2021 Courmayeur Ladies Open

• Donna Vekić def. Clara Tauson 7–6^(7–3), 6–2

This was Vekić's third WTA singles title, and first since 2017.

• Wang Xinyu / Zheng Saisai def. Eri Hozumi / Zhang Shuai 6–4, 3–6, [10–5]

Country	Player	Rank1	Seed
TUN	Ons Jabeur	8	1
ITA	Camila Giorgi	36	2
RUS	Liudmila Samsonova	42	3
CRO	Petra Martić	47	4
DEN	Clara Tauson	48	5
USA	Alison Riske	49	6
ITA	Jasmine Paolini	54	7
CHN	Zhang Shuai	55	8
USA	Ann Li	60	9
UKR	Dayana Yastremska	76	10

• Rankings are as of October 18, 2021.^[3][4]

The following players received wildcards into the main draw:

• Martina Caregaro
• Jessica Pieri
• Lucrezia Stefanini

The following players received entry using a protected ranking into the main draw:

• Vitalia Diatchenko
• Kateryna Kozlova
• Mandy Minella

The following players received entry from the qualifying draw:

• Aliona Bolsova
• Cristina Bucșa
• Martina Di Giuseppe
• Giulia Gatto-Monticone
• Stephanie Wagner
• Zheng Qinwen

The following players received entry as lucky losers:

• Urszula Radwańska
• Ankita Raina

Before the tournament

• Belinda Bencic → replaced by Kamilla Rakhimova
• Danielle Collins → replaced by Anna Kalinskaya
• Camila Giorgi → replaced by Urszula Radwańska
• Ons Jabeur → replaced by Ankita Raina
• Tereza Martincová → replaced by Mandy Minella
• Greet Minnen → replaced by Hsieh Su-wei
• Nuria Párrizas Díaz → replaced by Donna Vekić
• Elena Rybakina → replaced by Kateryna Kozlova
• Maria Sakkari → replaced by Stefanie Vögele
• Kateřina Siniaková → replaced by Lucia Bronzetti
• Sara Sorribes Tormo → replaced by Magdalena Fręch