2022 Internazionali Femminili di Palermo

Irina-Camelia Begu defeated Lucia Bronzetti 6–2, 6–2

• It was Begu's only singles title of the year and the fifth of her career.

• Anna Bondár / Kimberley Zimmermann defeated Amina Anshba / Panna Udvardy 6–3, 6–2.

Country	Player	Rank1	Seed
ITA	Martina Trevisan[2]	26	1
KAZ	Yulia Putintseva	32	2
CHN	Zhang Shuai	37	3
ESP	Sara Sorribes Tormo	43	4
FRA	Caroline Garcia	48	5
ROU	Irina-Camelia Begu	49	6
HUN	Anna Bondár	53	7
ESP	Nuria Párrizas Díaz	54	8

• ^† Rankings are as of 11 July 2022 ^[3]

The following players received wildcards into the main draw:

• Elisabetta Cocciaretto
• Sara Errani
• Lucrezia Stefanini

The following player received entry using a protected ranking:

• Laura Siegemund

The following players received entry from the qualifying draw:

• Elina Avanesyan
• Marina Bassols Ribera
• Léolia Jeanjean
• Rebeka Masarova
• Asia Muhammad
• Matilde Paoletti

The following player received entry as a lucky loser:

• Carolina Alves
• Jaimee Fourlis
• Julia Grabher

Before the tournament

• Kaja Juvan → replaced by Panna Udvardy
• Danka Kovinić → replaced by Ylena In-Albon
• Petra Martić → replaced by Jaimee Fourlis
• Arantxa Rus → replaced by Ana Bogdan
• Laura Siegemund → replaced by Julia Grabher
• Ajla Tomljanović → replaced by Chloé Paquet
• Martina Trevisan → replaced by Carolina Alves

During the tournament

• Zhang Shuai