2021 American Athletic Conference Football Championship Game

Taking the opening kickoff, the Cougars marched right down the field mixing runs and passes to get into Cincinnati territory. The Bearcats defense stiffened and forced the Cougars to settle for a 37-yard field goal by Dalton Witherspoon to take an early 3–0 lead. The Bearcats responded with a crisp 5-play, 82-yard drive with QB Desmond Ridder completing passes to four different receivers. Ridder found WR Tyler Scott on a 25-yard post pattern pass in the end zone to give the Bearcats a 7–3 lead. The Cougars responded with a solid touchdown drive of their own, going 74 yards in 10 plays, capped by a QB Clayton Tune pass to WR Tank Dell. That lead was short lived as on the Bearcat first play from scrimmage following the kickoff Jerome Ford took the handoff, slipped through the right side and dashed untouched 79 yards for a touchdown. It was Ford's 4th touchdown run of 75 yards or more of the season. The Bearcats were back in front 14–10 and the sellout crowd of 37,978 buckled in for what was shaping up to be a high scoring shootout. The Cougars strung together another time-consuming drive but once again the Bearcats defense stopped Houston inside the 30. Witherspoon connected on a 46-yard field goal to narrow the Cincinnati lead to 14–13. The Bearcats could not extend their lead after a fine kickoff return by Tre Tucker set the Bearcats up in Houston territory. The Bearcats got inside the 10 but the drive stalled and Christian Lowery missed a 23-yard field goal. The Bearcats took a 14–13 lead into halftime.

Taking the second half kickoff, the Bearcats went 75 yards on 6 plays, highlighted by a 44-yard pass from Ridder to WR Alec Pierce who made a spectacular diving catch on a seemingly overthrown ball. The Bearcats took advantage of a 4th down pass interference call on Houston and scored on an 8-yard swing pass from Ridder to TE Leonard Taylor. With the score now 21–13, the Cougars next drive ended after one play as LB Joel Dublanko intercepted a Tune pass and returned it to the Houston 23 yard line. Two plays later, Pierce out jumped Houston CB Marcus Jones in the end zone and the Bearcats now held a 28–13 lead less than 5 minutes into the 2nd half. The Cougars went three-and-out on their next series and punted. Three plays later, Ford broke over the left side finding a wide-open seam and sprinted 42 yards for a touchdown, the third of the 3rd quarter in less than 8 minutes of game time. The 3rd quarter continued to be a struggle for the Cougars as the Bearcats defense continued to stifle them at every turn. The Cougars were held to −6 yards offense in the 3rd quarter, gaining one first down, and no points. The Cougars did manage to score a touchdown midway through the 4th quarter to close the gap to 35–20, but that would be as close as they would get. At game's end, much of the sellout crowd stormed the field in celebration as the Bearcats clinched their second straight American Athletic Football Championship with the win. Jerome Ford was named the Most Outstanding Player with 187 rushing yards and two touchdowns. Desmond Ridder only completed 11 passes on 17 attempts for 190 yards. His passes were judicious and sparingly needed as the Bearcat running game rang up 210 yards. The Bearcat defense registered 8 sacks, with Joel Dublanko notching a pair to go along with 7 tackles and the games lone turnover on the 3rd quarter interception. The Bearcats won despite only having the ball 19 minutes on offense. The Bearcats ended the evening as the nation's only unbeaten team in the 2021 season and with the final results of the College Football Playoff poll the next day would be chosen as one of the four teams that would play for the national championship.

• Game statistics at statbroadcast.com