | July 6 | | Rangers | 4–1 | Lee (8–1) | Bierbrodt (1–1) | Riske (3) | | 16,796 | 40–42 | W1 |
| 83 | July 7 | | Rangers | 8–9 | Mahay (2–0) | Robertson (1–1) | Cordero (26) | | 18,499 | 40–43 | L1 |
| 84 | July 8 | | Rangers | 9–10 | Rodriguez (2–0) | Elarton (0–8) | — | | 24,914 | 40–44 | L2 |
| 85 | July 9 | | Athletics | 5–4 | Howry (1–0) | Dotel (1–5) | — | | 24,325 | 41–44 | W1 |
| 86 | July 10 | | Athletics | 7–15 | Mulder (12–2) | White (3–4) | — | | 28,448 | 41–45 | L1 |
| 87 | July 11 | | Athletics | 4–1 | Lee (9–1) | Zito (4–7) | Riske (4) | | 24,622 | 42–45 | W1 |
| ASG | | 8:46 p.m. EDT | 75th All-Star Game in Houston, TX | 9 – 4 NL | — | — | — | 2:59 | 41,886 | — | ASG |
| 88 | July 15 | | @ Mariners | 1–2 | Pineiro (5–10) | Westbrook (6–5) | Guardado (16) | | 32,896 | 42–46 | L1 |
| 89 | July 16 | | @ Mariners | 18–6 | Lee (10–1) | Blackley (1–2) | — | | 32,578 | 43–46 | W1 |
| 90 | July 17 | | @ Mariners | 6–5 | Sabathia (6–4) | Franklin (3–8) | Riske (5) | | 36,154 | 44–46 | W2 |
| 91 | July 18 | | @ Mariners | 5–7 | Hasegawa (3–3) | Miller (2–1) | Guardado (17) | | 37,363 | 44–47 | L1 |
| 92 | July 19 | | @ Angels | 8–5 (10) | Riske (5–2) | Percival (2–2) | Miller (1) | | 42,986 | 45–47 | W1 |
| 93 | July 20 | | @ Angels | 14–5 | Westbrook (7–5) | Washburn (10–5) | — | | 40,000 | 46–47 | W2 |
| 94 | July 21 | | White Sox | 0–14 | Buehrle (10–3) | Lee (10–2) | — | | 21,922 | 46–48 | L1 |
| 95 | July 22 | | White Sox | 0–3 | Garcia (8–8) | Sabathia (6–5) | Takatsu (7) | | 23,168 | 46–49 | L2 |
| 96 | July 23 | | Royals | 3–2 (11) | White (4–4) | Field (2–2) | — | | 26,504 | 47–49 | W1 |
| 97 | July 24 (1) | | Royals | 10–2 | Durbin (4–4) | George (1–2) | — | | 18,873 | 48–49 | W2 |
| 98 | July 24 (2) | | Royals | 4–3 | Miller (3–1) | Sullivan (3–3) | — | | 27,865 | 49–49 | W3 |
| 99 | July 25 | | Royals | 5–1 | Westbrook (8–5) | Greinke (2–8) | — | | 23,540 | 50–49 | W4 |
| 100 | July 26 | | Tigers | 4–13 | Maroth (8–7) | Lee (10–3) | — | | 18,359 | 50–50 | L1 |
| 101 | July 27 | | Tigers | 10–6 | Sabathia (7–5) | Knotts (5–6) | — | | 19,090 | 51–50 | W1 |
| 102 | July 28 | | Tigers | 5–4 | Elarton (1–8) | Walker (1–4) | Wickman (1) | | 23,213 | 52–50 | W2 |
| 103 | July 30 | | @ Royals | 7–6 (11) | Betancourt (4–4) | Sullivan (3–4) | — | | 32,079 | 53–50 | W3 |
| 104 | July 31 | | @ Royals | 3–10 | Greinke (3–8) | Tadano (1–1) | — | | 27,689 | 53–51 | L1 |
|
August: 14–15 (Home: 8–5; Away: 6–10)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 105 | August 1 | | @ Royals | 7–8 | May (8–11) | Sabathia (7–6) | Camp (2) | | 15,641 | 53–52 | L2 |
| 106 | August 2 | | @ Blue Jays | 1–6 | Lilly (8–7) | Lee (10–4) | — | | 17,549 | 53–53 | L3 |
| 107 | August 3 | | @ Blue Jays | 6–7 | Speier (3–6) | Betancourt (4–5) | Frasor (14) | | 15,025 | 53–54 | L4 |
| 108 | August 4 | | @ Blue Jays | 14–5 | Westbrook (9–5) | Towers (6–4) | — | | 15,675 | 54–54 | W1 |
| 109 | August 5 | | @ Blue Jays | 6–3 (10) | Betancourt (5–5) | Ligtenberg (1–4) | Wickman (2) | | 30,037 | 55–54 | W2 |
| 110 | August 6 | | @ White Sox | 3–2 | Sabathia (8–6) | Buehrle (10–5) | Wickman (3) | | 23,811 | 56–54 | W3 |
| 111 | August 7 | | @ White Sox | 6–5 | Miller (4–1) | Takatsu (4–3) | Wickman (4) | | 32,790 | 57–54 | W4 |
| 112 | August 8 | | @ White Sox | 2–3 | Takatsu (5–3) | Betancourt (5–6) | — | | 25,897 | 57–55 | L1 |
| 113 | August 9 | | @ White Sox | 13–11 | Westbrook (10–5) | Diaz (1–3) | — | | 31,116 | 58–55 | W1 |
| 114 | August 10 | | Blue Jays | 2–0 | Durbin (5–4) | Bush (1–3) | Wickman (5) | | 19,942 | 59–55 | W2 |
| 115 | August 11 | | Blue Jays | 3–2 | Sabathia (9–6) | Frederick (0–1) | Wickman (6) | | 23,696 | 60–55 | W3 |
| 116 | August 12 | | Blue Jays | 6–2 | Riske (6–2) | Ligtenberg (1–5) | — | | 22,734 | 61–55 | W4 |
| 117 | August 13 | | Twins | 8–2 | Elarton (2–8) | Silva (10–8) | — | | 30,101 | 62–55 | W5 |
| 118 | August 14 | | Twins | 7–1 | Westbrook (11–5) | Lohse (5–10) | — | | 40,942 | 63–55 | W6 |
| 119 | August 15 | | Twins | 2–4 (10) | Rincon (10–5) | White (4–5) | Nathan (34) | | 38,019 | 63–56 | L1 |
| 120 | August 16 | | @ Rangers | 2–5 | Ramirez (4–3) | Sabathia (9–7) | Cordero (36) | | 23,551 | 63–57 | L2 |
| 121 | August 17 | | @ Rangers | 4–16 | Erickson (1–3) | Lee (10–5) | Brocail (1) | | 24,864 | 63–58 | L3 |
| 122 | August 18 | | @ Rangers | 2–5 | Rogers (15–5) | Elarton (2–9) | Cordero (37) | | 31,572 | 63–59 | L4 |
| 123 | August 20 | | @ Twins | 1–5 | Lohse (6–10) | Westbrook (11–6) | — | | 25,157 | 63–60 | L5 |
| 124 | August 21 | | @ Twins | 1–8 | Mulholland (4–6) | Durbin (5–5) | — | | 27,945 | 63–61 | L6 |
| 125 | August 22 | | @ Twins | 3–7 | Radke (9–6) | Sabathia (9–8) | — | | 28,587 | 63–62 | L7 |
| 126 | August 23 | | Yankees | 4–6 | Gordon (5–3) | Wickman (0–1) | Rivera (42) | | 33,172 | 63–63 | L8 |
| 127 | August 24 | | Yankees | 4–5 | Gordon (6–3) | Wickman (0–2) | Rivera (43) | | 31,729 | 63–64 | L9 |
| 128 | August 25 | | Yankees | 4–3 | Riske (7–2) | Gordon (6–4) | Betancourt (3) | | 30,605 | 64–64 | W1 |
| 129 | August 26 | | White Sox | 9–14 | Cotts (2–3) | Durbin (5–6) | — | | 30,049 | 64–65 | L1 |
| 130 | August 27 | | White Sox | 6–3 | Sabathia (10–8) | Grilli (0–1) | Wickman (7) | | 30,527 | 65–65 | W1 |
| 131 | August 28 | | White Sox | 3–5 | Contreras (12–6) | Lee (10–6) | Takatsu (13) | | 37,374 | 65–66 | L1 |
| 132 | August 29 | | White Sox | 9–0 | Elarton (3–9) | Garland (9–10) | — | | 32,834 | 66–66 | W1 |
| 133 | August 31 | | @ Yankees | 22–0 | Westbrook (12–6) | Vazquez (13–8) | — | | 51,777 | 67–66 | W2 |
|
September: 12–14 (Home: 4–9; Away: 8–5)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 134 | September 1 | | @ Yankees | 3–5 | Hernandez (6–0) | Sabathia (10–9) | Rivera (46) | | 41,448 | 67–67 | L1 |
| 135 | September 2 | | @ Yankees | 1–9 | Lieber (10–8) | Lee (10–7) | — | | 37,963 | 67–68 | L2 |
| 136 | September 3 | | Angels | 5–10 | Escobar (9–9) | Elarton (3–10) | — | | 20,994 | 67–69 | L3 |
| 137 | September 4 | | Angels | 1–6 | Washburn (11–5) | Davis (2–7) | — | | 23,786 | 67–70 | L4 |
| 138 | September 5 | | Angels | 1–2 | Lackey (12–11) | Westbrook (12–7) | Rodríguez (11) | | 26,208 | 67–71 | L5 |
| 139 | September 6 | | @ Mariners | 6–0 | Sabathia (11–9) | Meche (4–6) | — | | 33,084 | 68–71 | W1 |
| 140 | September 8 | | @ Mariners | 9–5 | Lee (11–7) | Baek (1–2) | — | | 28,764 | 69–71 | W2 |
| 141 | September 10 | | @ Athletics | 4–3 (12) | White (5–5) | Duchscherer (5–6) | Wickman (8) | | 24,154 | 70–71 | W3 |
| 142 | September 11 | | @ Athletics | 4–5 | Rincon (1–0) | Howry (1–1) | Dotel (33) | | 30,436 | 70–72 | L1 |
| 143 | September 12 | | @ Athletics | 0–1 | Zito (11–10) | Westbrook (12–8) | Dotel (34) | | 29,107 | 70–73 | L2 |
| 144 | September 14 | | Tigers | 3–11 | Bonderman (10–11) | Denney (0–1) | — | | 16,489 | 70–74 | L3 |
| 145 | September 15 | | Tigers | 5–3 | Howry (2–1) | Yan (2–4) | Wickman (9) | | 15,411 | 71–74 | W1 |
| 146 | September 16 | | Tigers | 4–6 | Walker (3–4) | Sabathia (11–10) | Yan (4) | | 15,943 | 71–75 | L1 |
| 147 | September 17 | | Royals | 4–6 | Wood (3–7) | Westbrook (12–9) | Affeldt (11) | | 14,347 | 71–76 | L2 |
| 148 | September 18 | | Royals | 1–7 | Gobble (8–8) | Lee (11–8) | — | | 17,848 | 72–76 | L3 |
| 149 | September 19 | | Royals | 8–3 | Denney (1–1) | Bautista (0–3) | — | | 16,745 | 72–77 | W1 |
| 150 | September 20 | | @ Tigers | 1–3 | Maroth (11–11) | Elarton (3–11) | Yan (5) | | 13,820 | 72–78 | L1 |
| 151 | September 21 | | @ Tigers | 8–7 | Howry (3–1) | Yan (3–5) | Wickman (10) | | 11,351 | 73–78 | W1 |
| 152 | September 22 | | @ Tigers | 7–6 | Westbrook (13–9) | Ledezma (4–3) | — | | 16,360 | 74–78 | W2 |
| 153 | September 23 | | Twins | 9–7 | Lee (12–8) | Durbin (0–1) | Betancourt (4) | | 18,053 | 75–78 | W3 |
| 154 | September 24 | | Twins | 2–8 | Santana (20–6) | Denney (1–2) | — | | 16,253 | 75–79 | L1 |
| 155 | September 25 | | Twins | 5–3 | Howry (4–1) | Romero (7–3) | Wickman (11) | | 23,541 | 76–79 | W1 |
| 156 | September 26 | | Twins | 2–6 | Silva (14–8) | Cruceta (0–1) | — | | 22,091 | 76–80 | L1 |
| 157 | September 27 | | @ Royals | 6–1 | Westbrook (14–9) | Cerda (1–3) | — | | 11,544 | 77–80 | W1 |
| 156 | September 28 | | @ Royals | 5–1 | Lee (13–8) | May (9–19) | — | | 11,847 | 78–80 | W2 |
| 159 | September 29 | | @ Royals | 5–2 | Bartosh (1–0) | Wood (3–8) | Wickman (12) | | 11,193 | 79–80 | W3 |
|
October: 1–2 (Home: 0–0; Away: 1–2)
|
Legend: = Win = Loss = Eliminated from playoff race = Postponement Bold = Indians team member |