2015 Columbus Challenger

Country	Player	Rank1	Seed
USA	Tim Smyczek	107	1
AUS	John-Patrick Smith	111	2
USA	Bjorn Fratangelo	118	3
USA	Ryan Harrison	129	4
USA	Austin Krajicek	130	5
SLO	Blaž Rola	139	6
GBR	Brydan Klein	178	7
USA	Dennis Novikov	208	8

• ¹ Rankings are as of September 14, 2015.^[1]

No Wild Cards were distributed for this event.

The following players received entry into the singles main draw courtesy of a protected ranking:

• Dennis Nevolo
• Peter Polansky

The following players received entry from the qualifying draw:

• Hugo Di Feo
• Damon Gooch
• Peter Kobelt
• Dean O'Brien

• Dennis Novikov def. Ryan Harrison, 6–3, 3–6, 6–3

• Chase Buchanan / Blaž Rola def. Mitchell Krueger / Eric Quigley, 6–4, 4–6, [19–17]