| Index to colors and formatting |
| Big South member won |
| Big South member lost |
| Big South teams in bold |
All times Eastern time (UTC-4 before November 5, UTC-5 from November 5 forward).
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Aug. 31 | 6:30 PM | Presbyterian | Wake Forest | BB&T Field • Winston-Salem, NC | L 7–51 | 22,643 | [2] |
| Aug. 31 | 7:00 PM | Kennesaw State | Samford | Seibert Stadium • Homewood, AL | L 23–28 | 4,908 | [3] |
| Sep. 2 | 3:00 PM | Lafayette | Monmouth | Kessler Field • West Long Branch, NJ | W 31–12 | 3,898 | [4] |
| Sep. 2 | 4:00 PM | Charleston Southern | Mississippi State | Davis Wade Stadium • Starkville, MS | L 0–49 | 54,215 | [5] |
| Sep. 2 | 6:00 PM | North Carolina A&T | Gardner–Webb | Ernest W. Spangler Stadium • Boiling Springs, NC | L 3–45 | 7,015 | [6] |
| Sep. 2 | 7:00 PM | Liberty | Baylor | McLane Stadium • Waco, TX | W 48–45 | 45,784 | [7] |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Sep. 9 | 12:00 PM[a] | The Citadel | Presbyterian | Bailey Memorial Stadium • Clinton, SC[a] | L 7–48 | 2,586 | [8] |
| Sep. 9 | 1:00 PM | Lehigh | Monmouth | Kessler Field • West Long Branch, NJ | W 46–27 | 2,839 | [9] |
| Sep. 9 | 4:00 PM | Gardner–Webb | Wyoming | War Memorial Stadium • Laramie, WY | L 0–27 | 19,051 | [10] |
| Sep. 9 | 6:00 PM | Charleston Southern | South Carolina State | Oliver C. Dawson Stadium • Orangeburg, SC | Postponed [b] | | — |
| Sep. 9 | 6:00 PM | Morehead State | Liberty | Williams Stadium • Lynchburg, VA | W 58–17 | 17,118 | [11] |
| Sep. 9 | 7:00 PM | Tennessee Tech | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | W 27–14 | 8,418 | [12] |
- 1 2 The game between Presbyterian and The Citadel was originally scheduled to take place at The Citadel, at 6:00 PM, but was rescheduled in advance of the arrival of Hurricane Irma.
- ↑ The game between South Carolina State and Charleston Southern was postponed in advance of the arrival of Hurricane Irma.
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Sep. 16 | 6:00 PM | Charleston Southern | Elon | Rhodes Stadium • Elon, NC | L 17–19 | 5,248 | [13] |
| Sep. 16 | 6:00 PM | Western Carolina | Gardner–Webb | Ernest W. Spangler Stadium • Boiling Springs, NC | L 27–42 | 6,152 | [14] |
| Sep. 16 | 6:00 PM | Indiana State | Liberty | Williams Stadium • Lynchburg, VA | W 42–41 | 16,060 | [15] |
| Sep. 16 | 7:00 PM | Monmouth | Albany | Bob Ford Field • Albany, NY | L 14–28 | 6,384 | [16] |
| Sep. 16 | 7:00 PM | Campbell | Presbyterian | Bailey Memorial Stadium • Clinton, SC | W 28–16 | 2,204 | [17] |
| Sep. 16 | 8:00 PM | Kennesaw State | Alabama State | New ASU Stadium • Montgomery, AL | W 20–14 | 11,000 | [18] |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Sep. 23 | 1:30 PM | Gardner–Webb | Wofford | Gibbs Stadium • Spartanburg, SC | L 24–27 | 7,211 | [19] |
| Sep. 23 | 2:00 PM | Monmouth | Hampton | Armstrong Stadium • Hampton, VA | W 30–23 OT | 5,123 | [20] |
| Sep. 23 | 6:00 PM | Point | Charleston Southern | Buccaneer Field • North Charleston, SC | W 66–0 | 1,945 | [21] |
| Sep. 23 | 7:00 PM | Liberty | Jacksonville State | JSU Stadium • Jacksonville, AL | L 10–31 | 23,944 | [22] |
| Sep. 23 | 7:00 PM | Cumberland | Presbyterian | Bailey Memorial Stadium • Clinton, SC | W 27–20 | 2,140 | [23] |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Sep. 30 | 3:30 PM | North Greenville | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | W 38–34 | 6,161 | [24] |
| Sep. 30 | 6:00 PM | Mississippi Valley State | Charleston Southern | Buccaneer Field • North Charleston, SC | W 58–7 | 1,456 | [25] |
| Sep. 30 | 6:00 PM | Saint Francis | Liberty | Williams Stadium • Lynchburg, VA | L 7–13 | 15,886 | [26] |
| Sep. 30 | 6:00 PM | Monmouth | Bucknell | Christy Mathewson–Memorial Stadium • Lewisburg, PA | W 35–13 | 1,942 | [27] |
| Sep. 30 | 7:00 PM | Wofford | Presbyterian | Bailey Memorial Stadium • Clinton, SC | L 7–31 | 2,862 | [28] |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Oct. 7 | 1:05 PM | Monmouth | Holy Cross | Fitton Field • Worcester, MA | | | — |
| Oct. 7 | 1:30 PM | Shorter | Gardner–Webb | Ernest W. Spangler Stadium • Boiling Springs, NC | | | — |
| Oct. 7 | 2:00 PM | Saint Francis | Presbyterian | Bailey Memorial Stadium • Clinton, SC | | | — |
| Oct. 7 | 7:00 PM | Texas Southern | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Oct. 14 | 12:00 PM | Charleston Southern | Presbyterian | Bailey Memorial Stadium • Clinton, SC | | | — |
| Oct. 14 | 2:00 PM | Gardner–Webb | North Carolina Central | O'Kelly–Riddick Stadium • Durham, NC | | | — |
| Oct. 14 | 6:00 PM | Kennesaw State | Liberty | Williams Stadium • Lynchburg, VA | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Oct. 21 | 1:00 PM | Liberty | Monmouth | Kessler Field • West Long Branch, NJ | | | — |
| Oct. 21 | 6:00 PM | Savannah State | Charleston Southern | Buccaneer Field • North Charleston, SC | | | — |
| Oct. 21 | 7:00 PM | Gardner–Webb | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Oct. 28 | 12:00 PM | Liberty | Gardner–Webb | Ernest W. Spangler Stadium • Boiling Springs, NC | | | — |
| Oct. 28 | 2:00 PM | Kennesaw State | Presbyterian | Bailey Memorial Stadium • Clinton, SC | | | — |
| Oct. 28 | 6:00 PM | Monmouth | Charleston Southern | Buccaneer Field • North Charleston, SC | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Nov. 4 | 1:00 PM | Presbyterian | Monmouth | Kessler Field • West Long Branch, NJ | | | — |
| Nov. 4 | 1:30 PM | Charleston Southern | Gardner–Webb | Ernest W. Spangler Stadium • Boiling Springs, NC | | | — |
| Nov. 4 | 2:00 PM | Kennesaw State | Montana State | Bobcat Stadium • Bozeman, MT | | | — |
| Nov. 4 | 3:30 PM | Duquesne | Liberty | Williams Stadium • Lynchburg, VA | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Nov. 11 | 12:00 PM | Gardner–Webb | Monmouth | Kessler Field • West Long Branch, NJ | | | — |
| Nov. 11 | 3:30 PM | Charleston Southern | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | | | — |
| Nov. 11 | 3:30 PM | Presbyterian | Liberty | Williams Stadium • Lynchburg, VA | | | — |
| Date | Time | Visiting team | Home team | Site | Result | Attendance | Reference |
| Nov. 18 | TBA | Monmouth | Kennesaw State | Fifth Third Bank Stadium • Kennesaw, GA | | | — |
| Nov. 18 | 12:00 PM | Liberty | Charleston Southern | Buccaneer Field • North Charleston, SC | | | — |
| Nov. 18 | 1:00 PM | Gardner–Webb | Presbyterian | Bailey Memorial Stadium • Clinton, SC | | | — |